Carnegie Mellon University

Roberto Gil

Roberto R. Gil

Research Professor, Chemistry
Director, NMR Center

  • Mellon Institute 302
  • 412-268-4313

Education

1989 Córdoba National University, Córdoba, Argentina, Ph.D.

Research

Nuclear magnetic resonance spectroscopy, residual dipolar couplings, residual chemical shift anisotropy, anisotropic polymer gels, natural products, characterization of nucleic acids, peptides, synthetic polymers and small molecules in general.

Projects

  • Development of New NMR Methodologies for the Analysis of Small Molecules in Anisotropic Media. Residual Dipolar Couplings (RDCs), Residual Chemical Shift Anisotropy (RCSA) and 2H Quadrupolar Splitting.
  • Development of New Polymer Gels as Alignment Media for Small Molecules in Organic Solvents.
  • Characterization of the Structure and Physical of Synthetic Polymers by NMR.
  • Structure Elucidation of Bioactive Natural Products from Plants.
  • NMR Analysis if Small Fragments of Peptide Nuclei Acids and DNA Duplexes.

Publications

2JHH-resolved HSQC: Exclusive determination of geminal proton-proton coupling constants
Núria Marcó, Pau Nolis, Roberto R. Gil, Teodor Parella, Journal of Magnetic Resonance, Volume 282, 2017, Pages 18-26, ISSN 1090-7807, https://doi.org/10.1016/j.jmr.2017.06.014.

Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol
Garcia, M. E.; Woodruff, S. R.; Hellemann, E.; Tsarevsky, N. V.; Gil, R. R., Magn. Reson. Chem. 2017, 55, 206–209.

Measurement of residual chemical shift anisotropies in compressed PMMA gels. Automatic compensation of gel isotropic shift contribution.
Hallwass F, Teles RR, Hellemann E, Griesinger C, Gil RR, Navarro-Vázquez A. Magn Reson Chem. 2018. https://doi.org/10.1002/mrc.4711

Application of Residual Dipolar Couplings and Selective Quantitative NOE to Establish the Structures of Tetranortriterpenoids from Xylocarpus rumphii
Waratchareeyakul, W.; Hellemann, E.; Gil, R. R.; Chantrapromma, K.; Langat, M. K.; Mulholland, D. A., J. Nat. Prod. 2017, 80, 391-402.

Computer-Assisted 3D Structure Elucidation of Natural Products using Residual Dipolar Couplings
Troche-Pesqueira, E.; Anklin, C.; Gil, R. R.; Navarro-Vazquez, A., Angew. Chem., Int. Ed. 2017, 56, 3660-3664.

Homogeneous Catalysis Under Ultradilute Conditions: TAML/NaClO Oxidation of Persistent Metaldehyde
Tang, L. L.; DeNardo, M. A.; Schuler, C. J.; Mills, M. R.; Gayathri, C.; Gil, R. R.; Kanda, R.; Collins, T. J., J. Am. Chem. Soc. 2017, 139, 879-887.

Perfect 1JCH-resolved HSQC: Efficient measurement of one-bond proton-carbon coupling constants along the indirect dimension
Marco, N.; Souza, A. A.; Nolis, P.; Gil, R. R.; Parella, T., J. Magn. Reson. 2017, 276, 37-42.

1JCH NMR Profile: Identification of Key Structural Features and Functionalities by Visual Observation and Direct Measurement of One-Bond Proton-Carbon Coupling Constants
Marco, N.; Souza, A. A.; Nolis, P.; Cobas, C.; Gil, R. R.; Parella, T., J. Org. Chem. 2017, Ahead of Print.

Structural discrimination from in situ measurement of 1DCH and 2DHH residual dipolar coupling constants
Marco, N.; Gil, R. R.; Parella, T., Magn. Reson. Chem. 2017, Ahead of Print.

Conjugated Polymers with Repeated Sequences of Group 16 Heterocycles Synthesized through Catalyst-Transfer Polycondensation
Tsai, C.-H.; Fortney, A.; Qiu, Y.; Gil, R. R.; Yaron, D.; Kowalewski, T.; Noonan, K. J. T., J. Am. Chem. Soc. 2016, 138, 6798-6804.

TAML/H2O2 Oxidative Degradation of Metaldehyde: Pursuing Better Water Treatment for the Most Persistent Pollutants
Tang, L. L.; DeNardo, M. A.; Gayathri, C.; Gil, R. R.; Kanda, R.; Collins, T. J., Environ. Sci. Technol. 2016, 50, 5261-5268.

Nickel-Catalyzed Suzuki Polycondensation for Controlled Synthesis of Ester-Functionalized Conjugated Polymers
Qiu, Y.; Worch, J. C.; Fortney, A.; Gayathri, C.; Gil, R. R.; Noonan, K. J. T., Macromolecules (Washington, DC, U. S.) 2016, 49, 4757-4762.

Synthesis of Polyfuran and Thiophene-Furan Alternating Copolymers Using Catalyst-Transfer Polycondensation
Qiu, Y.; Fortney, A.; Tsai, C.-H.; Baker, M. A.; Gil, R. R.; Kowalewski, T.; Noonan, K. J. T., ACS Macro Lett. 2016, 5, 332-336.

Determination of Relative Configuration from Residual Chemical Shift Anisotropy
Nath, N.; Schmidt, M.; Gil, R. R.; Williamson, R. T.; Martin, G. E.; Navarro-Vazquez, A.; Griesinger, C.; Liu, Y., J. Am. Chem. Soc. 2016, Ahead of Print.

Mechanical Behavior of Polymer Gels for RDCs and RCSAs Collection: NMR Imaging Study of Buckling Phenomena
Hellemann, E.; Teles, R. R.; Hallwass, F.; Barros, W., Jr.; Navarro-Vazquez, A.; Gil, R. R., Chem. - Eur. J. 2016, 22, 16632-16635.

Collection of NMR Scalar and Residual Dipolar Couplings Using a Single Experiment
Gil-Silva, L. F.; Santamaria-Fernandez, R.; Navarro-Vazquez, A.; Gil, R. R., Chem. - Eur. J. 2016, 22, 472-476.

One-Shot Determination of Residual Dipolar Couplings: Application to the Structural Discrimination of Small Molecules Containing Multiple Stereocenters
Castanar, L.; Garcia, M.; Hellemann, E.; Nolis, P.; Gil, R. R.; Parella, T., J. Org. Chem. 2016, 81, 11126-11131.

Book Chapters

“Residual Dipolar Couplings in Small-Molecule NMR”
R.R.Gil
Encyclopedia of Spectroscopy and Spectrometry 3rd.
Edited by Lindon, J.C., Tranter, G.E. and Koppenaal, D.W.
Elsevier. Oxford. 2016. ISBN: 9780128032244.

“Application of Residual Dipolar Couplings to the Structural Analysis of Natural Products”
R. R. Gil and A. Navarro-Vazquez
Title of the book: Modern NMR Approaches to the Structure Elucidation of Natural Products: Data Acquisition and Applications to Compound Classes 1st. 2. 
Edited by Antony Williams, Gary Martin, David Rovnyak. 
The Royal Society of Chemistry.  Cambridge, UK. 2016: 117-176. DOI: 10.1039/9781849734684-00117.

“Application of the Nuclear Overhauser Effect to the Structural Elucidation of Natural Products”
R.R.Gil and A. Navarro-Vazquez
Modern NMR Approaches to the Structure Elucidation of Natural Products: Data Acquisition and Applications to Compound Classes 1st. 2. 
Edited by Antony Williams, Gary Martin, David Rovnyak.
The Royal Society of Chemistry. Cambridge, UK. 2016:1-38. DOI: 10.1039/9781849734684-00001.

“Structural Elucidation of Small Organic Molecules Assisted by NMR in Aligned Media”
Gil, R. R.; Griesinger, C.; Navarro-Vázquez, A.; Sun, H.,
Title of the book: Structure Elucidation in Organic Chemistry. Pag. 281-298.
Edited by Maria-Magdalena Cid and Jorge Bravo.
Wiley-VCH Verlag GmbH & Co. KGaA. 2015 277-321.

“Withanolides and Related Steroids”
Misico, R.I., Nicotra, V.E., Oberti, J.C., Barboza, G., Gil, R.R., Burton, G.
Series: Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, Vol. 94. Pages 127-229.
Edited by: A. Douglas Kinghorn, Heinz Falk and Junichi Kobayashi.
SPRINGER WIEN NEW YORK – 2011.

“Proton and Carbon-13 NMR Studies of Steroids and Triterpenes”
Cordell, G. A., Lin, L.-Z., Gil, R. R.
Title of the Book: SAPONINS USED IN FOOD & AGRICULTURE.
Series:  Advances in Experimental Medicine and Biology
Edited by George R. Waller and Kazuo Yamasaki.
PLENUM PRESS – NEW YORK AND LONDON – 1996

Appointments

YearsPosition
2012–present Research Professor, Carnegie Mellon University
08/2002–present Director, Department of Chemistry NMR Facility, Carnegie Mellon University
07/2008–2012 Associate Research Professor, Carnegie Mellon University
08/2002–06/2008 Research Scientist (Faculty Track), Carnegie Mellon University
06/2001–08/2002 Associate Professor, Córdoba National University, Córdoba, Argentina
04/2001–08/2002 Associate Dean, College of Chemistry, Córdoba National University
02/2000–02/2001 Visiting Assistant Professor, Carnegie Mellon University
03/1995–06/2001 Assistant Professor, Córdoba National University, Córdoba, Argentina
03/1992–02/1995 Visiting Assistant Professor, University of Illinois at Chicago
07/1989–02/1992 Postdoctoral Fellow, Córdoba National University, Córdoba, Argentina

Awards and Distinctions

YearsAward
1996 Top Ten Youngsters of the Year. Granted by the Stock Exchange Market of Córdoba. Córdoba. Argentina.
1996 Top Twelve Outstanding Citizens and/or Institutions of the Year of Catamarca Province - Argentina. Sponsored by the City of Catamarca and Catamarca Province Governments.
1996 CATAMARCA 96. Given to the best of the twelve candidates above. Sponsored by the City of Catamarca and Catamarca Province Governments.
1992 National Research Council of Argentina — 2 year International Fellowship (University of Illinois at Chicago).
1988 National Research Council of Argentina — 4 year Doctoral Fellowship (Córdoba National University, Córdoba, Argentina).
04/1983–12/1983 Undergraduate Research Fellowship. Córdoba National University, Natural Products Laboratory — Organic Chemistry Department.
07/1983–11/1983 Undergraduate Research Fellowship. The Air Force of Argentina to work at the laboratories of the Air Force in Córdoba. Field: UV-Vis and Infrared Spectroscopy.