Neuroscience Research Lab - student pointing to brain scans on monitor, MRI in the background

Areas of Research at Mellon College of Science

Powerful cross-disciplinary teams focus on emerging areas with the potential for world-changing breakthroughs for profound public benefit. Our faculty experts and thought leaders are not only contributing to the future — they are building it, with unrivaled insight and impact.

Breakthroughs That Matter

Carnegie Mellon University research is redefining scientific disciplines and making the kinds of discoveries that change how we live, connect and protect the world around us. And at every level — undergraduate, graduate and doctoral — students have powerful learning opportunities, working alongside leading scientists to shape the future through research that matters. Learn about the exciting work the Mellon College of Science faculty and staff are doing on the frontiers of advanced science.
 

Sustainability Science

CMU research scientists are developing smart solutions for urgent sustainability issues. Their work advances our understanding of changes in the environment and builds cleaner technologies that safeguard life on Earth.

Stefan Bernhard - man standing in front of Mellon Institute wearing a dark blue button shirt

Stefan Bernhard

Focus areas: Research in luminescent materials, solar fuels, organic photovoltaics, organic light-emitting devices, circular polarized luminescence

Terrence Collins - older man with white hair sitting in front of bookshelf wearing a olive green jacket over a dark blue polo

Terrence Collins

Focus areas: Green chemistry, green oxidation catalysis in water, inorganic chemistry, biomimetic chemistry of peroxidase enzymes, mechanisms of oxidation catalysis, novel approaches to water purification

Neil Donahue - smiling man with red hair and full beard, wearing a terracotta button shirt

Neil Donahue

Focus areas: Atmospheric chemistry, organic aerosol, kinetics, reaction dynamics, radical-molecule reactivity, ozonolysis, mass spectrometry

Hyung Kim - smiling man with dark hair and glasses wearing a navy suit coat and button shirt

Hyung Kim

Focus areas: Theoretical and computational chemistry, equilibrium and nonequilibrium statistical mechanics, computer simulations, chemical reactions and spectroscopy in solution, green solvents, supercapacitors, multi-domain proteins

Ryan Sullivan - man in glasses with brown hair, beard and mustache, wearing a gray shortsleeve, standing with arms crossed

Ryan Sullivan

Focus areas: Atmospheric chemistry, aerosol instrumentation, single-particle analysis, mass spectrometry, laser spectroscopy, heterogeneous chemistry, combustion, particle hygroscopicity, cloud nucleation, aerosol-cloud-climate interactions

Computational Finance

Our faculty advance the math behind modern finance to model market uncertainty and optimize decisions with AI engineering. Their leading-edge work builds more resilient systems that help industries manage risk and plan for the future.

Dmitry Kramkov - man with short gray hair and glasses wearing a blue striped button-down shirt

Dmitry Kramkov

Focus areas: Mathematical Finance and Theory of Stochastic Processes with equilibrium-based models

Martin Larsson - man with red beard and mustache wearing a light-colored button shirt

Martin Larsson

Focus areas: Mathematical Finance and related topics in stochastic analysis and probability

Cosmology

MCS researchers are solving the complex puzzles of the Universe — investigating dark matter, building novel telescopes and studying particles from the Big Bang to deepen our understanding of space, time and the fundamental forces that govern them.

John Alison - headshot of a smiling man with short curly dark hair

John Alison

Focus areas: Theory of fundamental particles and their interactions

Rupert Croft - man wearing glasses and a black collared shirt

Rupert Croft

Focus areas: Cosmology, the Big Bang, inflation, dark matter

Tiziana Di Matteo - smiling woman with dark brown hair loosely pulled back and wearing a scooped-necked gray and black blouse

Tiziana Di Matteo

Focus areas: Black holes, high-energy astrophysics, cosmology

Tina Kahniashvili - woman with light brown bangs and short length hair wearing a gray turtleneck and brown sweater

Tina Kahniashvili

Focus areas: High-quality cosmological data, observations of the cosmic microwave background, large-scale structure distribution, gravitational lensing and other observational data supporting a consistent "standard" model of the Universe

Rachel Mandelbaum - smiling woman with glasses and light green crewneck blouse and a tichel-style light green head scarf

Rachel Mandelbaum

Focus areas: Observational cosmology and galaxy studies, weak gravitational lensing and other analysis techniques

Diana Parno - headshot of smiling caucasian female with dark brown hair pulled back

Diana Parno

Focus areas: Physics of the neutrino, a fundamental particle that is generated in particle decays and nuclear reactions, which, in the Standard Model of particle physics, interacts only via the weak force

Manfred Paulini - man wearing glasses and a navy blazer and light blue shirt

Manfred Paulini

Focus areas: Particle physics and cosmology

Riccardo Penco - smiling man with dark rimmed glasses, beard and mustache

Riccardo Penco

Focus areas: Physical systems, cosmology, astrophysics, condensed matter

Jeffrey Peterson - man with pepper-colored hair and wearing a terracotta colored polo

Jeffrey Peterson

Focus areas: Designing and building novel radio telescopes to study dark energy

Ira Rothstein - headshot of a man with short dark wavy hair and brown eyes

Ira Rothstein

Focus areas: Elementary particle physics, gravity wave physics, astrophysics/cosmology and QCD

Hy Trac - man with dark side-parted hair and wearing a light blue shirt

Hy Trac

Focus areas: Computational and theoretical cosmology, astrophysics

Matthew Walker - man with brown hair wearing a white collared shirt

Matthew Walker

Focus areas: Astrophysical properties of dark matter

Life Sciences Breakthroughs

Breakthroughs in the life sciences at MCS are driving discoveries in cancer, neurodegeneration, genetic disorders and other diseases. Expert faculty are reprogramming cells, decoding genetic variations and applying chemistry and computation to transform medicine and biotechnology.

Dannie Durand - distinguished-looking woman with shoulder-length brown hair and glasses

Dannie Durand

Focus areas: Computational analysis of molecular sequence data in genetics

Charles Ettensohn - man with white hair and glasses wearing a navy collared shirt

Charles Ettensohn

Focus areas: Genetic encoding, early patterning, morphogenesis and development

Luisa Hiller - smiling woman with long red hair and wearing starfish necklace

N. Luisa Hiller

Focus areas: Applying bacterial infections, comparative genomics, bioinformatics and phylogenetics to banked bacterial isolates from clinical infections

Fred Lanni holds up a vial of biofilm in a lab and smiles at the camera.

Frederick Lanni

Focus areas: Mechanical activities of non-muscle cells drive many processes in embryonic development, tissue maintenance and healing, immune cell migration and function, neuronal circuit formation and progression of certain diseases

Tina Lee - woman smiling at camera with shoulder-length brown hair and dark rimmed glasses

Tina Lee

Focus areas: The structure and function relationship of the endoplasmic reticulum and how the structure of the organelle might be modified to respond to changes in cell physiology

Adam Linstedt - smiling man in glasses and brown hair wearing white crew neck shirt

Adam Linstedt

Focus areas: Molecular mechanisms that establish and maintain the membrane-bounded subcellular compartments of the secretory and endocytic pathways

Brooke McCartney - friendl smiling woman with shoulder length brown hair in a lavendar button shirt

Brooke McCartney

Focus areas: Cancer cell research, tumor suppression, gene mutation

C. Joel McManus - man with light brown hair and glasses, wearing light green collared shirt

Joel McManus

Focus areas: Variation in gene expression and how it contributes to phenotypic diversity and disease

Jonathan Minden - man with pepper-colored hair and goatee wearing rimless glasses and light colored button shirt

Jonathan Minden

Focus areas: Gene and cellular mutation and pattern formation in environmental changes and proteomics

Gordon Rule - man in a pinstriped blue button shirt and glasses

Gordon Rule

Focus areas: Inter-molecular interactions in biological systems, enzyme-substrate interactions, protein-lipid interactions, antibody-antigen interactions, RNA structure, protein-nucleic acid interactions

Russell Schwartz - man with dark hair and blue collared shirt looking off to the side

Russell Schwartz

Focus areas: Analysis of genetic variations, with specific application to inference of population subgroups and phylogenetics

John Woolford - older man with a gray mustache and glasses wearing a light green polo

John Woolford

Focus areas: Assembly of ribosomes in eukaryotes, identify and characterize proteins necessary for the biogenesis of ribosomes

Huaiying Zhang - asian woman with hair loosely pulled to the back wearing a floral blouse

Huaiying Zhang

Focus areas: Investigate functional significance of phase transition in cells, engineer synthetic organelles and control phase transition for cancer therapy

Yongxin (Leon) Zhao - distinguished man in lab coat and wearing dark rimmed glasses

Yongxin (Leon) Zhao

Focus areas: Mapping structural and molecular properties of complex biological systems

Subha Das - friendly-smiling man with dark hair and glasses wearing a gray collared sweater

Subha Das

Focus areas: Organic synthesis, nucleic acids chemistry, RNA biochemistry, RNA-protein recognition, nanotechnology

Yisong (Alex) Guo - Asian male wearing a white collared button shirt

Yisong (Alex) Guo

Focus areas: Spectroscopy, bioinorganic chemistry, Mössbauer and EPR spectroscopy, synchrotron radiation techniques, nuclear resonance vibrational spectroscopy (NRVS), synchrotron Mössbauer, metalloproteins, enzyme mechanisms, transition metal complexes, electronic structures, density functional theory

Michael Hendrich - male with blond wavy hair wearing a gray-mint plaid shirt

Michael Hendrich

Focus areas: Spectroscopy, biophysical chemistry, enzymatic mechanisms, bioinorganic chemistry, metalloenzymes

Anna Kietrys - smiling woman in a brown sweater and white shirt with dark haired pulled back

Anna Kietrys

Focus areas: Chemical biology, RNA structure and function, epitranscriptomics, RNA signaling, aging and neurodegeneration

Maria Kurnikova - light brown haired woman in a printed blazer and orange crew neck

Maria Kurnikova

Focus areas: Theory, computational chemistry, biophysical, molecular modeling, continuum electrostatics, drift-diffusion models, ion channels, membrane receptors, signal transduction, membrane protein structure-function relations, flexibility and rigidity in protein dynamics

Danith Ly - dark haired man in a blue collared shirt and glasses

Danith Ly

Focus areas: Bioorganic chemistry, chemical biology, gene regulation, cellular delivery, protein engineering, molecular self-assembly

Markus Deserno sits in front of a bookshelf in his office and smiles at the camera.

Markus Deserno

Focus areas: Theoretical and computational techniques regarding lipid membranes, proteins, viruses or DNA

Frank Heinrich - friendly-smiling man with glasses and brown wavy hair

Frank Heinrich

Focus areas: Disease-relevant proteins, peptides and small molecules at interfaces and, in particular, interacting with lipid membranes

Quantum Information

Quantum science research at MCS explores particle behavior, new materials and the mysterious rules that govern matter at the smallest scales. Our expert faculty in quantum materials and particle physics are laying the groundwork for breakthroughs in computing, energy and next-generation technologies.

Roy Briere - man with a dark, trimmed beard and mustach wearing round silver glasses

Roy Briere

Focus areas: High-energy particle physics, the study of the decays and other properties of the different types of quarks

Randall Feenstra - man with light brown hair and glasses wearing a brown gingham button shirt

Randall Feenstra

Focus areas: Structural and electronic properties of semiconductor materials and devices

Benjamin Hunt - clean-shaven dark haired man in a maroon button shirt

Benjamin Hunt

Focus areas: Condensed-matter physics, electrons’ behavior under extreme conditions in ultra-low temperatures and high magnetic fields

Jyoti Katoch - long dark-haired woman smiling at camera

Jyoti Katoch

Focus areas: Electronic, optical and spin-dependent properties of novel quantum materials like two-dimensional materials and their devices

Curtis Meyer - distinguished older man in glasses and suit with a bowtie

Curtis Meyer

Focus areas: Protons and neutrons, quarks and gluons, quantum chromodynamics

Colin Morningstar - man in business attire wearing round-framed glasses

Colin Morningstar

Focus areas: Nonperturbative phenomena in quantum field theories, with particular emphasis on the study of hadron formation and confinement in quantum chromodynamics, using computer simulations of quarks and gluons

Jeffrey Peterson - man with pepper-colored hair and wearing a terracotta colored polo

Jeffrey Peterson

Focus areas: Designing and building novel radio telescopes to study dark energy

Simranjeet Singh - man with dark hair wearing dark rimmed glasses

Simranjeet Singh

Focus areas: Magnetism, spin transport and spin dynamics in low-dimensional condensed matter systems

Materials of the Future

MCS researchers are advancing materials science through breakthroughs in nanomaterials, polymers and computational materials discovery. Our work in sustainable materials, machine learning for materials design and green chemistry is reshaping energy storage, biomedicine and next-generation electronics.

Bruce Armitage - male with middle parted hair and goatee, wearing a light shirt and tie

Bruce Armitage

Focus areas: Bioorganic chemistry, fluorescent dyes, DNA nanotechnology, molecular evolution, peptide nucleic acids, molecular recognition of DNA/RNA, G quadruplexes

Mark Bier - man with dark hair wearing a suit coat and button shirt

Mark Bier

Focus areas: Biophysical chemistry, environmental chemistry, analytical chemistry, virus particles, nanoparticles, heavy ion mass spectrometry, membrane inlet mass spectrometry for environmental water analysis

Emile Bominaar - clean shaven older male with rimless glasses and lighter hair in a berry colored polo

Emile Bominaar

Focus areas: Electronic structure; spin; transition-metal complexes; metal clusters; theory; computational; density functional theory; exchange interactions; hyperfine interactions; Mössbauer spectroscopy; magneto optical spectroscopy; magneto chemistry; bioinorganic chemistry

Roberto Gil - smiling older male with light goatee and glasses

Roberto Gil

Focus areas: Nuclear magnetic resonance spectroscopy, residual dipolar couplings, residual chemical shift anisotropy, anisotropic polymer gels, natural products, characterization of nucleic acids, peptides, synthetic polymers, small molecules in general

Olexandr Isayev - male with goatee and wearing a striped gray button shirt

Olexandr Isayev

Focus areas: Theoretical and computational chemistry, machine learning, cheminformatics, drug discovery, computer-aided molecular design, materials informatics

Rongchao Jin - asian male wearing rimless glasses, dressed in a light blue button shirt

Rongchao Jin

Focus areas: Nanoscience, nanoparticles, synthesis, catalysis, optics

Tomasz Kowalewski - brown haired male with a mustache wearing a navy crew neck shirt

Tomasz Kowalewski

Focus areas: Physical chemistry, atomic force microscopy, proximal probe techniques, organic electronics, nano-structured materials, nanographene, self-assembly of organic materials, characterization of nanostructures, device fabrication and characterization

Krzysztof Matyjaszewski - older male with silver-blond hair wearing a dark blue sweater over a blue collared shirt

Krzysztof Matyjaszewski

Focus areas: Polymer synthesis, controlled/living polymerization, macromolecular engineering, bio-related polymers, organic/inorganic hybrids, catalysis, green chemistry

Kevin Noonan - male with short brown hair and wearing a light blue button shirt

Kevin Noonan

Focus areas: Polymer chemistry, organometallics, homogeneous catalysis, organophosphorus chemistry

Linda Peteanu - woman with brown hair and bangs, wearing a lab coat

Linda Peteanu

Focus areas: Photophysics, laser spectroscopy, microscopy, Stark spectroscopy, conjugated materials, nucleic acids, fluorescent labels, plasmonics

Stefanie Sydlik - caucasian blond woman in glasses and a polkadot blouse

Stefanie Sydlik

Focus areas: Polymer science, materials chemistry, biomaterials, electronic materials

Newell Washburn - caucasian male wearing glasses leaning into the camera

Newell Washburn

Focus areas: Materials chemistry, biomaterials, green chemistry, machine learning

David Yaron - caucasian man in a light blue buttoned shirt

David Yaron

Focus areas: Theory, computational, electronic structure theory, machine learning, materials theory, photophysics, spectroscopy

Sara Majetich - woman with straight long hair, wearing a sweater

Sara Majetich

Focus areas: Magnetic nanoparticles that have very uniform sizes, their fundamental behavior and possible applications in data storage media, permanent magnets and biomedicine

Michael Widom - male with wire rimmed glasses

Michael Widom

Focus areas: Theoretical modeling of novel materials in condensed matter and biological physics settings, methods of statistical mechanics, quantum mechanics and computer simulation used to investigate structure, stability and properties of these materials

Irene Fonseca - female with long blond hair and bangs

Irene Fonseca

Focus areas: Mathematical study of shape memory alloys, ferroelectric, magnetic materials, composites, thin structures, phase transitions in fluids and solids and the mathematical analysis of image segmentation, denoising, detexturing and recolorization in computer vision

Giovanni Leoni - dark hair male wearing a collared black shirt

Giovanni Leoni

Focus areas: Variational problems involving material defects, such as dislocations; the epitaxial growth of a thin film over a crystalline substrate; phase field models for anisotropic crystalline energies; phase transitions problems; water waves

Neuroscience

MCS neuroscience research is decoding how neural circuits drive behavior, movement and decision-making. Their work reveals how experience, injury and disease reshape the brain, which is advancing treatments for conditions like Parkinson’s disease, dystonia and stroke.

Alison Barth - distinguished older caucasian lady with chin-length straight blond hair

Alison Barth

Focus areas: Understanding how experience assembles and alters the properties of neural circuits in the cerebral cortex in both normal and disease states

Aryn Gittis - smiling female with medium-length curly brown hair

Aryn Gittis

Focus areas: Neural circuits in the basal ganglia in movement disorders such as Parkinson’s disease and dystonia

Kate Hong - female with dark shoulder-length straight hair

Kate Hong

Focus areas: Determine how cortical and subcortical activity cooperate to mediate sensory-motor transformations in parallel, providing a foundation for understanding behavioral deficits and recovery mechanisms associated with cortical injury

Eric Yttri - male with medium length beard and mustache

Eric Yttri

Focus areas: Establish how neural circuits lead to action selection decisions in impairments like stroke and Parkinson's disease

Mathematical Foundations of Artificial Intelligence

MCS researchers are building the mathematical frameworks that power AI — advancing combinatorics, probability, logic and analysis to create stronger algorithms, optimize computation and tackle high-dimensional problems in data science and machine learning.

Thomas Bohman - male with brown hair and goatee with slightly tinted glasses

Tom Bohman

Focus areas: Extremal and probabilistic combinatorics and discrete mathematical problems

Boris Bukh - male with glasses and curly brown hair in front of chalkboard

Boris Bukh

Focus areas: Combinatorial objects

Clinton Conley - male with brown hair and goatee standing in front of chalkboard

Clinton Conley

Focus areas: Descriptive set theory, equivalence relations arising from measurable group actions or measurable graphs

James Cummings - caucasian male with a whithering smile and dark curly hair

James Cummings

Focus areas: Combinatorial objects, structure theory of linear orderings and posets, rainbow Ramsey theory, strong forcing axioms, new forcing techniques for obtaining consistency results in singular cardinal combinatorics

Florian Frick - dark haired male with a short goatee and dark glasses

Florian Frick

Focus areas: Geometric-topological methods, intersection combinatorics of convex hulls in Euclidean space, inscribing geometric shapes into curves, partitioning a point set by hyperplanes

Alan Frieze - smiling bald male with a short goatee and glasses

Alan Frieze

Focus areas: Probabilistic Combinatorics and its application to Theoretical Computer Science and Operations Research

Rami Grossberg - a serious older male with white hair and glasses

Rami Grossberg

Focus areas: Model theory of mathematical logic, related combinatorial, set-theoretic problems and applications to algebra

Gautum Iyer - a smiling gentleman wearing a eggplant colored shirt

Gautam Iyer

Focus areas: Studies partial differential equations arising in applied mathematics

David Kinderlehrer - smiling older caucasian male in suit holding a geode

David Kinderlehrer

Focus areas: Applied mathematics and analysis of differential equations in materials, cell biology, mechanisms of intracellular transport and models of ion transport

Po-Shen Loh - asian male at chalkboard smiling at camera

Po-Shen Loh

Focus areas: Combinatorics, probability, computer science

Wesley Pegden - dark hair caucasian male slightly angled, looking intently at camera

Wesley Pegden

Focus areas: Probabilistic combinatorics, combinatorial game theory, graph theory, discrete geometry

Agoston Pisztora - older caucasian male with light hair and mustache

Agoston Pisztora

Focus areas: Probabilistic analysis of random fields, certain disordered systems and phase transitions

MCS News - red departmental icon pattern

Ernest Schimmerling

Focus areas: Set theory, hierarchy of large cardinal axioms

Dejan Slepcev - dark-haired distinguished gentleman wearing light blue collared shirt

Dejan Slepčev

Focus areas: Applied analysis, partial differential equations, calculus of variations, optimal transportation, as well as tools of probability, statistics, functional analysis and scientific computation to address applied problems

Richard Statman - older caucasian male in grey crew neck

Richard Statman

Focus areas: Mathematical logic, proof theory and the theory of computation, theory of programming languages (computer science), theory of functional programming, lambda calculus/combinatory logic

Tomasz Tkocz - clean cut caucasian male, brown hair and goatee wearing glasses

Tomasz Tkocz

Focus areas: Analysis, probability and convex geometry, with an emphasis on high-dimensional phenomena, inequalities in information theory

Noel Walkington - smiling older caucasian blond male in a white polo shirt

Noel Walkington

Focus areas: The development and analysis of numerical algorithms required for the approximation of partial differential equations

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