Carnegie Mellon University

We have two Bruker 500 MHz Avance NMR spectrometers. We can perform Multinuclear and Multidimensional NMR Experiments in both Direct and Inverse Detection Mode using Gradient-Assisted Spectroscopy (GRASP). (Funded in part by NSF grant # CHE-9808188 and CHE-1039870)

Capabilities:

Our Facility is capable of performing a wide variety of NMR experiment. Some of the most common experiments are listed below by category.

Routine 1D NMR Spectroscopy

  • Standard 1H, 13C, 31P, 19F, 15N, 29Si NMR experiments

Dynamic NMR Spectroscopy

  • High and Low Temperature Experiments
  • Saturation Transfer Experiments
  • EXSY (EXchange SpectroscopY)

1D Multipulse Sequences

  • Measurement of the Spin-Lattice Relaxation Time T1
  • Measurement of the Spin-Spin Relaxation Time T2
  • 13C DEPT- 45, 90 and135
  • Water Suppression by Presaturation

Multinuclear Multidimensional NMR Spectroscopy

  • 2D Homonuclear Correlation Experiments: COSY-Experiment and its variants, NOESY, ROESY, TOCSY.
  • 2D Heteronuclear Correlation Experiments: HSQC, HMBC, HSQC-TOCSY.

NMR Spectroscopy with Pulsed Field Gradients

  • Measurement of Diffusion Constant using the Pulsed Gradient Spin-Echo Experiment (DOSY)
  • WATERGATE (water suppression experiment)
  • Water Suppression by Excitation Sculpting
  • Plus all the Gradient-Selected Multidimensional Experiments