Carnegie Mellon University

Michael Domach

Dr. Michael M. Domach

Professor, Chemical Engineering and Biomedical Engineering

Doherty Hall A221
Carnegie Mellon University
5000 Forbes Avenue
Pittsburgh, PA 15213


  • B.S., Chemical Engineering, University of Massachusetts
  • Ph.D., Cornell University, 1983


Professor Mike Domach received his B.S in Chemical Engineering with Environmental Engineering and Chemistry minors from the University of Massachusetts and he obtained his Ph.D. in Chemical Engineering from Cornell University. He was the inaugural Dow Chair Recipient, Universidad Nacional del Sur, Argentina. He has served as a Senior Visiting Scientist, Bioinformatics, The Jackson Lab, Bar Harbor, ME and as a Co-Director of the NIH Training Program in Biotechnology. He is on the Editorial Board of the J. Biotechnology and was a Co-founder Automated Cell Technologies Inc, a NIST-ATP funded company. Prof. Domach wrote the textbook Introduction to Biomedical Engineering, now in its second edition. Currently, he serves as the Editor and Chief of Biotechnology Progress.


Professor Domach studies fundamental and applied aspects of cell engineering and biology. Both experimental and computational work is performed.

Vaccine Production

A collaboration with faculty at the University of Pittsburgh Medical Center and engineers at the University of Pittsburgh aims to develop improved host-plasmid platforms for producing DNA and recombinant protein vaccines.


Cellular Processes

The goal is to understand the behavior of cells in bioreactors and, thus, reactor performance in terms of biochemical reaction and control mechanisms. Current work entails developing in situ NMR and fluorescent spectroscopic methods for observing intracellular reaction processes. Coupling the experimental investigations to mathematical model development also is a key component of this work. The latter entails developing experimental designs that provide high resolution of metabolic fluxes.

Research Interests: high throughput systems for cell growth analysis; optimization of bioreactor performance

Awards and Recognition

  • Appointed Editor of Biotechnology Progress
  • Inaugural Dow Chair Holder, Universidad Nacional del Sur, Argentina, December 2007
  • Dowd Fellowship, Carnegie Institute of Technology, 2001-2002


  • Article won first-place in national competition sponsored by the journal Envir. Progress
  • Fellow, American Institute of Biological and Medical Engineers
  • Recipient of a Presidential Young Investigator Award