Isaac Garcia Bosch

Associate Professor, Chemistry

Education

Postdoctoral Fellow, Johns Hopkins University, 2012–2015
Ph.D. in Chemistry, University of Girona, 2011
M.S. in Inorganic Chemistry, University of Girona, 2008
B.S. in Chemistry, University of Girona, 2006

Research

Keywords: Bio-Inspired Catalysts for Practical Organic Synthesis, 3D Metal Complexes (Structure, Spectroscopy and Reactivity) 

Publications

Practical One-Pot Multistep Synthesis of 2H-1,3-Benzoxazines Using Copper, Hydrogen Peroxide, and Triethylamine
Trammell, R.; Cordova, A.; Zhang, S.; Goswami, S.; Murata, R..; Siegler, M. A.; and Garcia-Bosch, I.* Eur. J. Org. Chem. 2021, 2021, 4536. DOI: 10.1002/ejoc.202100783

De Novo Design of a Self-Assembled Artificial Copper Peptide that Activates and Reduces Peroxide
Mitra, S.; Prakash, D.; Rajabimoghadam, K.; Wawrzak, Z.; Prasad, P.; Wu, T.; Misra, S. K.; Sharp, J. S.; Garcia-Bosch, I.; Chakraborty, S.* ACS Catal. 2021, 11, 10267-10278. DOI: 10.1021/acscatal.1c02132

Cu-promoted intramolecular hydroxylation of CH bonds using directing groups with varying denticity
Zhang, S.; Trammell, R.; Cordova, A.; Siegler, M. A.; Garcia-Bosch, I.* J. Inorg. Biochem. 2021, 223, 111557. DOI: 10.1016/j.jinorgbio.2021.111557

Mononuclear and dinuclear copper complexes of tridentate redox-active ligands with tunable H-bonding donors: structure, spectroscopy and H+/e− reactivity
Wu, T.; Musgrove, J.; Siegler, M. A.; and Garcia-Bosch, I.* Chem. Asian. J., 2021, 16, 1608-1618. Early Career Research Collection. DOI: 10.1002/asia.202100286

Synthetic Copper Complexes as Cu-Dependent Monooxygenase Model Systems and Catalysts for Dioxygen Reduction and Water Oxidation
Trammell, Rachel, and Isaac Garcia-Bosch. (2021)

Structure, spectroscopy and reactivity of a mononuclear copper hydroxide complex in three molecular oxidation states
Wu, T.; MacMillan, S. N.; Rajabimoghadam, K.; Siegler, M. A.; Lancaster, K. M.*; and Garcia-Bosch, I.* J. Am. Chem. Soc., 2020, 142, 12265-12276. DOI:10.1021/jacs.0c03867

Tunable intramolecular multicenter H-bonding interactions in first-row metal complexes bearing bidentate redox-active ligands
Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; and Garcia- Bosch, I*. J. Coord. Chem. 2019, 1335. DOI:10.1080/00958972.2019.1624728

Copper-Directed Hydroxylation of sp2 and sp3 C-H Bonds
Trammell, R.; D’Amore, L; Cordova, A.; Polunin P.; Xie, N.; Siegler, M. A.; Belanzoni, P.; Marcel Swart, M.*; and Garcia-Bosch, I.* Inorg. Chem. 2019, 58, 7584. DOI: 10.1021/acs.inorgchem.9b00901

Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations
Trammell, R.; Rajabimoghadam, K.; and Garcia-Bosch, I.* Chem. Rev., 2019, 119, 2954. DOI: 10.1021/acs.chemrev.8b00368

Catalytic Aerobic Oxidation of Alcohols by Copper Complexes Bearing Redox-Active Ligands with Tunable H-Bonding Groups
Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; Swart, M.*; and Garcia-Bosch, I.* J. Am. Chem. Soc., 2018, 140, 16625.DOI: 10.1021/jacs.8b08748

Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C–H Bonds
Trammell, R.; See, Y. Y.; Herrmann, A. T.; Xie, N.; Díaz, D. E.; Siegler, M. A.; Baran, P. S.; Garcia-Bosch, I.* J. Org. Chem. 2017, 82, 7887. DOI: 10.1021/acs.joc.7b01069

Copper-Catalyzed Oxidation of Alkanes under Mild Conditions
Garcia-Bosch, I.*, Synlett, 2017, 28, 1237. (Synpacts Article). DOI: 10.1055/s-0036-1590202 (Synpacts Article)

Substrate and Lewis Acid Coordination Promote O–O Bond Cleavage of an Unreactive L2CuII2(O22–) Species to Form L2CuIII2(O)2 Cores with Enhanced Oxidative Reactivity
Garcia-Bosch, I.*, Cowley, R. E.; Díaz, D. E.: Peterson, R. L.: Solomon, E. I.*; and Karlin, K. D.* J. Am. Chem. Soc., 2017, 139, 3186. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b12990

Critical Aspects of Heme–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–Operoxo Breakage versus Reductive O–O Cleavage Chemistry
Adam, S. M.; Garcia-Bosch, I., Schaefer A. W.; Sharma, S. K.; Siegler, M. A., Solomon, E. I.*; and Karlin, K. D.* J. Am. Chem. Soc., 2017, 139, 472. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b11322

Copper-Catalyzed Oxidation of Alkanes with H2O2 under a Fenton-like Regime
Garcia-Bosch, I.*; Siegler, M. A. Angew. Chem. Int. Ed., 2016, 55, 12873. DOI: 10.1002/anie.201607216

Dioxygen Activation by a Macrocyclic Copper Complex Leads to a Cu2O2 Core with Unexpected Structure and Reactivity
Garcia-Bosch, I.; Cowley, R. E.; Díaz, D. E.; Siegler, M. A.; Nam, W.; Solomon, E. I. and Karlin, K.D. Chem. Eur. J., 2016, 22, 5133. DOI: 10.1002/chem.201600551

Synthetic Heme/Copper Assemblies: Toward an Understanding of Cytochrome c Oxidase Interactions with Dioxygen and Nitrogen Oxides
Hematian, S.; Garcia-Bosch, I.; and Karlin, K. D. Acc. Chem. Res., 2015, 48, 2462. DOI: 10.1021/acs.accounts.5b00265 Special issue “Synthesis in Biological Inorganic Chemistry”

Structural and Reactivity Models for Copper Oxygenases: Cooperative Effects and Novel Reactivities
Serrano-Plana, J.; Garcia-Bosch, I.; Company, A.; and Costas, M. Acc. Chem. Res., 2015, 48, 2397. DOI: 10.1021/acs.accounts.5b00187. Special issue “Synthesis in Biological Inorganic Chemistry”