Gross Mucosal Pathology
During each day in quarantine, participants received an ear, nose, and throat (ENT) exam from a study clinician.
In the British Cold Study, 6 indicators of gross mucosal pathology were rated by study clinicians:
- Nasal obstruction
- Nasal discharge
- Mucopurulent discharge
- Post-nasal discharge
- Cervical adenitis
- Hoarseness, cough, sputum
Each clinical indicator was rated as being absent, slight, moderate, or severe (See Clinician Daily Observations).
PCS1, PCS2, PMBC, PCS3
In all 3 Pittsburgh Cold Studies and the Pittsburgh Mind-Body Center Study, clinicians rated participants on the 7 specific ENT signs listed in Table 1, and scored them as indicated based on physical examination.
Alper, C. M., Doyle, W. J., Skoner, D. P., Buchman, C. A., Cohen, S., & Gwaltney, J. M. (1998). Pre-challenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain hanks. Clinical Infectious Diseases, 27, 119-128.