Carnegie Mellon University

Stephanie A. Tristram-Nagle

Research Professor Emerita

Biological Physics Experiment
Wean Hall 6415

lab website 

Prof. Stephanie Tristram-Nagle

Education & Professional Experience

PhD: UC Berkeley (1981)

Professional Societies:
American Physical Society, Biophysical Society, Association for Women in Science, AAAS

Honors and Awards:
Biophysical Society Avanti Award in Lipids (2003)

Curriculum ViTAE

Research Professor, Carnegie Mellon University, 2008–16
Associate Research Professor, Carnegie Mellon University, 2005–08
Senior Research Biologist, Carnegie Mellon University, 1998–2005
Research Biologist, Carnegie Mellon University, 1986–98
Post-doctoral Research: Carnegie Mellon University, 1982–86

Research Interests

Stephanie Tristram-Nagle (emerita) actively performs research into lipid membrane structure, properties and thermodynamics. Her lab explores the structure of biological phospholipids, lipid/peptide and lipid/cholesterol mixtures using oriented samples on substrates or large unilamellar vesicles using X-ray diffuse scattering with a Rigaku rotating anode and CCD detector here at CMU, and with synchrotron radiation at the Cornell High Energy Synchrotron Source (CHESS). Her current focus is on the interaction of antimicrobial peptides with bacterial membrane mimics. The X-ray data yield not only structure, such as lipid area and membrane thickness, but also the bending and compression moduli of the membranes. Tristram-Nagle collaborates with MD simulators to compare experimental with simulated results. Her lab also measures lipid volumes with an Anton-Paar 5000M densitometer and D2O-H2O mixtures.


Selected Publications

Skandani, A., Clement, J.A., Tristram-Nagle, S., Shankar, M.R., Aliphatic flexible spacer length controls photomechanical response in compact, ordered liquid crystalline polymer networks. Polymer 133:30-39 (2017)

O’Neil, L., Andenoro, K., Pagano, I., Carroll, L. Langer, L., Dell, Z., Perera, D., Treece, B.W., Heinrich, F., Lösche, M., Nagle, J.F.,  Tristram-Nagle, S., HIV-1 Matrix-31 Membrane Binding Peptide Interacts Differently with Membranes Containing PS vs. PI(4,5)P2, Biochimica et Biophysica Acta 1858: 3071-3081 (2016)

Stetten, A.Z., Moraca, G., Corcoran, T.E.,  Tristram-Nagle, S., Garoff, S., Przybycien, T.M., Tilton, R.D., Enabling Marangoni Flow at Air-Liquid Interfaces Through Deposition of Aerosolized Lipid Dispersions, Journal of Colloid and Interface Science 484:270-278 (2016)

Nagle, J.F., M.S. Jablin, Tristram-Nagle, S., Sugar Does Not Affect the Bending and Tilt Moduli of Simple Lipid Bilayers, Chemistry and Physics of Lipids 196:76-80 (2016)

Nagle, J.F., Akabori,  K., Treece, W., Tristram-Nagle, S., Determination of Mosaicity in Oriented Stacks of Lipid Bilayers.  Soft Matter 12:1884-1891 (2016)

Tristram-Nagle, S.,  Use of X-Ray and Neutron Scattering Methods with Volume Measurements to Determine Lipid Bilayer Structure and Number of Water Molecules/Lipid, Membrane Hydration, The Role of Water in the Structure and Function of Biological Membranes, Subcellular Biochemistry Vol. 71. Ed. E. Anibal Disalvo, Springer International Publishing AG, Switzerland (2015)

Neale, C., Huang, K., Garcia, A.E.,  Tristram-Nagle, S., Penetration of HIV-1 Tat47-57 into PC/PE bilayers assessed by MD simulation and X-ray scattering, Membranes 5:473-494 (2015)

Reese, C.W., Strango, Z.I., Dell, Z.R., Tristram-Nagle, S. , Harper, P.E., Structural insights into the cubic-hexagonal phase transition kinetics of monolein modulated by sucrose solutionsPhysical Chemistry Chemical Physics 17:9194-9204 (2015)

Ma, Y., Ghosh, S.K., Bera, S., Jiang, Z., Tristram-Nagle, S., Lurio, L.B., Sinha, S.K., Accurate calibration and control of relative humidity close to 100% by X-raying a DOPC multilayer, Physical Chemistry Chemical Physics 17:3570-3576 (2015)

Nagle, J.F., Jablin, M.S., Tristram-Nagle, S. ,  Akabori, K., What are the true values of the bending modulus of simple lipid bilayers?  Chemistry and Physics of Lipids 185:3-10 (2015)

Akabori, K., Huang, K., Treece, B.W., Jablin, M.S., Maranville, B., Woll, A., Nagle, J.F., Garcia, A.E., Tristram-Nagle, S., HIV-1 Tat membrane interactions probed using X-ray and neutron scatteringCD spectroscopy and MD simulationsBiochimica et Biophysica Acta 1838:3078-3087 (2014)

Boscia, A., Treece, B.W., Mohammadyani, D., Klein-Seetharaman, J., Braun, A.R., Wassenaar, T.A., Klösgen, B., Tristram-Nagle, S., X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes, Chemistry and Physics of Lipids 178:1-10 (2014)

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ORCID  Researcher ID