Carnegie Mellon University

John F. Nagle

Emeritus Professor

Biological Physics Experiment and Theory
Wean Hall 6420

lab website 

Prof. John Nagle

Education & Professional Experience

PhD: Yale University

Professional Societies:
Fellow, American Physical Society
Biophysical Society

Honors and Awards:
Biophysical Society Avanti Award in Lipids (2003)


Research Interests

Prof. John Nagle's research is in the area of biological physics. The particular systems under study are lipid bilayers, which form the structural basis of biomembranes, as well as these systems with additives pertinent to biomembranes. The Nagle group's studies focus on x-ray scattering, as well as theoretical modeling, statistical mechanical calculations and simulations, and volume measurements. The first goal is to obtain reliable data for basic structural properties and their mechanical properties. Another goal is to elucidate the interactions between bilayers. For biologically relevant fluid phase lipid bilayers, these goals involve measuring nanoscale fluctuations, for which they use synchrotron x-rays. A longer-range goal is to understand how the molecular interactions bring about the structure and the fluctuations.

Selected Publications

John F. Nagle et al., Revisiting Volumes of Lipid Components in BilayersJ. Phys. Chem. B 123, 2697 (2019)

John F. Nagle, Pierre Cognet, Fernando G. Dupuy, and Stephanie Tristram-Nagle, Structure of Gel Phase DPPC Determined by X-ray Diffraction, Chem. Phys. Lipids 218, 168 (2019)

Zoran Arsov, Emilio J. González-Ramírez, Felix M. Goñi, Stephanie Tristram-Nagle and John F. Nagle, Phase behavior of palmitoyl and egg sphingomyelinChem. Phys. Lipids 213, 102 (2018)

John F. Nagle, X-ray scattering reveals molecular tilt is an order parameter for the main phase transition in a model biomembrane, Phys. Rev. E 96, 030401 (2017)

John F. Nagle, Experimentally Determined Tilt and Bending Moduli of Single-Component Lipid Bilayers, Chem. Phys. Lipids 205, 18 (2017)

John F. Nagle, Michael S. Jablin, Stephanie Tristram-Nagle, Sugar does not affect the bending and tilt moduli of simple lipid bilayers, Chem. Phys. Lipids 196, 76 (2016)

J.F. Nagle, K. Akabori, B.W. Treece, S. Tristram‐Nagle, Determination of Mosaicity in Oriented Stacks of Lipid BilayersSoft Matter 12, 1884 (2016)

D. Kopelevich, J.F. Nagle, Correlation between Length and Tilt of Lipid TailsJ. Chem. Phys. 143, 154702 (2015)

Kiyotaka Akabori, John F. Nagle, Structure of the DMPC lipid bilayer ripple phaseSoft Matter 11, 918 (2015)

Michael S. Jablin, Kiyotaka Akabori and John F. Nagle, Experimental Evidence for Tilt-Dependent Theory of Biomembrane Mechanics, Phys. Rev. Lett. 113, 248102 (2014)

John F. Nagle, Introductory Lecture: Basic quantities in model biomembranesFaraday Discussions 161, 11 (2012)

John F. Nagle, Stephanie Tristram-Nagle, Structure of lipid bilayersBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes 1469, 159 (2000)