Education & Professional Experience
Ph.D.: Max-Planck-Institute for Polymer Research (2000)
Habilitation: Mainz University (Germany), Computational Physics (2006)
American Physical Society, Biophysical Society, American Chemical Society, German Physical Society (DPG)
Section Editor, The Biophysical Journal
Honors and Awards:
Thomas E. Thompson Award, Biophysical Society (2021)
Otto Hahn-Medal of the Max Planck Society (2001)
Professor of Physics, Carnegie Mellon University, 2016–
Associate Head, Physics Department, Carnegie Mellon University, 2013–2017
Indefinite Tenure, Carnegie Mellon University, 2011
Associate Professor, Carnegie Mellon University, 2007–2016
Project Leader, Max-Planck-Institute for Polymer Research, 2003–2007
Post-doctoral Research: UC Los Angeles, 2000–2003
Biological systems belong to the most fascinating and mysterious entities to be found in our universe, and yet their functioning ultimately rests entirely on very well known laws of nature. In order to understand how biological systems work we do not need to discover previously unknown bits of physics and chemistry; the task is rather to piece the puzzle together and learn how simple laws can explain complex phenomena. Biological Physics is thus a synthetic science, much like Statistical Physics, from whose arsenal of methods it frequently and heavily borrows.
In my research I look at various exciting problems in Biological Physics, dealing, among other things, with lipid membranes, proteins, viruses, or DNA. In all cases I am most interested in phenomena that occur on length scales larger than atomic resolution (i.e., I'm not looking at the specific chemistry) but smaller than whole cells. On these scales many fundamental physical concepts have a big impact on biology, among them thermal fluctuations, cooperativity, self-assembly, or elasticity. For instance, due to their surfactant-like nature individual lipid molecules in an aqueous environment spontaneously aggregate into membranes, which span laterally over scales many orders of magnitude larger than their thickness. These quasi-two-dimensional fluid surfaces resist bending, a continuum elastic concept, but since the associated moduli are only about one order of magnitude bigger than thermal energy, membranes can exhibit large thermal undulations that can very substantially affect their behavior.
In my research I use both theoretical and computational techniques. On the theoretical side I use tools from continuum elastic descriptions, differential geometry, density functional theories, and statistical thermodynamics. On the computational side I mostly use what is known as "coarse-grained simulations". This means that the physical system is not represented on the computer in atomic detail. Rather, a much smaller number of degrees of freedom is used to describe a lipid or a protein. Giving up chemical resolution implies that questions dependent on it cannot be addressed. However, on sufficiently large length scales such detail hardly matters, and the physical properties relevant at this scale, for instance the bending rigidity of a membrane, can be accounted for very appropriately.
The benefits to be reaped from these simplified theoretical and computational descriptions are twofold: First, one can study much larger systems on much longer time scales with much better statistics, and thus access a new arena for physical questions. Second, if a highly simplified model still manages to capture key aspects of the situation at hand, chances are that we have identified the key bits of physics that matter. In other words, we might just have understood something deep about our system that would not be immediately obvious when looking at the original hugely more complicated situation.
Amelie H.R. Koch et al., Probing nanoparticle-membrane interactions by combining amphiphilic diblock co-polymer assembly and plasmonics, J. Phys. Chem. B 124, 742 (2020)
Amirali Hossein and Markus Deserno, Spontaneous curvature, differential stress, and bending modulus of asymmetric lipid membranes, Biophys. J. 118, 624 (2020)
M.M. Terzi, M. Deserno, J.F. Nagle, Mechanical Properties of Lipid Bilayers: A Note on the Poisson Ratio, Soft Matter 15, 9085 (2019)
M.M. Terzi, M.F. Ergüder, M. Deserno, A Consistent Quadratic Curvature-Tilt Theory for Fluid Lipid Membranes, J. Chem. Phys. 151, 164108 (2019)
M. Pannuzzo, Z.A. McDargh, M. Deserno, The role of scaffold reshaping and disassembly in dynamin driven membrane fission, eLife 7:e39441 (2018)
P. Diggins IV, C. Liu, M. Deserno, and R. Potestio, Optimal coarse-grained site selection in elastic network models of biomolecules, J. Chem. Theory Comput. 15, 648 (2018)
P. Bassereau, R. Jin, T. Baumgart, M. Deserno, et al., The 2018 Biomembrane Curvature and Remodeling Roadmap, J. Phys. D: Appl. Phys. 51, 343001 (2018)
M. Pannuzzo, R.D. Tilton, and M. Deserno, Responsive Behavior of a Branched-Chain Polymer Network: a Molecular Dynamics Study, Soft Matter 14, 6485 (2018)
Zachary A. McDargh and Markus Deserno, Dynamin's helical geometry does not destabilize membranes during fission, Traffic 19, 328 (2018)
M. Mert Terzi and Markus Deserno, Novel Tilt-Curvature Coupling in Lipid Membranes, J. Chem. Phys. 147, 084702 (2017)
Z.A. McDargh, P. Vázquez-Montejo, J. Guven, and M. Deserno, Constriction by Dynamin: elasticity vs. adhesion, Biophys. J. 111, 2470 (2016)
X. Wang, M. Deserno, Determining the Pivotal Plane of Fluid Lipid Membranes in Simulations, J. Chem. Phys. 143, 164109 (2015)