Carnegie Mellon University

John F. Nagle

Emeritus Professor

Biological Physics Experiment
Wean Hall 6420

lab website 

Prof. John Nagle

Education & Professional Experience

PhD: Yale University

Professional Societies:
Fellow, American Physical Society
Biophysical Society

Honors and Awards:
Biophysical Society Avanti Award in Lipids (2003)

Research Interests

Prof. John Nagle's research is in the area of biological physics. The particular systems under study are lipid bilayers, which form the structural basis of biomembranes, as well as these systems with additives pertinent to biomembranes. The Nagle group's studies focus on x-ray scattering, as well as theoretical modeling, statistical mechanical calculations and simulations, and volume measurements. The first goal is to obtain reliable data for basic structural properties and their mechanical properties. Another goal is to elucidate the interactions between bilayers. For biologically relevant fluid phase lipid bilayers, these goals involve measuring nanoscale fluctuations, for which they use synchrotron x-rays. A longer-range goal is to understand how the molecular interactions bring about the structure and the fluctuations.

Selected Publications

J. F. Nagle, M. S. Jablin, S. Tristram-Nagle, Sugar does not affect the bending and tilt moduli of simple lipid bilayers, Chem. Phys. Lipids 196, 76 (2016) 

B. Kollmitzer, P. Heftberger, R. Podgornik, J. F. Nagle, G. Pabst, Bending Rigidities and Interdomain Forces in Membranes with Coexisting Lipid DomainsBiophys. J. 108, 2833 (2015)

D. Kopelevich, J. F. Nagle, Correlation between Length and Tilt of Lipid TailsJ. Chem. Phys. 143, 154702 (2015)

J. F. Nagle, K. Akabori, B. W. Treece, S. Tristram‐Nagle, Determination of Mosaicity in Oriented Stacks of Lipid BilayersSoft Matter 12, 1884 (2015)

Kiyotaka Akabori, John F. Nagle, Structure of the DMPC lipid bilayer ripple phaseSoft Matter 11, 918 (2015) 

John F. Nagle, Michael S. Jablin, Stephanie Tristram-Nagle, Kiyotaka Akabori, What are the true values of the bending modulus of simple lipid bilayers?Chemistry and Physics of Lipids 185, 3 (2015) 

M. S. Jablin, K. Akabori, J. F. Nagle, Experimental Support for Tilt-Dependent Theory of Biomembrane MechanicsPhysical Review Letters 113, 248102 (2014)

Joseph C. Albert, Lucas T. Ray, John F. Nagle, Testing procedures for extracting fluctuation spectra from lipid bilayer simulationsJ. Chem. Phys. 141, 64114 (2014) 

Anthony R. Braun, Jonathan N. Sachs, John F. Nagle, Comparing Simulations of Lipid Bilayers to Scattering Data: The GROMOS 43A1-S3 Force FieldThe Journal of Physical Chemistry B 117, 5065 (2013) 

Alexander L. Boscia, Kiyotaka Akabori, Zachary Benamram, Jonathan A. Michel, Michael S. Jablin, Jonathan D. Steckbeck, Ronald C. Montelaro, John F. Nagle, Stephanie Tristram-Nagle, Membrane Structure Correlates to Function of LLP2 on the Cytoplasmic Tail of HIV-1 gp41 ProteinBiophysical Journal 105, 657 (2013) 

John F. Nagle, Introductory Lecture: Basic quantities in model biomembranesFaraday Discussions 161, 11 (2012)

John F. Nagle, Stephanie Tristram-Nagle, Structure of lipid bilayersBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1469, 159 (2000)