Carnegie Mellon University

Isaac Garcia Bosch

Isaac Garcia Bosch

Associate Professor, Chemistry


2012-2015    Postdoctoral Fellow, Johns Hopkins University
2011    Ph.D. in Chemistry, University of Girona
2008    M.S. in Inorganic Chemistry, University of Girona
2006    B.S. in Chemistry, University of Girona


Bio-Inspired Catalysts for Practical Organic Synthesis, 3D Metal Complexes (Structure, Spectroscopy and Reactivity) 


Trammell, R.; Cordova, A.; Zhang, S.; Goswami, S.; Murata, R..; Siegler, M. A.; and Garcia-Bosch, I.* “Practical One-Pot Multistep Synthesis of 2H-1,3-Benzoxazines Using Copper, Hydrogen Peroxide, and Triethylamine”. Eur. J. Org. Chem. 2021, 2021, 4536. DOI: 10.1002/ejoc.202100783

Mitra, S.; Prakash, D.; Rajabimoghadam, K.; Wawrzak, Z.; Prasad, P.; Wu, T.; Misra, S. K.; Sharp, J. S.; Garcia-Bosch, I.; Chakraborty, S.* De Novo Design of a Self-Assembled Artificial Copper Peptide that Activates and Reduces Peroxide. ACS Catal. 2021, 11, 10267-10278. DOI: 10.1021/acscatal.1c02132

Zhang, S.; Trammell, R.; Cordova, A.; Siegler, M. A.; Garcia-Bosch, I.* “Cu-promoted intramolecular hydroxylation of CH bonds using directing groups with varying denticity.” J. Inorg. Biochem. 2021, 223, 111557. DOI: 10.1016/j.jinorgbio.2021.111557

Wu, T.; Musgrove, J.; Siegler, M. A.; and Garcia-Bosch, I.* “Mononuclear and dinuclear copper complexes of tridentate redox-active ligands with tunable H-bonding donors: structure, spectroscopy and H+/e− reactivity” Chem. Asian. J., 2021, 16, 1608-1618. Early Career Research Collection. DOI: 10.1002/asia.202100286

Trammell, Rachel, and Isaac Garcia-Bosch. “Synthetic Copper Complexes as Cu-Dependent Monooxygenase Model Systems and Catalysts for Dioxygen Reduction and Water Oxidation.” (2021).

Wu, T.; MacMillan, S. N.; Rajabimoghadam, K.; Siegler, M. A.; Lancaster, K. M.*; and Garcia-Bosch, I.* “Structure, spectroscopy and reactivity of a mononuclear copper hydroxide complex in three molecular oxidation states”. J. Am. Chem. Soc., 2020, 142, 12265-12276. DOI:10.1021/jacs.0c03867

Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; and Garcia- Bosch, I*. “Tunable intramolecular multicenter H-bonding interactions in first-row metal complexes bearing bidentate redox-active ligands”. J. Coord. Chem. 2019, 1335. DOI:10.1080/00958972.2019.1624728

Trammell, R.; D’Amore, L; Cordova, A.; Polunin P.; Xie, N.; Siegler, M. A.; Belanzoni, P.; Marcel Swart, M.*; and Garcia-Bosch, I.* “Copper-Directed Hydroxylation of sp2 and sp3 C-H Bonds”. Inorg. Chem. 2019, 58, 7584. DOI: 10.1021/acs.inorgchem.9b00901

Trammell, R.; Rajabimoghadam, K.; and Garcia-Bosch, I.* “Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations”. Chem. Rev., 2019, 119, 2954. DOI: 10.1021/acs.chemrev.8b00368

Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; Swart, M.*; and Garcia-Bosch, I.* “Catalytic Aerobic Oxidation of Alcohols by Copper Complexes Bearing Redox-Active Ligands with Tunable H-Bonding Groups”. J. Am. Chem. Soc., 2018, 140, 16625.DOI: 10.1021/jacs.8b08748

Trammell, R.; See, Y. Y.; Herrmann, A. T.; Xie, N.; Díaz, D. E.; Siegler, M. A.; Baran, P. S.; Garcia-Bosch, I.* “Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C–H Bonds”. J. Org. Chem. 2017, 82, 7887. DOI: 10.1021/acs.joc.7b01069

Garcia-Bosch, I.*, “Copper-Catalyzed Oxidation of Alkanes under Mild Conditions”. Synlett, 2017, 28, 1237. (Synpacts Article). DOI: 10.1055/s-0036-1590202 (Synpacts Article).

Garcia-Bosch, I.*, Cowley, R. E.; Díaz, D. E.: Peterson, R. L.: Solomon, E. I.*; and Karlin, K. D.* “Substrate and Lewis Acid Coordination Promote O–O Bond Cleavage of an Unreactive L2CuII2(O22–) Species to Form L2CuIII2(O)2 Cores with Enhanced Oxidative Reactivity.” J. Am. Chem. Soc., 2017, 139, 3186. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b12990

Adam, S. M.; Garcia-Bosch, I., Schaefer A. W.; Sharma, S. K.; Siegler, M. A., Solomon, E. I.*; and Karlin, K. D.* “Critical Aspects of Heme–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–Operoxo Breakage versus Reductive O–O Cleavage Chemistry.” J. Am. Chem. Soc., 2017, 139, 472. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b11322

Garcia-Bosch, I.*; Siegler, M. A. “Copper-Catalyzed Oxidation of Alkanes with H2O2 under a Fenton-like Regime”. Angew. Chem. Int. Ed., 2016, 55, 12873. DOI: 10.1002/anie.201607216

Garcia-Bosch, I.; Cowley, R. E.; Díaz, D. E.; Siegler, M. A.; Nam, W.; Solomon, E. I. and Karlin, K.D. “Dioxygen Activation by a Macrocyclic Copper Complex Leads to a Cu2O2 Core with Unexpected Structure and Reactivity”. Chem. Eur. J., 2016, 22, 5133. DOI: 10.1002/chem.201600551

Hematian, S.; Garcia-Bosch, I.; and Karlin, K. D. “Synthetic Heme/Copper Assemblies: Toward an Understanding of Cytochrome c Oxidase Interactions with Dioxygen and Nitrogen Oxides” Acc. Chem. Res., 2015, 48, 2462. DOI: 10.1021/acs.accounts.5b00265 Special issue “Synthesis in Biological Inorganic Chemistry”.

Serrano-Plana, J.; Garcia-Bosch, I.; Company, A.; and Costas, M. “Structural and Reactivity Models for Copper Oxygenases: Cooperative Effects and Novel Reactivities”. Acc. Chem. Res., 2015, 48, 2397. DOI: 10.1021/acs.accounts.5b00187. Special issue “Synthesis in Biological Inorganic Chemistry”.