Gross Mucosal Pathology
During each day in quarantine, participants received an ear, nose, and throat (ENT) exam from a study clinician.
BCS
In the British Cold Study, 6 indicators of gross mucosal pathology were rated by study clinicians:
- Nasal obstruction
- Nasal discharge
- Mucopurulent discharge
- Post-nasal discharge
- Cervical adenitis
- Hoarseness, cough, sputum
Each clinical indicator was rated as being absent, slight, moderate, or severe (See Clinician Daily Observations).
PCS1, PCS2, PMBC, PCS3
In all 3 Pittsburgh Cold Studies and the Pittsburgh Mind-Body Center Study, clinicians rated participants on the 7 specific ENT signs listed in Table 1, and scored them as indicated based on physical examination.
Reference
Alper, C. M., Doyle, W. J., Skoner, D. P., Buchman, C. A., Cohen, S., & Gwaltney, J. M. (1998). Pre-challenge antibodies moderate disease expression in adults experimentally exposed to rhinovirus strain hanks. Clinical Infectious Diseases, 27, 119-128.