Carnegie Mellon University

Frank Heinrich

Associate Research Professor
and NIST Associate

Biological Physics Experiment
Off-campus at NIST Center for Neutron Research

lab website

Prof. Frank Heinrich

Education & Professional Experience

Ph.D.: University of Leipzig (Germany), Nuclear Physics (2005)

Professional Societies:
Neutron Scattering Society of America
Biophysical Society 

Curriculum Vitae

Associate Research Professor, Carnegie Mellon University, 2016–
Assistant Research Professor, Carnegie Mellon University, 2011–16
Research Physicist, Carnegie Mellon University, 2008–11
Staff Scientist, The NIST Center for Neutron Research, 2008–
Associate, The NIST Center for Neutron Research, 2005–
Post-doctoral Research: Johns Hopkins University, 2005, and Carnegie Mellon University, 2005–08

Research Interests

My research concerns the structure of disease-relevant proteins, peptides, and small molecules at lipid membranes. For example, I am interested in the structural foundations of cell signaling in cancer. I utilize a broad range of surface-sensitive techniques, including electrical impedance spectroscopy, surface plasmon resonance, and neutron reflectometry. Physically, I spend most of my time in Gaithersburg, Maryland, where I am a research associate at the Center for Neutron Research at the National Institute of Standards and Technology. In this capacity, I am involved in developing future-generation neutron scattering instrumentation for soft-matter and biological research. I am also committed to aiding academic and industrial scientists in performing successful research using neutron scattering techniques.

Recent Publications

Michalak D. J., Unger B., Lorimer E., Grishaev A., Williams C. L., Heinrich F., Lösche M., Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558. Biophysical Journal (2022)

Heinrich F., Van Q. N., Jean-Francois F., Stephen A. G., Lösche M., Membrane-Bound KRAS Approximates an Entropic Ensemble of Configurations. Biophysical Journal 120:4055 (2021)

Comert F., Heinrich F., Chowdhury A., Schoeneck M., Darling C., Anderson K. W., Daben M., Libardo M. D. J., Angeles-Boza A. M., Silin V., Cotten M. L., Mihailescu M., Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption. Scientific Reports 11:12620 (2021)

Soubias O., Pant S., Heinrich F., Zhang Y., Roy N. S., Li J., Jian X., Yohe M. E., Randazzo P. A., Lösche M., Tajkhorshid E., Byrd R. A., Membrane surface recognition by the ASAP1 PH domain and consequences for interactions with the small GTPase Arf1. Science Advances 6:eabd1882 (2020)

Brian P. Josey, Frank Heinrich, Vitalii Silin, and Mathias Lösche, Association of Model Neurotransmitters with Lipid Bilayer Membranes, Biophys. J. 118, 1044 (2020)

David P. Hoogerheide, Frank Heinrich, Brian P. Maranville, and Cahrles F. Majkrzak, Accurate background correction in neutron reflectometry studies of soft condensed matter films in contact with fluid reservoirs, J. Appl. Crystal. 53, 15 (2020)

Bradley W. Treece et al., Optimization of reflectometry experiments using information theory, J. Appl. Crystal. 52, 47 (2019)

Rana Ashkar et al., Progress and Prospects for Neutron Scattering in the Biological Sciences, Acta Cryst. D 74, 1129 (2018)

Fernando G. Dupuy et al., Selective interaction of colistin with lipid model membranes, Biophys. J. 114, 919 (2018)

Cavan K. Kalonia et al., Protein Adsorption and Layer Formation at the Stainless Steel-Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody, Mol. Pharmaceutics 15, 1319 (2018)

Juan M. Vanegas et al., Insertion of Dengue E into Lipid Bilayers by Neutron Reflectivity and Molecular Dynamics Simulations, Biochim. Biophys. Acta 1860, 1216 (2018)


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ORCID Researcher ID