Isaac Garcia Bosch

Associate Professor, Chemistry

Education

Postdoctoral Fellow, Johns Hopkins University, 2012–2015
Ph.D. in Chemistry, University of Girona, 2011
M.S. in Inorganic Chemistry, University of Girona, 2008
B.S. in Chemistry, University of Girona, 2006

Research

Keywords: Bio-Inspired Catalysts for Practical Organic Synthesis, 3D Metal Complexes (Structure, Spectroscopy and Reactivity) 

The Garcia-Bosch lab at Carnegie Mellon University (previously at Southern Methodist University) takes inspiration from metalloenzymes to develop metal complexes able to catalyze organic transformations under environmentally benign conditions using cheap reagents (i.e. 1st row transition metals, such as Cu, and green oxidants such as O2 or H2O2; see our review on this subject Chem. Rev., 2019, 119, 2954).

Projects

Functional Synthetic Models of Cu-dependent Monooxygenases (NIH)

Catalysis with copper complexes bearing redox-active ligands with tunable hydrogen-bonding donors (NSF CAREER)

Publications

Tuning the Thermochemistry and Reactivity of a Series of Cu-based Electron-Coupled-Proton Buffers
Wu, T.; Puri, A.; Qui, Y.L.; Ye, D.; Sarma, R.; Wang, Y.; Kowalewski, T.; Siegler, M. A.; Swart, M.; and Garcia-Bosch, I.* Inorg. Chem., 63, 9014-9025. DOI: 10.1021/acs.inorgchem.4c00835 2024

Regioselective hydroxylation of unsymmetrical benzophenones using Cu, H2O2 and imine directing groups via formation of an electrophilic cupric hydroperoxide core
Zhang, S.; Goswami, S.; Schulz, K. H. G., Gill, K., Yin, X., Hwang, J., Wiese, J.; Jaffer, I.; Gil, R. R.; and Garcia-Bosch, I.* J. Org. Chem., 89, 2622. DOI: 10.1021/acs.joc.3c02647 2024

Mimicking the Reactivity of LPMOs with a Mononuclear Cu Complex
Sagar, K.; Kim, M.; Wu, T.; Zhang, S.; Boominar, E.; Siegler, M. A.; Hendrich, M. P.*; and Garcia-Bosch, I.* Eur. J. Inorg. Chem., e202300774. DOI: https://doi.org/10.1002/ejic.202300774 2024

Geometric Control of Cu, Ni and Pd Complexes via Intramolecular H-Bonding Interactions
Puri, A.; McAninch, A.; Shu, S.; Rajabimoghadam, K.; Siegler, M. A., Hendrich, M. P.; Swart, M.; Garcia-Bosch, I. Inorg. Chim. Acta, 561, 121844. DOI: 10.1016/j.ica.2023.121844 2024

A 4H+/4e– Electron-Coupled-Proton Buffer Based on a Mononuclear Cu Complex
Wu, T.; Rajabimoghadam, K.; Puri, A.; Hebert, D. D.; Qui, Y.L.; Eichelberger S.; Siegler, M. A.; Swart, M.*; Hendrich, M. P.*; and Garcia-Bosch, I.* J. Am. Chem. Soc., 144, 16905. DOI: 10.1021/jacs.2c05454 2022

Practical One-Pot Multistep Synthesis of 2H-1,3-Benzoxazines Using Copper, Hydrogen Peroxide, and Triethylamine
Trammell, R.; Cordova, A.; Zhang, S.; Goswami, S.; Murata, R..; Siegler, M. A.; and Garcia-Bosch, I.* Eur. J. Org. Chem. 2021, 4536. DOI: 10.1002/ejoc.202100783 2021

De Novo Design of a Self-Assembled Artificial Copper Peptide that Activates and Reduces Peroxide
Mitra, S.; Prakash, D.; Rajabimoghadam, K.; Wawrzak, Z.; Prasad, P.; Wu, T.; Misra, S. K.; Sharp, J. S.; Garcia-Bosch, I.; Chakraborty, S.* ACS Catal., 11, 10267-10278. DOI: 10.1021/acscatal.1c02132 2021

Cu-promoted intramolecular hydroxylation of CH bonds using directing groups with varying denticity
Zhang, S.; Trammell, R.; Cordova, A.; Siegler, M. A.; Garcia-Bosch, I.* J. Inorg. Biochem., 223, 111557. DOI: 10.1016/j.jinorgbio.2021.111557 2021

Mononuclear and dinuclear copper complexes of tridentate redox-active ligands with tunable H-bonding donors: structure, spectroscopy and H+/e− reactivity
Wu, T.; Musgrove, J.; Siegler, M. A.; and Garcia-Bosch, I.* Chem. Asian. J., 16, 1608-1618. Early Career Research Collection. DOI: 10.1002/asia.202100286 2021

Synthetic Copper Complexes as Cu-Dependent Monooxygenase Model Systems and Catalysts for Dioxygen Reduction and Water Oxidation
Trammell, Rachel, and Isaac Garcia-Bosch. 2021

Structure, spectroscopy and reactivity of a mononuclear copper hydroxide complex in three molecular oxidation states
Wu, T.; MacMillan, S. N.; Rajabimoghadam, K.; Siegler, M. A.; Lancaster, K. M.*; and Garcia-Bosch, I.* J. Am. Chem. Soc., 142, 12265-12276. DOI:10.1021/jacs.0c03867 2020

Tunable intramolecular multicenter H-bonding interactions in first-row metal complexes bearing bidentate redox-active ligands
Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; and Garcia- Bosch, I*. J. Coord. Chem., 1335. DOI:10.1080/00958972.2019.1624728 2019

Copper-Directed Hydroxylation of sp2 and sp3 C-H Bonds
Trammell, R.; D’Amore, L; Cordova, A.; Polunin P.; Xie, N.; Siegler, M. A.; Belanzoni, P.; Marcel Swart, M.*; and Garcia-Bosch, I.* Inorg. Chem., 58, 7584. DOI: 10.1021/acs.inorgchem.9b00901 2019

Copper-Promoted Functionalization of Organic Molecules: from Biologically Relevant Cu/O2 Model Systems to Organometallic Transformations
Trammell, R.; Rajabimoghadam, K.; and Garcia-Bosch, I.* Chem. Rev., 119, 2954. DOI: 10.1021/acs.chemrev.8b00368 2019

Catalytic Aerobic Oxidation of Alcohols by Copper Complexes Bearing Redox-Active Ligands with Tunable H-Bonding Groups
Rajabimoghadam, K.; Darwish Y.; Bashir U.; Pitman, D.; Eichelberger S.; Siegler, M. A.; Swart, M.*; and Garcia-Bosch, I.* J. Am. Chem. Soc., 140, 16625.DOI: 10.1021/jacs.8b08748 2018

Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C–H Bonds
Trammell, R.; See, Y. Y.; Herrmann, A. T.; Xie, N.; Díaz, D. E.; Siegler, M. A.; Baran, P. S.; Garcia-Bosch, I.* J. Org. Chem., 82, 7887. DOI: 10.1021/acs.joc.7b01069 2017

Copper-Catalyzed Oxidation of Alkanes under Mild Conditions
Garcia-Bosch, I.*, Synlett, 28, 1237. (Synpacts Article). DOI: 10.1055/s-0036-1590202 (Synpacts Article) 2017

Substrate and Lewis Acid Coordination Promote O–O Bond Cleavage of an Unreactive L2CuII2(O22–) Species to Form L2CuIII2(O)2 Cores with Enhanced Oxidative Reactivity
Garcia-Bosch, I.*, Cowley, R. E.; Díaz, D. E.: Peterson, R. L.: Solomon, E. I.*; and Karlin, K. D.* J. Am. Chem. Soc., 139, 3186. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b12990 2017

Critical Aspects of Heme–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–Operoxo Breakage versus Reductive O–O Cleavage Chemistry
Adam, S. M.; Garcia-Bosch, I., Schaefer A. W.; Sharma, S. K.; Siegler, M. A., Solomon, E. I.*; and Karlin, K. D.* J. Am. Chem. Soc., 139, 472. Note: I.G.-B. affiliated with SMU. DOI: 10.1021/jacs.6b11322 2017

Copper-Catalyzed Oxidation of Alkanes with H2O2 under a Fenton-like Regime
Garcia-Bosch, I.*; Siegler, M. A. Angew. Chem. Int. Ed., 55, 12873. DOI: 10.1002/anie.201607216 2016

Dioxygen Activation by a Macrocyclic Copper Complex Leads to a Cu2O2 Core with Unexpected Structure and Reactivity
Garcia-Bosch, I.; Cowley, R. E.; Díaz, D. E.; Siegler, M. A.; Nam, W.; Solomon, E. I. and Karlin, K.D. Chem. Eur. J., 22, 5133. DOI: 10.1002/chem.201600551 2016

Synthetic Heme/Copper Assemblies: Toward an Understanding of Cytochrome c Oxidase Interactions with Dioxygen and Nitrogen Oxides
Hematian, S.; Garcia-Bosch, I.; and Karlin, K. D. Acc. Chem. Res., 48, 2462. DOI: 10.1021/acs.accounts.5b00265 Special issue “Synthesis in Biological Inorganic Chemistry” 2015

Structural and Reactivity Models for Copper Oxygenases: Cooperative Effects and Novel Reactivities
Serrano-Plana, J.; Garcia-Bosch, I.; Company, A.; and Costas, M. Acc. Chem. Res., 48, 2397. DOI: 10.1021/acs.accounts.5b00187. Special issue “Synthesis in Biological Inorganic Chemistry” 2015