Carnegie Mellon University

Frank Heinrich

Associate Research Professor
and NIST Associate

Biological Physics Experiment
Off-campus at NIST Center for Neutron Research

lab website

Prof. Frank Heinrich

Education & Professional Experience

Ph.D.: University of Leipzig (Germany), Nuclear Physics (2005)

Professional Societies:
American Physical Society
Biophysical Society

Curriculum Vitae

Associate Research Professor, Carnegie Mellon University, 2016–
Assistant Research Professor, Carnegie Mellon University, 2011–16
Research Physicist, Carnegie Mellon University, 2008–11
Staff Scientist, The NIST Center for Neutron Research, 2008–
Associate, The NIST Center for Neutron Research, 2005–
Post-doctoral Research: Johns Hopkins University, 2005, and Carnegie Mellon University, 2005–08

Research Interests

My research concerns disease-relevant proteins, peptides, and small molecules at interfaces and, in particular, interacting with lipid membranes. For example, I am interested in the structural foundations of the function of the T-Cell receptor, which enables the T-Cell to recognize foreign pathogens and initiate a immune response in the body. I utilize a broad range of surface-sensitive techniques including electrical impedance spectroscopy, surface plasmon resonance, and neutron reflectometry. Physically, I spend most of my time in Gaithersburg, Maryland, where I am a research associate at the Center for Neutron Research at the National Institute of Standards and Technology. In this capacity I am involved in the development of future-generation neutron scattering instrumentation for soft-matter and biological research and I am committed to aiding academic and industrial scientists performing successful research using neutron scattering techniques.

Recent Publications

Brian P. Josey, Frank Heinrich, Vitalii Silin, and Mathias Lösche, Association of Model Neurotransmitters with Lipid Bilayer Membranes, Biophys. J. 118, 1044 (2020)

David P. Hoogerheide, Frank Heinrich, Brian P. Maranville, and Cahrles F. Majkrzak, Accurate background correction in neutron reflectometry studies of soft condensed matter films in contact with fluid reservoirs, J. Appl. Crystal. 53, 15 (2020)

Bradley W. Treece et al., Optimization of reflectometry experiments using information theory, J. Appl. Crystal. 52, 47 (2019)

Rana Ashkar et al., Progress and Prospects for Neutron Scattering in the Biological Sciences, Acta Cryst. D 74, 1129 (2018)

Fernando G. Dupuy et al., Selective interaction of colistin with lipid model membranes, Biophys. J. 114, 919 (2018)

Cavan K. Kalonia et al., Protein Adsorption and Layer Formation at the Stainless Steel-Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody, Mol. Pharmaceutics 15, 1319 (2018)

Juan M. Vanegas et al., Insertion of Dengue E into Lipid Bilayers by Neutron Reflectivity and Molecular Dynamics Simulations, Biochim. Biophys. Acta 1860, 1216 (2018)

Zhiping Jiang et al., Segmental Deuteration of α-Synuclein for Neutron Reflectometry on Tethered Bilayers, J. Chem. Phys. Lett. 8, 29 (2017)

Tadas Ragaliauskas et al., Fast formation of low-defect-density tethered bilayers by fusion of multilamellar vesicles, Biochim. Biophys. Acta 1859, 669 (2017)

Marilia Barros et al., Membrane Binding of HIV-1 Matrix Protein: Dependence on Bilayer Composition and Protein Lipidation, J. Virology 90, 4544 (2016)

Frank Heinrich, Deuteration in Biological Neutron Reflectometry, Methods Enzymol. 566, 211 (2016)

More Publications:
ORCID Researcher ID