Carnegie Mellon University

Gross Mucosal Pathology

During each day in quarantine, participants received an ear, nose, and throat (ENT) exam from a study clinician.


In the British Cold Study, 6 indicators of gross mucosal pathology were rated by study clinicians:

  • Nasal obstruction
  • Nasal discharge
  • Mucopurulent discharge
  • Post-nasal discharge
  • Cervical adenitis
  • Hoarseness, cough, sputum

Each clinical indicator was rated as being absent, slight, moderate, or severe (See Clinician Daily Observations).


In all 3 Pittsburgh Cold Studies and the Pittsburgh Mind-Body Center Study, clinicians rated participants on the 7 specific ENT signs listed in Table 1, and scored them as indicated based on physical examination.

Gross Mucosal Pathology


Alper, C. M., Doyle, W. J., Skoner, D. P., Buchman, C. A., Cohen, S., & Gwaltney, J. M. (1998).  Pre-challenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain hanksClinical Infectious Diseases, 27, 119-128.