Spring 2020
January 15
Karina Mueller Brown
"You’ve got a friend in me (?): The complicated relationship of Streptococcus pneumoniae and Influenza A Virus in host transmission"
January 22
Alexander Hodge
" Direction, does it matter?: Investigating the limits of striatal involvement in reinforcement learning"
January 29
Ian Rosner
"The Importance of Knowing Who You Are Listening To"
February 5
Fiona Fitzgerald
"Under Construction- how the nascent polypeptide exit tunnel is made n’at"
February 19
Rotation Talks
March 4
Christina Akirtava
"Unraveling the roles of 5’ transcripts leaders in gene regulation"
Fall 2019
September 11
Manning Huang
"Circuit Diversification in a Biofilm Regulatory Network"
September 18
Amber Laperuta
"A stem cell lineage contributes to making and remaking of the brain in starfish"
September 25
Teresa Spix
"Opto-Inspired Deep Brain Stimulation for the Treatment of Parkinson's Disease"
October 2
Scott Keith
"The microbiota and synaptic protein Arc1 interact to regulate Drosophila development"
October 9
Iris Yang
"Fantastic FRET pairs and where to find them"
October 16
Alyssa Lawler
"How to talk to cells: Reading and writing the gene regulatory code"
October 23
Bibifatima Kaupbayeva
"Decorating your protein for Halloween... or any day"
October 30
Stephanie Myal
"Wired for experience: how an air puff forms new synapses in whisker sensory cortex"
November 6
Rotation Talks
November 13
Cam LaJeunesse
"The Only Constant is Change: Exploring the Dynamic Nature of Gene Regulatory Networks"
December 4
Dan Crosby
"The Tricky Tale of the Tail"
Spring 2019
January 23
Andrew Wolff
Ph.D. Candidate, Hinman Lab
"Connecting the wound response to whole-body regeneration in sea star larvae"
Tom Fuchs, Ph.D.
Research Associate, Kuhlman Lab
"Sleep deprivation in a nocturnal migrant: Thoughts on comparative sleep research"
February 6
Jimmy Khor
Ph.D. Candidate, Ettensohn Lab
"Analysis of a Model Developmental Gene Regulatory Network"
Rita Bottino, Ph.D.
Adjunct Associate Professor
Institute of Cellular Therapeutics - Allegheny Health Network
"Title TBA"
February 13
Ian Fucci
Ph.D. Candidate, Rule Lab
"Exploring allosteric effects induced by the prodrug AZT in wild-type and mutant human thymidylate kinase"
Nick Giannoukakis
Adjunct Associate Professor
Institute of Cellular Therapeutics - Allegheny Health Network
"Speaking on the paper: Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome"
February 20
Rotation Talks
February 27
Rotation Talks
March 6
David Chen
Ph.D. Candidate, Rule Lab
"Interaction of α-Thymidine Inhibitors and Natural Ligands with Thymidylate Kinase from Plasmodium falciparum"
Javier Lopez, Ph.D.
Associate Professor, Biological Sciences
"Characterizing mutagenic effects of recombination through a sequence-level genetic map." Halldorsson et al (2019) Science 363: eaau1043
March 20
Rolando Cuevas
Ph.D. Candidate, Hiller Lab
"The Streptococcus pneumoniae signaling peptide VP1 influences virulence by controlling bacterial attachment to epithelial cells"
DJ Brasier, Ph.D.
Assistant Teaching Professor, Biological Sciences
"What a pain: circular RNAs and micro RNAs work against each other in the regulation of inflammatory nociception"
March 27
Stephanie Myal
CMU Biologocial Sciences Ph.D. Candidate (3rd year), Barth Lab
"Synaptic traces of behavioral experience in whisker sensory cortex"
Amber LaPeruta
CMU Biologocial Sciences Ph.D. Candidate (4th year), Woolford Lab
"Nobody understands me. Leave me alone! The story of a young ribosome's journey through its unstable adolescence"
April 3
Gregory Logan-Graf, Ph.D.
Postdoc, McCartney Lab
"Spatiotemporal Regulation of Actin Cable Growth in Drosophila Nurse Cells"
April 17
Kaustubh Sinha, Ph.D.
Assistant Research Professor
"Thymidylate Kinase from Candida albicans: a promising new target for drug development"
Katrina Nguyen
Ph.D. Candidate, Biomedical Engineering
"Mice modulate paw kinematics when learning a novel locomotor task"
April 24
Iris Yang
Ph.D. Candidate, Bruchez Lab
"FRET-based biosensors with FAP-based FRET pairs"
Melanie Gainey, Ph.D. & Huajin Wang, Ph.D.
Library Liaison to Biological Sciences
"Data Management and Collaboration Services from CMU Libraries"
May 1
Rotation Talks
May 8
Rotation Talks
Fall 2018
September 12
Alyssa Lawler, CMU Biologocial Sciences Ph.D. Candidate (3rd year), Pfenning Lab
Talk title: Epigenetically informed technologies for improved cell type-specific labeling in vivo
September 19
Ashley Leslie, CMU Biologocial Sciences Ph.D. Candidate (3rd year), McCartney Lab
Title: The +TIPs EB1 and CLIP spatiotemporally regulate actin cable assembly during Drosophila oogenesis
Bibifatima Kaupbayeva, CMU Biologocial Sciences Ph.D. Candidate (3rd year), Russell Lab (DHTI)
Title: Intramolecular sieving on the surface of a nano-armored protein
October 3
Christopher Post, MD, Ph.D.
Director of Allegheny Pediatric ENT Associates, Allegheny General Hospital
"Biofilms in Human Health"
October 10
Jonathan Jarvik, Ph.D.
Associate Professor, CMU Biological Sciences
"A tale of three giants"
October 17
Scott Keith
CMU Biologocial Sciences Ph.D. Candidate (4th year), McCartney Lab
"The microbiota and synaptic protein Arc1 interact to regulate Drosophila development"
John Woolford, Ph.D.
Professor, CMU Biological Sciences
"Toggling between mRNA isoforms to integrate transcriptional and translational regulation... an emerging paradigm for developmental pathways?"
October 24
Stephanie Tristram-Nagle, Ph.D.
Research Professor, CMU Biological Physics Group, Physics
"Use of diffuse X-ray scattering to determine both elastic constants and structure of peptide/lipid interactions"
Yong Fan, Ph.D.
Adjunct Associate Professor, Institute of Cellular Therapeutics - Allegheny Health Network
"Exosomal PD-L1 contributes to immunosuppression in cancer patients"
October 31
Daniel Wilson
CMU Biologocial Sciences Ph.D. Candidate (4th year), Woolford Lab
"If you want to build a tunnel, you have to fold RNA"
Tzahi Cohen-Karni, Ph.D.
Assistant Professor, CMU Department of Engineering and Materials Science & Engineering
"Bioelectronics with graphene and graphene-based hybrid-nanomaterials – from transparent to fuzzy interfaces"
November 7
Rotation Talks
November 14
Rotation Talks
November 28
Nathaniel Williams
CMU Biological Sciences Ph.D. Candidate, Olson Lab
"Spatial generalization of repetition suppression in macaque visual cortex"
Eric Yttri, Ph.D.
Assistant Professor, CMU Biological Sciences
"How you know that you’re right"
Paper: Confirmation Bias through Selective Overweighting of Choice-Consistent Evidence Talluri et al., Current Biology, 2018
December 5
Brian Jeon
Kuhlman Lab
"Brain-computer interface training increases the dynamic range of individual neurons within an ensemble"
Katherine Buckley
Hinman & Ettensohn Labs
"Evolution of immune response: lessons from an echinoderm"
December 12
Dan Ackerman
CMU Biological Sciences Ph.D. Student, Jarvik Lab
"TEFLA and TAPS: expanding the fluorogen toolkit"
Spring 2018
January 31
Ian Fucci
"-OH, What a difference it makes"
Nat Williams
"Responses of Neurons in Macaque Inferotemporal Cortex to Repeated Images"
February 7
Minyan Zheng
"A stem cell lineage contributes to making and remaking of the brain in starfish"
Gordon Rule
"Proteins on the edge – what does it take to push them over?"
February 14
Nick Audette
"Thalamocortical plasticity driven by sensory experience"
William Hatleberg (Hinman Lab)
"Genomic insight into the evolution of larval body plans"
February 21
Rotation Talks
February 28
David Chen
"Interaction of α-Thymidine Inhibitors with Thymidylate Kinase from Plasmodium falciparum"
March 7
Yizhu Lin
"Causal discovery in post-transcriptional mRNA dynamics"
Charles Ettensohn
"Positioning planes of cell division in the early embryo"
March 21
Victoria Corbitt
"Circuit-specific corticostriatal dysfunction in an OCD mouse model"
Yong Fan
"In Vivo Target Gene Activation via CRISPR/Cas9- Mediated Trans-epigenetic Modulation"
March 28
Brendan Redler
"Improving Proteomics by Improving Proteomes: Advances in sample preparation for cleaner, faster proteomics"
David Hackney
"Using cold to see inside a membrane"
April 4
Rita Bottino
Discussing the article "Insulin resistance in cavefish as an adaptation to a nutrient-limited environment". Nature. 2018; Mar 29;555(7698):647-651
Bistra Iordanova
University of Pittsburgh
"Left-right brain connectivity - how cells drive MRI functional signals"
April 11
Amber Lucas
"Protein changes in the Drosophila brain upon Wolbachia infection"
Dika Kuljis (Barth Lab)
Discussing the paper: "Thalamic inhibition regulates critical-period plasticity in visual cortex and thalamus" by Jean-Pierre Sommeijer et al., Nature Neurosci, 2017
April 18
Pati Stan
"Beyond edge detection: the role of V1 feature selectivity in processing visual scenes"
Kate Buckley (Hinman Lab)
"Tiny, swimming guts at sea: Using sea urchin larvae as a simple system to understand gut immunity"
April 25
Stephanie Biedka
"Hierarchical recruitment of ribosomal proteins and assembly factors remodels nucleolar pre-60S ribosomes"
May 2
Emily Simon
"Role of Mucin-type O-Glycosylation on the Ebola Virus Glycoprotein for Loss of Cell Adhesion"
Christopher Szent-Gyorgyi
"Secrete, Capture, Sort, Sequence: NGS Decoded Molecular Recognition Pairs"
May 9
Rotation Talks
Fall 2017
September 13
Daniel Wilson
"A tail of three ribosome assembly factors: redundant functions in construction of the polypeptide exit tunnel"
Brett Phillips (Cellular Therapeutics)
"Alzheimer's Disease and Insulin Resistance"
September 20
Iris Yang
"FRET-based biosensors with FAP-based FRET pairs"
Aryn Gittis
"Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons"
September 27
Manning Huang
"CRISPR-based Toolbox to Explore Natural Variation in Candida albicans"
John Woolford
"A New Frontier in Gene Regulation: Are There Specialized Ribosomes Dedicated to the Translation of Specific mRNAs? "
October 4
Amber LaPeruta
"The construction of the peptidyl transferase center in the 60S ribosomal subunit requires the GTPase activity of the assembly factor Nog1"
Eric Yttri
"A hormone-related female anti-aphrodisiac signals temporary infertility and causes sexual abstinence to synchronize parental care"
October 11
Scott Keith
"Investigating the molecular basis of host-microbe symbiosis in Drosophila melanogaster"
Sandra Kuhlman
"A Timely Discussion of Circadian Clocks"
October 18
Dan Ackerman
"Inflammation o’clock: AAVs and MNAs in real-time biosensor development"
Chien Ho
"An Example of Translating Laboratory Findings to Clinical Applications"
October 25
Surya Aggarwal
"Signals to Kill & Signals to Die: Just Another Day in the Pneumococcal Life"
Jacob West-Roberts
"Cheese Wars: Revenge of the Swiss"
November 1
Jimmy Khor
"Linking gene regulatory networks to morphogenesis"
DJ Brasier
"Beyond the immune system: how your skin remembers"
November 8
Rotation Talks
December 6
Andrew Wolff
"Identifying conservation of metazoan features of regeneration in a larval echinoderm"
Joel McManus
"Bacterial translation gets a structured settlement"
December 13
Amanda Willard
"Progression of SNr pathophysiology in mouse models of Parkinson's Disease"
Brian Jeon
"Stability of orientation and spatial frequency preference in visual cortex of mouse"
Spring 2017
January 18
Minyan Zheng
"Regenerating the sea star brain"
Claire Cheetham
"The hunted becomes the hunter: brain circuits for predatory behavior"
February 1
Nick Audette
"Thalamo-cortical circuit rearrangements after sensory association training"
Rita Bottino
"A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin"
February 8
Vinitha Ganesan
"Discovering biomarkers for Rheumatoid Arthritis associated Interstitial lung disease"
Yong Fan
"How much to drink from the Fountain of the Youth - reversal of aging with Yamanaka factors?"
February 15
Berquin Feese
"Rapid adaptability of L2/3 PV inhibitory neurons in mouse primary visual cortex"
Emily Simon
"How does the Ebola virus glycoprotein cause hemorrhage?"
February 1
Rotation Reports
3:30- 3:40: Ashley Leslie - "Using LOVTrap to Investigate the Role of EB1 in Actin Cable Assembly"
3:40- 3:50: Tyler Nelson - "Uncovering the Role of Newborn Olfactory Sensory Neurons with in-vivo Calcium Imaging"
3:50- 4:00 Stephanie Myal - "Cholinergic Modulation of Sensory Cortical Microcircuits"
4:00- 4:10 Alyssa Lawler - "When all else changes: Orthologous gene targets of transcription factor Tbrain in Echinoderms" \
4:10- 4:20: Jennifer Kunselman - "C-terminal Tail of Atlastin: Role in Membrane Fusion"
4:20- 4:30: Bibifatima Kaupbayeva - "Universal method for proteome purification"
March 1
Salini Konikkat
"Seq'ing RNA Ends: Towards Understanding Transcript Diversity and Regulation Mechanisms"
Tina Lee
"Designed proteins induce formation of nano cage-containing extracellular vesicles" (Nature Dec 2016, 540:292-295.)
March 8
Yizhu Lin
"Structural analyses of NEAT1 lncRNAs suggest long-range RNA interactions contribute to paraspeckle architecture"
DJ Brasier
"ApoE and the cell biology of Alzheimer's disease"
March 22
Victoria Corbit
"Dissecting corticostriatal microcircuits involved with compulsive-like grooming in a Sapap3-KO OCD mouse model"
Kevin Mastro
"Title TBA"
March 15
Brendan Redler
"Title TBA"
Russell Schwartz
"Going Out with a Bang: A Big Bang Model of Colorectal Tumor Growth"
April 5
Malachi Blundon
"The impact of microbiota on brain and alcohol responses"
David Hackney
"Going with the flow - microtubules and motors alone can drive directed fluid flow"
April 12
Anagha Kadam
"Promiscuous Signaling by a Regulatory System Unique to the Pandemic PMEN1 Pneumococcal Lineage"
April 19
Ceren Tuzmen
"A very important peptide: VIP as a modulator of bone repair during inflammation"
Andreas Pfenning
"A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication"
April 26
Greg Cary
"Labile transitions between attractor kernels in developmental regulatory network evolution"
Kristin Quick
"The problem of reciprocally connected networks: How to prevent runaway activity"
May 3
Swati Venkat
"Sorting of oligomerized proteins: Implications in Shiga toxin trafficking and quality control"
Amanda Willard
"Time-course of basal ganglia network changes in Parkinson's Disease using a gradual dopamine depletion paradigm"
May 10
Rotation Reports
May 17
Brian Jeon
"Stability of orientation and spatial frequency tuning in mouse primary visual cortex"
Pati Stan
"Beyond Edge Detection: The Role of Neurons in the Primary Visual Cortex"
Fall 2016
August 31
Dan Ackerman
"The Biotattoo: Developing Novel Technologies for Inflammation Monitoring"
Alison Barth
"Experimental data and machine learning: lessons from the NeuroHackathon"
September 7
Surya Aggarwal
"Molecular Mechanisms Linking Penicillin Resistance and Virulence Determinants in Pneumococcus"
Sandra Kuhlman
"Building a circuit for plasticity and learning, what can go wrong?"
September 14
Stephanie Biedka
"Ribosomal protein L19 is required for remodeling events preceding 27SB pre-rRNA processing"
Jon Jarvik
"Wouldn't it be nice"
September 21
David Chen
"Development of Novel PfTMK Inhibitors as Anti-Malarial Agents
Chien Ho
"A New Method for Preparing Mesenchymal Stem Cells for Biomedical & Clinical Applications"
September 28
Rolando Cuevas
"The novel protein VP1 is required for virulence in Streptococcus pneumoniae"
Nick Giannoukakis
"Gut microbiota translocation to the pancreatic lymph nodes trigger NOD2 activation and contributes to T1D onset"
October 5
Ian Fucci
"Structural Characterization of Protein-Polymer Conjugates by NMR Spectroscopy"
Fred Lanni
"Yeast make bad decisions, too!"
October 5
Amber Lucas
"Development and Commercialization of a Universal Proteome Purification Method"
Joel McManus
"Coming to “terms” with antibiotic resistant bacteria"
October 12
Stephanie Biedka
"Ribosomal protein L19 is required for remodeling events preceding 27SB pre-rRNA processing"
Jon Jarvik
"Wouldn't it be nice"
October 19
Jimmy Khor
"Dissecting GRN Architecture: an Analysis of Alx1, a Key Regulatory Gene in the Sea Urchin Skeletogenic GRN"
Andrew Wolff
"A shift from normal to regeneration-specific proliferation in the sea star Patiria miniata"
October 26
Alan Shteyman
"Guess Who?: The Serious Subject of Inferring Missing Values"
Charles Ettensohn
"Transforming somatic cells into gametes: Complete in vitro reconstitution of the mouse female germ line"
November 2
Elena Shuvaeva
"Regulation of β2-adrenergic receptor post-endocytic trafficking"
Aryn Gittis
"Central Control Circuit for Context-Dependent Micturition"
November 9
Rotation Reports
(3:30) Fatima Kaupbayeva - "Universal method for proteome purification"
(3:40) Jennifer Kunselman - "Homeostatic Regulation of Mu-Opioid Receptor Recycling"
(3:50) Alyssa Lawler - "Somatostatin-Expressing Interneurons: Implications in Schizophrenia"
(4:00) Ashley Leslie - "At Last! An Acute Method to Evaluate the Role of Atlastin in ER Dynamics"
(4:10) Stephanie Myal - "Title TBA"
(4:20) Tyler Nelson - "The Role of Motor Cortex in Long-Term Motor Recovery In a
Mouse Model of Parkinson's Disease"
(4:30) HAPPY HOUR
November 16
Brooke McCartney
"The complexities of cancer: how restoration of a single tumor suppressor can turn back the clock on progression"
November 30
Nathaniel Williams
"Repetition Suppression in Macaque Inferotemporal Cortex"
Veronica Hinman
"Coming onto Land: The Fin to Limb transition"
Spring 2016
Date |
Speaker |
Topic |
|
| 1/13 | Brendan Redler | TBA | |
| Kevin Mastro (Pitt) | Cell-specific pallidal stimulation produces long-lasting recovery of movement in a mouse model of PD | ||
| 1/20 | Lina Song | No More Sugar: Identification and Characterization of a Novel Isoform-Specific GalNAc Transferase Inhibitor | |
| Nick Giannoukakis |
Speaking on "Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis" Levine YA, Koopman FA, Faltys M, Caravaca A, Bendele A, Zitnik R, Vervoordeldonk MJ, Tak PP. Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis. PLoS One. 2014 Aug 11;9(8):e104530. |
||
| 1/27 | Ceren Tuzmen | Heterotopic ossification has some nerve: Crosstalk between sensory neuropeptides and BMP-2 signaling in tendon | |
| David Hackney | How to Build a Superhelicase | ||
| 2/3 | Swati Venkat | Sorting of oligomerized proteins: Implications in Shiga toxin trafficking and quality control | |
| Rita Bottino | |||
| 2/10 | Amanda Willard | Time-course of basal ganglia network changes in Parkinson's Disease using a gradual dopamine depletion paradigm | |
| 2/17 | Shawn Burton | Molecular identification of a novel GABAergic circuit in the olfactory bulb | |
| Joel McManus |
TRAP-ping the translatome of developing Drosophila photoreceptor neurons Zhang KX, Tan L, Pellegrini M, Zipursky SL, McEwen JM. Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals. Cell Rep. 2016 Feb 9;14(5):1258-71 |
||
| 2/24 | Rotation Reports (3:30) Iris Yang - "Codon Bias and uORF Function" (3:40) Daniel Wilson - "Developing a Model for Targeted Photoablation of Tumors" (3:50) Teresa Spix - "Know your gnotobiotics: A tool for investigating the microbiota" (4:00) Amber Laperuta - TBA (4:10) Scott Keith - "Mapping the Drosophila Gut Microbiota via Fluorescence in situ Hybridization" (4:20) Manning Huang - "Putative Export Signals in Streptococcus pneumoniae" (4:30) Stephanie Crilly - "Investigating atlastin dimerization kinetics" |
||
| 3/2 | Natalie McGuier | Learning-induced plasticity in visual cortex: A project proposal | |
| Javier Lopez |
Cold Play: Searching for missing human heritability with small sample Fumagalli et al. Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science 349:1343 Sept 18 2015. |
||
| 3/9 | Spring Break |
||
| 3/16 | Beril Tutuncuoglu | Late Nuclear Stages of 60S Ribosomal Subunit Assembly Involve Multiple Conformational Changes in Two Distinct Neighborhoods | |
| Brian Jeon | Investigating Properties of Neural Circuits via Ca++ Imaging Based Brain Computer Interface in Mice | ||
| Yessica Garcia Figueroa | |||
| 3/30 |
Christopher Pratt |
||
| Stacie Oliver | The Wnt signaling and cytoskeletal regulator APC2 controls stem cell niche size and architecture | ||
| 4/6 | Tanvi Shashikant | The Genomic Control of Skeletal Morphogenesis in the Sea Urchin Embryo | |
| Alan Waggoner | Neural activity monitoring/mapping in brain | ||
| 4/13 | Dan Shiwarski | A Golgi export checkpoint limits the efficacy of delta opioid receptor agonists in sensory neurons | |
| Huajin Wang | How Do Lipid Droplets Form and Grow? - Implications From The Lipodystrophy Gene BSCL2/Seipin | ||
| 4/20 | Brett Benedetti | ||
| 4/27 | Rotation Reports | ||
| 5/4 |
Philip Davidson |
The Kinase Awakens: Investigating the Kinases of the Sporulation Initiation Pathway | |
| 5/11 | Michael Passineau | Salivary Gland Gene Therapy: Clinical Impact and Post-Trial Optimization | |
|
Pieter Spealman |
Comparative translatomics reveal a conserved class of noncanonical uORFs in yeast | ||
Fall 2015
|
Date |
Speaker |
Topic |
|
|
9/2 |
Katie Lagree |
Regulation of Candida albicans adherence and biofilm formation |
|
|
Manoj Puthenveedu |
The brain on the clock - a structural correlate to circadian rhythms |
||
|
9/9 |
Dylan McCreary |
Experience Dependent Changes in mini EPSC Frequency in Sensory Neocortex Validate Hypotheses Driven by High Throughput Electron Microscopy |
|
|
Aryn Gittis |
|
||
|
9/16 |
Lydia Perkins |
Discovery of New Gene Targets for Synergistic Cystic Fibrosis Therapies |
|
|
Veronica Hinman |
Tracing our Origins: Who was Homo naledi
Berger LR, et al. Homo naledi, a new species of the genus Homo from the Dinaledi Chamber, South Africa. Elife. 2015 Sep 10;4. |
||
|
9/23 |
Emily Simon |
Regulation of the Dynein Adaptor Golgin-160 for Golgi Membrane Transport |
|
|
Sandra Kuhlman |
On the fly: How opposing signals can create a coherent representation
Mauss AS, Pankova K, Arenz A, Nern A, Rubin GM, Borst A. Neural Circuit to Integrate Opposing Motions in the Visual Field. Cell. 2015 Jul 16;162(2):351-62. |
||
|
9/30 |
Zach Weinberg |
Controlling Signaling Through Controlling Trafficking |
|
|
Claire Cheetham |
The power of positive thinking: can happy memories prevent depression?
Ramirez S, Liu X, MacDonald CJ, Moffa A, Zhou J, Redondo RL, Tonegawa S. Activating positive memory engrams suppresses depression-like behaviour. Nature. 2015 Jun 18;522(7556):335-9. |
||
|
10/7 |
James Winsor |
Probing the atlastin fusion mechanism using fluorescence |
|
|
Fred Lanni |
Membrane signal transduction mechanisms |
||
|
10/14 |
Minyan Zheng |
Examination of gene expression changes during larval regeneration in starfish P.miniata |
|
|
John Woolford |
Using yeast and flies to explore yet another pathway dysfunctional in neurodegenerative disorders (FTD/ALS) |
||
|
10/21 |
Malachi Blundon |
To put “Apep” in APC’s step: Using proteomics to build molecular pathways |
|
|
Kenneth Miller (Ph.D. ’95) Biological Sciences Alumnus Speaker Senior Scientist, MedImmune |
Analytical Characterization of Biopharmaceuticals for First-Time In Human (FTiH) Clinical Trials |
||
|
10/28 |
Nick Audette |
Sensory input engages different circuit structures in deep and superficial layers of the cortex |
|
|
Marcel Bruchez |
Snap, Crack or Pop: Mechanics of S. Aureus Division |
||
|
11/4 |
Vinitha Ganesan |
Discovery prognosis biomarkers to predict lung disease in Rheumatoid Arthritis |
|
|
Victoria Corbit (Pitt) |
Novel interneuron-selective pallidostriatal projection is crucial for pathological beta oscillations in a computational model |
||
|
11/11 |
Berquin Feese |
The Role of ErbB4 in Proper Development of Inhibitory Neurons |
|
|
Adam Linstedt |
Touchy Feely Mechanotransduction |
||
|
11/18 |
Rotation Reports Stephanie Crilly - "Anatomical changes in basal ganglia circuitry in response to dopamine depletion" Manning Huang - "Characterizing Ywp1, an anti-adhesin that regulates biofilm formation in Candida albicans" Scott Keith - "Investigating a Potential Family of Exported Peptides in Streptococcus pneumoniae" Amber LaPeruta - "What's my purpose? Exploring the function of rRNA m3U modifications" Teresa Spix - "To move or not to move: Behavioral effects of external pallidal stimulation" Daniel Wilson - Title TBA Iris Yang - Title TBA |
||
|
11/25 |
Thanksgiving Break |
||
|
12/2 |
Yong Fan |
Mitigating oxygen shock to enhance hematopoietic stem cell engraftment |
|
|
Kevin Zitelli (Pitt) |
|
||
|
12/9 |
Yizhu Lin |
Evolutionary comparison of yeast mRNA secondary structure by high-throughput sequencing |
|
|
Jon Jarvik |
Drug-Target Network |
||
Spring 2015
|
Date |
Speaker |
Topic |
|
|
1/21 |
Tanvi Shashikant |
From Genome to Morphology: The Dissection of a Developmental Gene Regulatory Network |
|
|
Zhongling Sun |
Regulation of Skeletal Morphogenesis by TGF-β Signaling in the Sea Urchin Embryo |
||
|
1/28 |
Daniel Shiwarski |
Unlocking the DOR to the surface: Regulated Surface Delivery of the δ-Opioid Receptor (DOR) |
|
|
David Hackney |
Enzymes on the move in ways you probably did not expect |
||
|
2/4 |
Ardon Shorr |
How does gravity affect gene expression? A proteomic approach |
|
|
Chien Ho |
Accidental Discovery in Research |
||
|
2/11 |
Pieter Spealman |
N-terminal extensions: Protein Isoforms Revealed Under Stress |
|
|
Maureen Stolzer |
Evolution of the Metazoan Protein Toolkit |
||
|
2/18 |
Shanna Bowersox |
A Drug Selective Phosphoswitch Regulates mu-Opioid Receptor Recycling |
|
|
John Woolford |
A novel mechanism for translational control in mammalian development....specialized ribosomes?
Xue S, Tian S, Fujii K, Kladwang W, Das R, Barna M. RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation. Nature. 2015 Jan 1;517(7532):33-8. |
||
|
2/25 |
Christopher Pratt |
Red Light, Green Light: Two-Color Fluorogen Labeling Unveils BK Channel Trafficking |
|
|
Brooke McCartney |
Making connections: how "interactomics" teaches us about the inner lives of cells
Nicolas Preitner, Jie Quan, Dan W. Nowakowski, Melissa L. Hancock, Jianhua Shi, Joseph Tcherkezian, Tracy L. Young-Pearse, John G. Flanagan. APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly. Cell, Volume 158, Issue 2, 17 July 2014, Pages 368-382. |
||
|
3/4 |
Rotation Talks
Dan Ackerman - “Colocalization of β2AR with TGN46, a Marker for the Trans-Golgi Network”
Amber Lucas - "Proteome sample cleanup using biotinylated proteins and polymer caged Avidin"
Surya Aggarwal - "Streptococcus pneumoniae Penicillin Resistance: Genotypes, Phenotypes & Fitness Costs"
Stephanie Biedka - "The Role of Ribosomal Proteins in 5S rRNA Rotation”
David Chen - "Effects of NGF Treatment on Delta-Opioid Receptor – Rab2/6 Interaction"
Hannah Kim - "A Journey to Find Phenotypes Associated to Gene Knockouts in Streptococcus pneumoniae"
Ian Fucci - “Probing dynamics of mutant and wild-type human thymidylate kinase using NMR spectroscopy”
Jian Ming Khor - "Targeting of Dishevelled in Early Embryogenesis"
Rolando Cuevas - "The CORVET Subunit VPS8 regulates recycling of β2 Adrenergic Receptor"
Alan Shteyman - “To Impute or Not To Impute: That is my Rotation Question”
Elena Shuvaeva - "The role of ribosomal protein L28 in late stage large subunit assembly"
Meiqi Wang - "Image-derived generative models of cellular organization"
Nathaniel Williams - "Defining subnetworks within the mouse visual system"
Andrew Wolff - "Atlastin disease mutation alters mitochondrial distribution" |
||
|
3/11 |
Spring Break |
||
|
3/18 |
Karen Kormuth |
A Novel Mode of Homologous PNA Hybridization to G-quadruplex DNA |
|
|
Marcel Bruchez |
Long Ago and Far Away: Presynaptic Activity Regulates Gene Expression at the Soma
Daniela Ivanova, Anika Dirks, Carolina Montenegro-Venegas, Cornelia Schöne, Wilko D Altrock, Claudia Marini, Renato Frischknecht, Denny Schanze, Martin Zenker, Eckart D Gundelfinger & Anna Fejtova. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. The Embo Journal, 4 Feb 2015. |
||
|
3/25 |
Han Lai |
An Eye Catching Tale: How Gene Transfer Allows Colonization of a New Niche |
|
|
Jonathan Jarvik |
Aging and surviving in the tree of life |
||
|
4/1 |
Ting Liu |
Polymorphism of DNA ejection dynamics - not every virion is ready to infect |
|
|
Marcel Bruchez |
Long Ago and Far Away: Presynaptic Activity Regulates Gene Expression at the Soma
Daniela Ivanova, Anika Dirks, Carolina Montenegro-Venegas, Cornelia Schöne, Wilko D Altrock, Claudia Marini, Renato Frischknecht, Denny Schanze, Martin Zenker, Eckart D Gundelfinger & Anna Fejtova. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. The Embo Journal, 4 Feb 2015. |
||
|
4/8 |
Salini Konikkat |
New Alleles Reveal Later Functions of Erb1 in Ribosome Assembly |
|
|
Chuck Ettensohn |
Regeneration of digits in mice and humans |
||
|
4/15 |
John Pettersson |
Single Molecule Studies of Glutathione S-Transferase |
|
|
Luisa Hiller |
The Invisible World: A Source of New Chemistry to Target Superbugs |
||
|
4/22 |
Sahil Sangani |
Dynamics of a Protein-DNA-Metal Complex |
|
|
Russell Schwartz |
Do You Feel Lucky? |
||
|
4/29 |
Madhumitha Ramesh |
Novel Roles for Eukaryote-Specific rRNA Expansion Segments in Ribosome Biogenesis |
|
|
Tina Lee |
Myoblasts perform under pressure
Kim JH, Ren Y, Ng WP, Li S, Son S, Kee, YS, Zhang S, Zhang G, Fletcher DA, Robinson DN and Chen E. Mechanical Tension Drives Cell Membrane Fusion. |
||
|
5/6 |
Rotation Talks
Dan Ackerman - “Activity of the ER at sites of endosome tubule fission”
Surya Aggarwal - "Why double you P1 inhibits biofilm formation"
Stephanie Biedka - "The C-terminus of ATL1 inhibits ATL1 GTPase activity in vitro”
David Chen - "Improving Cell Permeability of (R)-Diethylene Glycol-Contacting γ-PNA"
Rolando Cuevas - "Assessing Dishevelled Self-Association During Early Embryogenesis of Lytechinus variegatus"
Hannah Kim - TBA
Ian Fucci - “The Nucleotide-Free Refractory State of Kinesin Motor Domains may be a Molten Globule”
Jian Ming Khor - "The Role of Lunapark in Endoplasmic Reticulum Structuring"
Amber Lucas - "Proteomic analysis of early regeneration in Patiria miniata"
Alan Shteyman - “I think I've seen this Pattern before”
Elena Shuvaeva - "Regulation of β2-adrenergic receptor recycling and resensitization"
Meiqi Wang - "In vivo detection of FAP expression in neurons"
Nathaniel Williams - "Exploring the Effect of Familiarity in the Visual System"
Andrew Wolff - "Characterization of cell proliferation during sea star regeneration" |
||
|
5/13 |
Massimo Trucco |
Institute of Cellular Therapeutics at Allegheny General Hospital |
|
|
Nick Giannoukakis |
Institute of Cellular Therapeutics at Allegheny General Hospital |
||
Fall 2014
|
Date |
Speaker |
Topic |
|
|
9/3 |
A. Javier López |
Woof! Genomics and evolution of our best friend |
|
|
Nicholas Audette |
An Evolving View of the Barrel Cortex Circuit |
||
|
9/10 |
Manoj Puthenveedu |
Why Pittsburgh Winters are Depressing
Fell GL, Robinson KC, Mao J, Woolf CJ, Fisher DE. Skin β-endorphin mediates addiction to UV light. Cell. 2014 Jun 19;157(7):1527-34. |
|
|
Berquin Feese |
The Role of ErbB4 in Developmental Adaptation in the Primary Visual Cortex |
||
|
9/17 |
Frederick Lanni |
Cells on the lam(ellipod) |
|
|
Malachi Blundon |
Identifying acute APC-dependent proteome changes in Drosophila melanogaster |
||
|
9/24 |
Sandra J. Kuhlman |
Closing the loop: brain-computer interfaces for mice
Clancy KB, Koralek AC, Costa RM, Feldman DE, Carmena JM. Volitional modulation of optically recorded calcium signals during neuroprosthetic learning. Nat Neurosci. 2014 Jun;17(6):807-9. |
|
|
Vinitha Ganesan |
Proteomic tool for discovering autoantigens |
||
|
10/1 |
Anagha Kadam |
Characterization of a Novel Genomic Locus in a Pandemic Pneumococcus Lineage |
|
|
|
|||
|
10/8 |
Philip Davidson |
Tracking the evolution of the sporulation initiation pathway |
|
|
Yizhu Lin |
High-throughput probing of human sno-lncRNA secondary structure |
||
|
10/15 |
Adam D. Linstedt |
Flipping & scrambling to be eaten |
|
|
Brendan Redler |
Mapping required residues for retrograde trafficking of AB5 toxins |
||
|
10/22 |
Dr. Hayder Ali Samaka, Visiting Scientist |
Regulators of Candida Drug Responses during Infection |
|
|
Aaron Karako, Associate Program Manager - CRDF Global |
International Research Partnerships |
||
|
Lina Song |
Divide and Conquer: From Pan- to Isoform-Specific Sensor for GalNAc Transferases |
||
|
10/29 |
Stacie Oliver |
The Wnt signaling and cytoskeletal regulator APC2 controls stem cell niche size and architecture |
|
|
Ceren Tuzmen |
Nerves and BOOnes: Neuronal and Musculoskeletal Connections in Heterotopic Ossification |
||
|
11/5 |
Beril Kumcuoglu |
Ribosomal Protein Mediated Conformational Changes during 60S Subunit Assembly |
|
|
Amanda Willard |
A novel 6-OHDA dopamine depletion paradigm |
||
|
11/12 |
Joel McManus |
Destined to translate: coupling transcriptional and translational responses to glucose starvation
Zid BM, O'Shea EK. Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast. Nature 514; 117-121 (02 October 2014). |
|
|
Shawn Burton |
Inhibition of inhibition in olfaction. Part I: Patterning the olfactory bulb outputs |
|
|
|
12/3 |
Veronica F. Hinman |
The single cell and whole-organism science |
|
|
Swati Venkat |
Understanding the molecular mechanisms underlying Shiga toxin-receptor interaction |
||
|
12/12 *1:30 pm - 5 pm |
Rotation Talks Dan Ackerman - “Assembly of 5S rRNA into Pre-ribosomes”
Amber Lucas - “Assembly of 5S rRNA into Pre-ribosomes”
Surya Aggarwal - "Effects of NGF Treatment & PI3K inhibition on Rab2 localization"
Stephanie Biedka - "Molecular mechanisms of cellular reprogramming in the sea urchin embryo”
Mengshen Chen - "Characterization of Kinesin State Transition"
Hannah Kim - “Buffering between transcription and translation in yeast”
Ian Fucci - Transcriptome-wide mRNA structure probing in two species of yeast
Jian Ming Khor - “Evolution of novelty: co-option of the sea star skeletogenic gene regulatory network into a new spatial-temporal context”
Rolando Cuevas - “Elucidating the mechanism involved in Golgi Positioning”
Alan Shteyman - “Analyzing Cancer Phylogenetics Trees Using Consensus Trees”
Elena Shuvaeva - “A Wolf in SHB's Clothing: Investigation of C. albicans genes"
Meiqi Wang - “Visual acuity test using calcium imaging”
Nathaniel Williams - "Investigating the Role of VPS8 in Sequence Dependent Recycling"
Andrew Wolff - "Using Imaging to Identify Specific Brain Regions" |
||
|
|
|||
Spring 2014
|
Date |
Speaker |
Topic |
|
1/15 |
Ardon Shorr |
Gravity |
|
Matt Saunders |
Applications of Fluorogen Activating Proteins (FAPs) in Molecular Biology or FAPlications |
|
|
1/22 |
Pieter Spealman |
Starvation is Not a Piece of Cake |
|
Alison Barth |
The Language-related Transcription Factor FoxP2 Regulates Synaptic Density and Vocalization in Mice |
|
|
2/5 |
Shanna Bowersox |
Cell Autonomous Tuning of Opioid Responses by Substance P |
|
Chien Ho |
An Old Drug With New Tricks |
|
|
2/12 |
Rotation 2 Presentations |
|
|
2/19 |
Gino Gallo |
Biosensor Romance: Match-Making and Love at a Molecular Level |
|
Veronica Hinman |
Cerebrating Darwin Day: On the Inheritance of Acquired Characteristics |
|
|
2/26 |
Salini Konikkat |
Dissecting Molecular Interaction Networks in Ribosome Assembly |
|
David Hackney |
Deep Fried Crystallography |
|
|
3/5 |
Karen Kormuth |
Unconventional Guanine Quadruplexes and their Role in Ribosome Biosynthesis |
|
Xiaohong Tan |
A 95% off sale for molecular beacon *with a coupon of label-free |
|
|
3/12 |
No Journal Club Due to Spring Break |
|
|
3/19 |
Han Lai |
What makes a Prochlorococcus a Prochlorococcus? A genome content analysis |
|
Wenjie Xu |
Pathogen gene expression during infection |
|
|
3/26 |
Ting Liu |
Pump DNA into Viral Capsid Shell |
|
Tina Lee |
The Cost of Moving a Lipid = Moving Another Lipid |
|
|
4/2 |
Kaustubh Sinha |
Mapping Metal Ion Effects in a Protein-DNA Complex |
|
4/9 |
John Pettersson |
The Secret Life of GST: Enzyme Characterization in Singulo |
|
Robert Murphy |
Learning Protein Function From Noise |
|
|
4/16 |
Madhumitha Ramesh |
Intriguing Exceptions: Roles of rRNA Expansion Segments in Ribosome Biogenesis |
|
Olivia Molinar |
Walking the walk, talking the talk: APC proteins speak the language of actin assembly factors in vivo |
|
|
4/23 |
Sahil Sangani |
Studying Metal-ion Effects in a Protein-DNA Complex |
|
Russell Schwartz |
Death is a journey, not a destination: unraveling mutation processes in cancer development and progression |
|
|
4/30 |
ROTATION 3 PRESENTATIONS Katie Lagree “Trafficking Dynamics of the A118G SNP in the μ-opioid Receptor” Dylan McCreary "Using Zebrafish to Study BK Ion Channel Trafficking In Vivo" Lydia Perkins “Using Fluorogen Activating Proteins to Study Beta-2-Adrenergic Receptor Trafficking” Emily Simon "Rab GTPase Control of Delta Opioid Receptor Golgi Retention" Zach Weinberg "The role of Golgi positioning in neuronal differentiation" James Winsor "Brachyury Expression Pattern in Strongylocentrotus Purpuratus" Mia Zheng “A preliminary study of Yap1, a candidate mechanical sensor in sea urchins” |
|
|
5/7 |
Yi Wang |
A Toolbox for EGFR Trafficking |
|
Jing Wen |
Unreliable stimulus-evoked activity in the olfactory bulb of an autistic mouse model |
|
|
5/14 |
Ritika Tewari |
Manganese Induces Oligomerization to Promote Downregulation of the Intracellular Trafficking Receptor used by Shiga toxin |
|
Diego Pafundo |
Top-down control of visual response in mouse |
|
|
5/21 |
Idil Ulengin |
Endoplasmic Reticulum Structure in Sickness and in health until graduation do us part… |
|
Charles Ettensohn |
The CRISPR Craze: Targeted Genome Editing |
|
|
5/28 |
Zhongling Sun |
TBA |
|
Simran Saini |
TBA |
|
Fall 2013
|
Date |
Speaker |
Topic |
|
9/4 |
Manojkumar Puthenveedu, Ph.D. |
How to Get Others Ready for Sex Regev-Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF, Baum J, Cowman AF. Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell. 2013 May 23;153(5):1120-33. |
|
|
Alys Cheatle |
Modularity in DNA Binding Preference of a Tbrain Transcription Factor may Allow for more Versatile Transcriptional Responses and Increased Evolvability |
|
9/11 |
Joel McManus, Ph.D. |
RNA Yoga: Sequence Signatures of Folding Flexibility Ritz, J., Martin, J. S., & Laederach, A. (2013). Evolutionary Evidence for Alternative Structure in RNA Sequence Co-variation. (S.-J. Chen, Ed.)PLoS computational biology, 9(7), e1003152. doi:10.1371/journal.pcbi.1003152.s009 |
|
|
Jineta Banerjee |
Elimination of Synaptic Inputs Precedes their Strengthening During Early Postnatal Refinement of a GABA/Glycinergic Circuit in the Mouse Auditory Brainstem |
|
9/18 |
Aaron Mitchell, Ph.D. |
Malassezia: head & shoulders® above the rest |
|
|
Stacie Oliver |
Molecular Mechanisms Governing Stem Cell Niche Architecture in the Drosophila Female Germline |
|
9/25 |
No Journal Club this week due to the Departmental Seminar |
|
|
10/2 |
Aryn Gittis, Ph.D. |
Neurotransmitter Switching in the Adult Brain Regulates Behavior Davide Dulcis et al. (2013) Neurotransmetter Switching in the Adult Brain Regulates Behavior. Science, 340:449. |
|
|
Shawn Burton |
Division of Labor in Mammalian Olfaction: Investigating the Physiology of Mitral and Tufted Cells |
|
10/9 |
John Woolford, Ph.D. |
Using Yeast to Study Ribonucleoprotein Dysfunction in Human Neurodegenerative Diseases Buchan JR, Kolaitis R-M, Taylor JP, Parker R. (2013) Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. Cell 153: 1461-1474. |
|
10/16 |
Brooke McCartney, Ph.D. |
The Good, the Bad, and the Ugly: Commensals, Pathogens, and Next Generation Therapeutics |
|
|
Philip Davidson |
Evolution of the Sporulation Initiation Pathway |
|
10/23 |
Nathan Urban, Ph.D. |
To sleep, perchance to clean |
|
|
Adam Foote |
Investigating the Roles of Micro-RNAS in Development |
|
10/30 |
Adam Linstedt, Ph.D. |
Novel Enzymes in the Sugar Chain to Muscle Health |
|
|
Beril Kumcuoglu |
Tailypo: The Roles of Eukaryote-specific Ribosomal Protein Extensions in Ribosome Assembly |
|
11/6 |
Marcel Bruchez, Ph.D. |
Seriously? We don’t know how antibiotics work YET? Or maybe we do... The controversial role of reactive oxygen. |
|
|
Christopher Pratt |
Two-Color Tracking of an Ion Channe |
|
11/13 |
Rotation 1 Presentations |
|
|
|
Katherine Lagree |
“Temporal Expression of GPP130 in response to Manganese” |
|
|
Lydia Perkins |
“Transmembrane Length-Dependent Partitioning of Oligomerized GPP130 into Lipid Rafts as a Sorting Mechanism” |
|
|
Dylan McCreary |
"MOR Arrestin Signaling." |
|
|
Emily Simon |
“The Role of FGF in Directed Migration of Sea Urchin PMCs” |
|
|
Zachary Weinberg |
"Visualizing Gain Control with 2-Photon Calcium Microscopy" |
|
|
James Winsor |
"Combining FAPs and Voltage Sensitive Dyes in Neurons" |
|
|
Minyan Zheng |
"Regeneration of Serotonergic neurons in starfish" |
|
11/20 |
Sandra Kuhlman, Ph.D. |
Harnessing Plant Cryptochromes to Optically Control Gene Expression in Mammals Konermann S, Brigham MD, Trevino AE, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F. Optical control of mammalian endogenous transcription and epigenetic states. Nature. 2013 Aug 22;500(7463):472-6. doi: 10.1038/nature12466. Epub 2013 Aug 23. |
|
|
Tanvi Shashikant |
"Genome-wide Analysis of Effector Genes in the Sea Urchin Skeletogenic Gene Network" |
|
11/27 |
No Journal Club due to Thanksgiving Break |
|
|
12/4 |
Luisa Hiller, Ph.D. |
The Human Gut: A Bacterial World. |
|
|
Daniel Shiwarski |
Unlocking the DOR to the surface: Trafficking of the δ-Opioid Receptor (DOR) |
Spring 2013
|
Date |
Speaker |
Topic |
|
1/16 |
Ezgi Kunttas-Tatli |
To Dimerize or Not to Dimerize, that is the Question: Role of Dimerization in APC Protein |
|
|
Deborah Makin |
RNA Interference Screens of Trans-Acting Factors for Recursive Splicing in Drosophila |
|
1/23 |
Suchitra Ramachandran |
Statistical Learning of Visual Sequences in Monkey Inferotemporal Cortex depends on the Bidirectional Conditional Probability of the Images |
|
|
Simran Saini |
Mechanism of Membrane Fusion by the Atlastin GTPase |
|
1/30 |
Amanda Soohoo |
Tell me MOR, Tell me MOR: Does your Endocytosis Last Really Long |
|
|
Gregory Smith |
Applying Cellular Crowding Models to Simulations of Virus Capsid Assembly in vitro |
|
2/6 |
Ritika Tewari |
Understanding the Mechanism of GPP130 Sensitivity to Manganese |
|
|
Idil Ulengin |
Dissecting the Catalytic Machinery of Atlastin GTPase |
|
2/13 |
Rotation 2 Presentations |
Anagha Kadam Insight into Strain Adaptability Through the Characterization of a Novel Streptococcal Histidine Kinase Advisor: Hiller Ceren Tuzmen Construction of Lariat Libraries to Identify Alternative Splice Sites in Yeast Advisor: McManus Brendan Redler A Method for Direct Electroelution of Proteins from Two Dimensional Gels Advisor: Minden Amanda Willard A New Way to Study Parkinson's: Induction of Motor Deficits through 6-OHDA Time-course Dopamine Depletion Advisor: Gittis Caitlin Winkler A Tale of Two Cell Types: Mapping Anatomical Projections of the External Globus Pallidus (GPe) Advisor: Gittis |
|
2/14 (2 - 3:15 p.m., Mellon Institute Social Room) |
Rotation 2 Presentations |
Nicholas Audette Advisor: Barth Berquin Feese Neuroanatomical Differences between Layer 2 Neurons Advisor: Barth Vinitha Ganesan The Oligomerization State of Cis-Golgi Protein GPP130 in Response to Golgi Manganese Influx Advisor: Linstedt Lina Song Construction of a Sensor for Monitoring the Activity of ppGlaNAc Transferase 3 Advisor: Linstedt Yizhu Lin Yeast Co-regulation: Looking Under the Hood Advisor: Durand Swati Venkat Characterizing a New Tethering Compound, DC18, as an Anchor for Sparsely Tethered Bilayer Lipid Membranes Advisor: Loesche Malachi Blundon Advisor: Hiller |
|
2/20 |
Phu Van |
Optimizing 2DE Protein Gels for Detection with the SIGI |
|
|
Rachel Vistein |
Sequence of Events: Adrenergic Receptor Tail Sequences Direct Recycling |
|
2/27 |
Mingrui Zhang |
Far-red and NIR Fluoromodules for Multi-color in vivo Imaging |
|
|
Shanna Bowersox |
A Tail of Two Receptors: A Pain Receptor Increases Recycling of the Mu-opioid Receptor |
|
3/6 |
Jigarkumar Desai |
Regulatory Role of Glycerol in Candida albicans Biofilm Formation |
|
|
Olivia Molinar |
Novel Roles for Adenomatous polyposis coli Proteins in Actin Assembly |
|
3/13 |
No Journal Club Due to Spring Break |
|
|
3/20 |
Gino Gallo |
Engineering Fluorogen-Activating-Proteins as Universal Affinity Biosensors |
|
|
Salini Konikkat |
Knitting Together the Ribosome – How Assembly Factors Facilitate Tertiary Interactions during Ribosome Assembly |
|
3/27 |
Han Lai |
Bursts of Horizontal Transfer Activity: Signal or Noise? |
|
4/3 |
Madhumitha Ramesh |
You know a Man by his Friends: Understanding the Roles of the ITS2 Neighborhood in Ribosome Biogenesis |
|
|
Karen Kormuth |
Exploring New Perspectives of Guanine Quadruplex Biology within Ribosomal DNA |
|
4/10 |
John Pettersson |
Substrate Plasticity of GSTA1-1: Single Molecule Characterization of a Disobedient Enzyme |
|
|
Veronica Hinman |
On the Immortality of Television Sets: “Function” in the Human Genome According to the Evolution-free Gospel of ENCODE Graur, D., Zheng, Y., Price, N., Azevedo, R.B., Zufall, R.A., and Elhaik, E. (2013). Genome Biol. Evol. , doi:10.1093/gbe/evt028 | in press.
Ward LD, Kellis M. Evidence of abundant purifying selection in humans for recently acquired regulatory functions. Science. 2012 Sep 28;337(6102):1675-8. Epub 2012 Sep 5. |
|
4/17 |
Elizabeth Ransey |
Comprehensive Mechanistic and Structural Analysis of an RNA-Lariat Debranching Enzyme |
|
|
Sahil Sangani |
From Thermodynamics to NMR Dynamics of Specific Protein-DNA Interactions |
|
4/24 |
Zhongling Sun |
Differential Gene Expression in Primary Mesenchyme Cells Underlies Skeletogenesis in the Sea Urchin Embryo |
|
|
Tina Lee |
Actin in the Nucleus |
|
5/1 |
Yi Wang |
Directed Molecular Evolution to Diversify Malachite Green Activating Peptide |
|
|
Ting Liu |
Probing Viral DNA Structures - What Renders Fluidity to Rigid Viral Genome |
|
5/9 (11 a.m. - 12:15 p.m., Mellon Institute Social Room)
|
Rotation 3 Presentations |
Anagha Kadam Advisor: Hiller Nicholas Audette Characterization of a Putative Lantibiotic Locus in Streptococcus Pneumonia Advisor: Hiller Yizhu Lin Simulation of Tumor Cell Gene Copy Number Progression Advisor: Schwartz Swati Venkat Simulating MultiDomain Evolution Advisor: Durand Lina Song Establishment of Yeast Based Screen System for Ferritin as an MRI Reporter Advisor: Ahrens Malachi Blundon The Role of APC2 Dimerization in Destruction Complex Formation in Drosophila S2 Cells Advisor: McCartney |
|
5/10 (11 a.m. - 12:15 p.m., Mellon Institute Social Room)
|
Rotation 3 Presentations |
Vinitha Ganesan Comparing the Co-evolution of Transcription Start Site Usage and Translation Efficiency Advisor: McManus Caitlin Winkler Enterovirus Meningoencephalitis: Distribution of Virus in Two Fatal Cases Advisor: Wiley Amanda Willard Do Layer 2/3 PV Cells in the Visual Cortex Exhibit Contrast Variance? Advisor: Kuhlman Brendan Redler Advisor: Linstedt Berquin Feese Utility of Anti-microRNAs for the Regulation of Bone Regeneration Under Inflammatory Conditions Advisor: Campbell Ceren Tuzmen VIP as an Immunomodulator to Control Inflammation During Bone Regeneration Advisor: Campbell |
Fall 2012
|
Date |
Speaker |
Topic |
|
8/29 |
Emily Furbee |
Phenotypic Analysis of Hsp27 Phosphorylation Mutants in Drosophila |
|
|
Manoj Puthenveedu |
The Key to Eating (and Digesting) Bugs Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F. Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature. 2012 Jan 15;482(7385):414-8. doi: 10.1038/nature10744. |
|
9/5 |
Merissa Remus |
Cue-Evoked ERK Activation in the Nucleus Accumbens during Reward Seeking: Role for D1 Dopamine Receptors |
|
|
Ayshwarya Subramanian |
Inferring Robust Phyloegenetic Markers from Tumor Data |
|
9/12 |
Jason Talkish |
Disruption of Ribosome Biosynthesis Results in a Shift from Co- to Post-transcriptional pre-rRNA Processing and Breakdown of the Traditional Assembly Hierarchy |
|
|
David Whitney |
Evoking Neural Plasticity in the Visual Cortex Depends on Local Map Structure |
|
9/19 |
Shawn Burton |
A Selective Filter Controls Differential Trafficking in Neurons |
|
|
Philip Davidson |
Specificity of Interaction in Two Component Systems |
|
9/26 |
Adam Foote |
A Specific Mitochondrial Stress Engages Apoptotic Signaling to Cause Deafness |
|
|
Beril Kumcuoglu |
Policing Proteins Under Stress : Immobilization of Specific Proteins as a Function of Environmental Cues |
|
10/3 |
Stacie Oliver |
Flocking and Migration: The Lung as a Homing Niche in a Model of Multiple Sclerosis |
|
|
Christopher Pratt |
Seeing Yourself: The Role of Protocadherins in Neuronal Self-Avoidance |
|
10/10 |
Tanvi Shashikant |
The Role of miRNAs in Stem Cell Quiescence |
|
|
Daniel Shiwarski |
cAMP/cGMP Regulation: Breaking Symmetry During the Neuronal Polarization Process |
|
10/17 |
Ardon Shorr |
Renal Cilia Detect Flow |
|
|
Pieter Spealman |
Nuclear/Mitochondrial Incompatibility as a Mechanism for Speciation |
|
10/24 |
Tara Tappen |
Ribosome Profiling Sheds Light on the Black Box of miRNA Regulation |
|
|
Anmol Grover |
Single Molecule Measurement of Eukaryotic Translation |
|
10/31 |
Jineta Banerjee |
Synaptic Changes are Heterogeneous Along the Tonotopic Axis of the MNTB-LSO Circuit of Mouse Auditory Brainstem During Early Development |
|
|
John Woolford |
Ghosts and Horseless Headmen from the RNA World: Riboswitches that Regulate Fluoride Toxicity Baker JL et al. Widespread Genetic Switches and Toxicity Resistence Proteins for Fluoride. Science. 335:233-235, 2012. Ren et al. Fluoride ion encapsulation by Mg++ ions and phosphates in a fluoride riboswitch. Nature. 486:85-89, 2012. |
|
11/7 |
Santosh Chandrasekaran |
Exploring the Role of Intrinsic Biophysical Diversity in Coding of Information in the Sensory Cortex |
|
|
Aryn Gittis |
GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Cell Energy Expenditure Cell Volume 151, Issue 3, 26 October 2012, Pages 645–657 |
|
11/14 12:30 - 1:30 p.m. |
Rotation 1 Presentations |
Ceren Tuzmen (Dahl Lab) Expression and Purification of Recombinant Lamin Proteins and Quantification of Lamins in Mammalian Cultured Cells Brendan Redler (Barth Lab) Amanda Willard (Barth Lab) Chemical Activation of Cold Circuits in the Spinal Cord Vinitha Ganesan (Urban Lab) Looking for Dendrodendritic Synaptic Junctions in the Olfactory Bulb Primary Neuronal Cultures Caitlin Winkler (Thiels Lab) A Possible Role for the Auditory Cortex in Reward-seeking Behavior Swati Venkat (Ahrens Lab) Yeast-based Screen for Ferritin as a MRI Reporter |
|
11/14 3:30 - 4:45 p.m. |
Rotation 1 Presentations |
Nicholas Audette (Linstedt Lab) In Vitro Pull-down of the Trafficking Receptor GPP130 by Shiga Toxin Berquin Feese (Lindstedt Lab) Regulation of Dynein Binding to Golgi Membranes by Golgin160 Malachi Blundon (Minden Lab) Examination of Mutant APC Proteome Changes in Drosophila melanogaster Early Embryos Lina Song (Minden Lab) The New Strategy for Identification of Low Abundance Protein in 2D Gel Patrick Abbott (Lopez Lab) RNA Interference Screening for Factors that Affect Recursive Splicing Yizhu Lin (McManus Lab) Regulation of Alternative Splicing in Yeast TAD3 Anagha Kadam (Hinman Lab) Wnt Signaling During Endomesoderm Development in Sea Star Embryos |
|
11/21 |
No Journal Club Due to Thanksgiving Holiday |
|
|
11/28 |
Paul Barton |
Doing Some Library Research: Lipocalins as FAPs |
|
|
Alys Cheatle |
Modularity in DNA Binding Preference of a Tbrain Transcription Factor may Allow for more Versatile Transcriptional Responses and Increased Evolvability |
|
12/5 |
Michael Gamalinda |
Factory of Protein Factories: Ribosomal Proteins and the Ribosome Assembly Line |
|
|
Andrew Kehr |
Ongoing Structural and Biochemical Characterizations: ADAR2, 3, 2/3? |
Spring 2012
|
Date |
Speaker |
Topic |
|
1/25 |
Alys Cheatle |
Subtle Changes in DNA Binding Preference May Explain Drastic Rewiring of Tbr Target Genes during Echinoderm Evolution |
|
|
Jineta Banerjee |
Different Rules of Circuit Refinement in Different Parts of the Mouse Lateral Superior Olive |
|
2/1 |
Cas Priddy |
Mammalian Golgi Positioning and the Dynein Motor |
|
|
Fred Lanni, Ph.D. |
When Push Comes to Shove |
|
2/8 |
Paul Barton |
Developing a Novel Lipocalin-based FAP |
|
|
Michael Gamalinda |
Ribosomal Proteins: Step-by-step Choreographers of Ribosome Assembly |
|
2/16 12 - 2 p.m. |
Rotation 2 Presentations |
Philip Davidson Rewiring the Sporulation Initiation Pathway Advisor: Durand Adam Foote The Role of Argonaute Proteins in S. Purpuratus Embryonic Patterning Advisor: Hinman Tara Tappen Echinoderm Argonaute Expression Throughout Development and Movement Towards the HITS-CLIP Protocol Advisor: Hinman Stacie Oliver Who’s the Boss? Investigating APC2 and Organization of the Germline Stem Cell Niche in Drosophila Ovaries Advisor: McCartney Ardon Shorr Elementary, my Dear Watson (& Crick) Advisor: Ettensohn Christopher Pratt Developing Biosensors for the Visualization of Synaptic Activity Advisor: Bruchez Daniel Shiwarski Billion Fold Concentration Range Detection using Structure Illumination Gel Imager (SIGI) for 2D-DIGE Proteomic Analysis Advisor: Minden Tanvi Shashikant Spatial Control of Stem Cell Differentiation using BMP-2 Printed DermaMatrix Advisor: Campbell Pieter Spealman The Gearbox of Creation: Translational Regulation Advisor: McManus Beril Kumcuoglu Cargo Specific Regulation of Clathrin-Mediated Endocytosis Advisor: Puthenveedu |
|
2/22 |
Joel McManus, Ph.D. |
Global Analysis of Gene Regulatory Networks with High-throughput Sequencing and Bioinformatics |
|
|
Ezgi Kunttas-Tatli |
The APC2 Compass: Phosphorylation as a Mechanism to Guide APC2 |
|
2/29 |
Andrew Kehr |
RNA Editing: Structural and Biochemical Characterization of hADARs |
|
|
Bob Murphy, Ph.D. |
Image-derived Generative Models of Cell Organization |
|
3/7 |
Joanna Urban-Ciecko, Ph.D. |
Suppression of BK Channel Current by the Trafficking Molecule beta 4 |
|
|
Deb Makin |
Subcellular mRNA Localization in Drosophila |
|
3/14 |
Spring Break - No Journal Club |
|
|
3/21 |
Santosh Chandrasekaran |
Exploring the Role of Intrinsic Biophysical Diversity in Coding of Information in the Cortex |
|
|
Suchitra Ramachandran |
Characterizing Visual Statistical Learning in Macaque Inferotemporal Cortex |
|
3/28 |
Stephanie Hughes |
Identification and Comparison of Early and Late Otx Targets in Sea Urchins and Sea Stars |
|
4/4 |
Simran Saini |
The Mechanism for Atlastin Mediated ER Membrane Fusion |
|
|
Greg Smith |
Translating Bulk Measures of Viral Capsid Assembly Progress into Insights on Fine-scale Kinetics and Pathways |
|
4/11 |
Amanda Soohoo |
How the Mu-Opioid Receptor Regulates its Own Clathrin-Mediated Endocytosis |
|
|
Ritika Tewari |
Insight into the Mechanism of Manganese-Induced Trafficking of Cis-Golgi Protein GPP130 |
|
4/18 |
Idil Ulengin |
Does Spastin ATPase have a Role in ER Network Formation |
|
|
Mark Macbeth, Ph.D. |
It Dices! It Slices! The structural basis for RNA Interference |
|
4/25 |
Phu Van |
There's no Free Lunch: High Dynamic Range Protein Detection with SIGI |
|
|
Rachel Vistein |
Beta-2 Adrenergic Receptor Recycling Switches from Constitutive to Actin Dependent with PKA Phosphorylation |
|
5/2 |
Mingrui Zhang |
Development of Fluoromodule-based Reporters of Physiological Parameters |
|
|
Jon Minden, Ph.D. |
Question-omics |
|
5/10 (4 p.m.) |
Rotation 3 Presentations |
Ardon Shorr Building Nature's Oldest Machine Advisor: Woolford Tara Tappen The Role of Nop12 in Ribosomal Processing and Assembly Advisor: Woolford Beril Kumcuoglu The Role of TRAMP4 Complex in Turnover of Aberrant Pre-ribosomes Advisor: Woolford Christopher Pratt Dissecting the Destructosome: The Directors of APC2 Incorporation Advisor: McCartney Daniel Shiwarski Advisor: McCartney Adam Foote Optimizing 2D Electrophoresis Gels For Increased Protein Detection Advisor: Minden Tanvi Shashikant The Interaction Between Mu-opioid Receptor and Dynamin and its Role in Mediating Receptor Endocytosis Advisor: Puthenveedu Pieter Spealman GPCR and Glut4 Interactions Advisor: Jarvik Stacie Oliver The miRNA Pathway Modulates Anterior/Posterior and Dorsal/Ventral Patterning in the Sea Urchin Embryo Advisor: Hinman Philip Davidson Predicting the Evolution of Interaction Advisor: Durand |
Fall 2011
|
Date |
Speaker |
Topic |
|
8/31 |
Ashrifia Adomako-Ankomah |
Regulation of Skeletal Morphogenesis by Cell-cell Interactions in the Sea Urchin Embryo |
|
|
Kaitlyn Dykstra |
Yip1A Cycling Between the ER and Golgi is not Required for its ER Structuring Function |
|
9/7 |
Anmol Grover |
Genetically Tagged pH Biosensor for Endosomal Trafficking |
|
|
Marcel Bruchez, Ph.D. |
Using Generative Models to Enhance Superresolution Imaging |
|
9/14 |
Tim Jarvela |
GRASPing Golgi Ribbon Maintenance |
|
|
Merissa Remus |
ERK Activation in the Nucleus Accumbens: Selectivity by Subregion, Type of Motivationally-relevant Stimulus, and Cell Phenotype |
|
9/21 |
Ayshwarya Subramanian |
Understanding Tumor Progression using Phylogenetics |
|
|
Brooke McCartney, Ph.D. |
Stories from the End of the Filament: APC2 Dependent Regulation of the Actin Cytoskeleton |
|
9/28 |
Shana Bowersox |
Connections Between Nicotine and Weight Loss in the Central Nervous System |
|
|
Jigarkumar Desai |
Candida albicans: Why is it Virulent? |
|
10/5 |
Eugenio Gallo |
Dissecting the Complexity of Hematopoiesis by Mass-Cytometry |
|
|
Salini Konikkat |
Much More than Translation: Specialized Functions of Ribosomes |
|
10/12 |
Karen Kormuth |
Much More than a Vegetable: Spinach and the Development of Fluorescently Tagged RNAs |
|
|
Han Lai |
When Metabolite Genes get Together |
|
10/19 |
Ting Liu |
Temperature Induced Phase Transition and Change in Ejection Kinetics of Phage Genome |
|
|
Olivia Molinar |
Head Versus Tail Regeneration in Planaria |
|
10/26 |
John Pettersson |
Diversifying the Sequence Between Neighbouring Domains can Prevent Interdomain Misfolding |
|
|
Madhumitha Ramesh |
You are What You Eat: Why miRNA Might be the Next Sensational Nutritional Supplement |
|
11/2 |
Elizabeth Ransey |
The Structure-based Design of Amyloid Fibril Inhibitors Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature, Vol 475, 7 July 2011. |
|
|
Sahil Sangani |
Understanding the Mechanism of a GPCR-G Protein Complex Formation |
|
11/9 |
Zhongling Sun |
The Mechanism of Gamete Recognition in the Mouse Gagandeep Gahlay, Lyn Gauthier, Boris Baibakov, Olga Epifano and Jurrien Dean. Gamete Recognition in Mice Depends on the Cleavage Status of an Egg's Zona Pellucida Protein. Science. Vol. 329 no. 5988 pp. 216-219,9 July 2010. DOI: 10.1126/science.1188178 |
|
|
Yi Wang |
Rotation of Rotorless F1-ATPaes |
|
11/16 (Mellon Institute Social Room) |
Rotation 1 Presentations 12:30 to 2:20 p.m. |
Tanvi Shashikant MAP Kinase Signaling and Skeletogenesis in Sea Urchin Embryo Advisor: Ettensohn Philip Davidson Unmixing Breast Cancer Expression Data Advisor: Schwartz Adam Foote Muscle-Blind Mutations and Muscle Z-Band Alternative Splicing Advisor: Lopez Tara Tappen Tissue-specific Splicing Patterns of the Drosophila Stunted Gene Advisor: Lopez Stacie Oliver Tagging Vesicular Transporters with Fluorogen-Activating Proteins Advisor: Bruchez Ardon Shorr Occupy Small Street: the Gathering of Yeast Advisor: Lanni Christopher Pratt A Tale of Pain and Relief: Heterologous Signal Activation Downstream of the Mu-Opioid Receptor Advisor: Puthenveedu Daniel Shiwarski Live Cell Imaging of cAMP Signaling Dynamics to Evaluate ß2-Adrenergic Receptor Re-sensitization Advisor: Puthenveedu Shawn Burton Highly Active Layer 2/3 Neurons do not Exhibit Hallmarks of Recent Synaptic Plasticity Advisor: Barth Pieter Spealman Three's a Crowd: APC and Dia Interactions Advisor: McCartney Beril Kumcuoglu |
|
11/23 |
No Journal Club due to Thanksgiving Break |
|
|
11/30 |
Kiran Rafiq |
Linking a Developmental Gene Regulatory Network to Morphogenesis |
|
|
Jason Talkish |
Understanding How Three Proteins Fold rRNA by Chemical Footprinting and Other “Cutting”-Edge Techniques |
|
12/7 |
David Whitney |
Age-Dependent Changes in the Columnar Organization and Plasticity of the Ferret Visual Cortex |
|
|
Emily Furbee |
hsp27 and Programmed Cell Death in Drosophila Development |
Spring 2011
|
Date |
Speaker |
Topic |
|
1/12 |
Brenna McCauley |
Evolution of a Novel Cell Population in Sea Urchin Embryos: Changes in Specification and Cell Fate |
|
1/19 |
Jeanne Morin-Leisk |
Mutational Analysis of a Large GTPase Required for ER Network Formation |
|
|
Kalin Vasilev |
Biosensors for Protein Proximity at the Cell Surface |
|
1/26 |
Anmol Grover |
Understanding Translation at Single Molecule Level |
|
|
Alan Waggoner, Ph.D. |
Optogenetics |
|
2/2 |
Smita Yadav |
At Long Last, a Golgi Receptor Complex for the Dynein Motor! |
|
|
Qi Yan |
Super-resolution Imaging Using Fluorogen Activating Proteins (FAPs) |
|
2/8 (2-4 p.m.) |
Rotation 2 Presentations |
Karen Kormuth Peptide Nucleic Acids (PNAs) as Inhibitors of Nucleolin/rDNA G-quadruplex Binding Advisor: Armitage Sahil Sangani Investigating the Role of Kinesin Head Domain Surface Residues in Tail Domain Binding Advisor: Hackney John Pettersson Translation in a Crowded Environment Advisor: Bruchez Jigarkumar Desai PNAs: Potential Probes for Site-specific Labeling of Eukaryotic Ribosomes Advisor: Bruchez Shanna Bowersox Agonist Stimulated Internalization of a FAP-Tagged µ-Opioid Receptor Advisor: Jarvik Eugenio Gallo Using Biosensors for Detecting Protein Proximity at the Cell Surface Advisor: Jarvik Madhumitha Ramesh Investigating the Role of RhoB in Actin-mediated b2AR Recycling Advisor: Puthenveedu |
|
2/9 (12:30-2 p.m.) |
Rotation 2 Presentations |
Ting Liu Study of hADAR2 Catalytic Domain Mutants – How Substrate Specificity Information is Hidden in the Structure Advisor: Macbeth Elizabeth Ransey Purification, Crystallization and Mechanistic Studies of RNA Lariat De-branching Enzyme,DBR1 Advisor: Macbeth Salini Konikkat Cell-cycle Dependent Phosphorylation of APC2 in Drosophila Embryos Advisor: McCartney Zhongling Sun Spatial and Temporal Expression of alx1-like in the Sea Urchin Embryo Advisor: McCartney Han Lai Protein Location and Sorting Pathway: A Hidden Markov Approach Advisor: Murphy Yi Wang Application of Lanthanide Ions on NMR Analysis of EcoRV Advisor: Rule Olivia Molinar Characterization of Axonal Transport Using High Resolution Imaging Methods Advisor: Yang |
|
2/16 |
Bradley Yates |
Progress Toward Creation of an scFv-based Protein-Protein Interaction Biosensor |
|
|
Kaitlyn Dykstra |
How Does Yip1A Structure the Mammalian Endoplasmic Reticulum? |
|
2/23 |
Emily Furbee |
Designing a Better in vivo Autophagy Reporter |
|
|
Nathan Urban, Ph.D. |
A Dimorphic Pheromone Circuit in Drosophila from Sensory Input to Descending Output Ruta V, Datta SR, Vasconcelos ML, Freeland J, Looger LL, Axel R. Nature 468, 686–690 (02 December 2010). doi:10.1038/nature09554 |
|
3/2 |
Ashrifia Adomako-Ankomah |
Regulation of Skeletal Morphogenesis in the Sea Urchin Embyro |
|
|
Jing Wen |
Input Specific Critical Periods for Experience-dependent Plasticity in Layer 2/3 Pyramidal Neurons |
|
3/9 |
No Journal Club - Spring Break |
|
|
3/16 |
Timothy Jarvela |
Understanding the Dynamics of the Golgi Through Acute Inactivation |
|
|
Veronica Hinman, Ph.D. |
Phenotypic Robustness Conferred by Apparently Redundant Transcriptional Enhancers Frankel N, Davis GK, Vargas D, Wang S, Payre F, Stern DL. Nature. 466(7305):490-3, 2010 Jul 22. |
|
3/23 |
Merissa Remus |
Region-specific ERK Activation in the Nucleus Accumbens in Response to Reward-predictive Cues: Does Behavioral Context Matter? |
|
|
Javier Lopez, Ph.D. |
Is Aging Necessary? Sexual Antagonism, Epistasis and Deleterious Pleiotropy of Lifespan-extending Mutations in Drosophila Maguire et al. Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. PLoS Genetics 6:e1001037, 2010. |
|
3/30 |
Ayshwarya Subramanian |
Inferring Evolution of Cell Lineages in Breast Cancer |
|
|
Jesse Sheehan |
Impact of Global and Local Attention on Neuronal Activity in Inferotemporal Cortex Perceptual psychologists have made frequent use of hierarchical displays to analyze global and local visual perception in humans. Hierarchical displays are well suited to this purpose because they allow measuring responses to the same shape both at the level of the whole object and at the level of its parts. A key phenomenon discovered by the use of such stimuli is the global advantage effect: humans report global shape faster then local shape. Inferotemporal cortex (IT), as the terminus of the ventral stream, a chain of areas dedicated to pattern vision, contains neurons selective for complex images. Recent work in the laboratory has shown that IT neurons in the macaque monkey exhibit a signal for global information ~30ms sooner than local information while passively viewing hierarchical displays. My research aims to expound upon this finding by requiring the active processing of the global and local content of the displays. Monkeys are cued which level (global or local) of the display to attend to, and must respond with the identity (shape) of the object at that level. This will attempt to answer two main questions: Do monkeys exhibit a behavioral global advantage effect while performing such a task? Is the discriminative signal latency in IT neurons the same during active as during passive processing? |
|
4/6 |
Mark DeBlois |
Continuous Sensory Input is Not Required to Maintain Synaptic Strength after Plasticity Onset in the Mouse Barrel Cortex |
|
|
Jason Talkish |
Structuring the Preribosome One Subcomplex at a Time: in vivo RNA Footprinting Reveals the RNA Binding Function of Nop12 |
|
4/13 |
Santosh Chandrasekaran |
Exploring the Role of Diversity in Cortical Neural Circuits |
|
|
Jineta Banerjee |
Knocking out GABAA Receptor in the Mouse Auditory Brainstem in a Tissue Specific Manner |
|
4/20 |
Kiran Rafiq |
Linking a Developmental Gene Regulatory Network to Morphogenesis |
|
|
Alys Cheatle |
Subtle Changes in DNA Binding May Explain Drastic Rewiring of Tbr Target Genes during Echinoderm Evolution |
|
4/27 |
David Whitney |
Evoking Neural Plasticity in the Visual Cortex Depends on Local Map Structure |
|
|
Cassandra Priddy |
The Role of Ykt6 in Golgi Membrane Fusion Events |
|
5/4 (Mellon Institute Social Room, 12:30 - 1:30 p.m.) |
Rotation 3 Presentations |
Yi Wang The Role of GMAP210 and G160 Interaction in Golgi Positioning Advisor: Linstedt Sahil Sangani Cloning, Expression and Purification of scDBR1 for Mechanistic and Crystallographic Studies Advisor: Macbeth Jigarkumar Desai Crystal Structure of hADAR2 Catalytic Domain Mutant: Unraveling the Mechanism behind Substrate Specificity Advisor: Macbeth Shanna Bowersox Effects of an Inflammatory Environment on Gene Expression of BMP2-induced Osteoblastic Differentiation of C2C12 Progenitor Cells Advisor: Campbell Elizabeth Ransey The Effects of Inflammation on Muscle-Derived Stem Cell (MDSC) Differentiation: Implications for Stem-Cell Therapy Advisor: Campbell |
|
5/5 (Mellon Institute Social Room, 10 - 11:10 a.m.) |
Rotation 3 Presentations |
Ting Liu Energetic Study of Viral Genome Ejection Advisor: Evilevitch Madhumitha Ramesh The Role of Ribosomal Protein L17 in Ribosome Assembly Advisor: Woolford Salini Konikkat The Role of Ribosomal Protein L17 in Ribosome Assembly Advisor: Woolford Han Lai Inferring Events in Species Trees with Short Branches Advisor: Durand Karen Kormuth Regulation of the Patterning of the Sea Urchin Embryonic Skeleton Advisor: Ettensohn Zhongling Sun Testing the Role of APC2 SAMP Repeats in Wnt Signaling in Drosophila Embryos Advisor: McCartney Olivia Molinar Investigating the Role of Cell Cycle Dependent Phosphorylation in APC2 Activity Advisor: McCartney Eugenio Gallo Understanding the Biology of Aging via Alternative Splicing Differences in Drosophila melanogaster Advisor: Lopez |
Fall 2010
|
Date |
Speaker |
Topic |
|
8/25 |
Paul Barton |
Interfering with RNAi: Evasion of Antiviral Activity |
|
|
Michael Gamalinda |
HOTAIR Just Got Hotter: lincRNAS Could Actually Link |
|
9/1 |
Nathan Hsu |
Circadian and Social Cues Regulate Ion Channel Trafficking |
|
|
James Hughes |
DNA Zip Codes Control an Ancient Mechanism for Gene Targeting to the Nuclear Periphery Ahmed, S. et al. DNA Zip Codes Control an Ancient Mechanism for Gene Targeting to the Nuclear Periphery. Nature Cell Biology 2, 111-118, 2010. |
|
9/8 |
Stephanie Hughes |
Evolutionary Mirages: Illusions of Conserved Structures in Enhancers Lusk RW, Eisen MB. Evolutionary Mirages: Selection on Binding Site Composition Creates the Illusion of Conserved Grammars in Drosophila Enhancers. PLoS Genet 6(1): e1000829, 2010. |
|
|
Andrew Kehr |
A Complex(in) Switch Mechanism for SNARE-Mediated Fusion Giraudo, et. al. Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion. Science 323: 512-6, 2009. |
|
9/15 |
Andrew Markham |
mRNA Quality Control: Evidence for a Novel De-capping Enzyme Jiao X, Xiang S, Oh C, Martin C, Tong L, Kiledjian M. Identification of a quality-control mechanism for mRNA 5'-end capping. Nature:1-5, 2010. |
|
|
Ashita Magal |
NADPH: The Gatekeeper for Drosophila Apoptosis Yang et. al. Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. The Embo Journal, 2010. |
|
9/22 |
Deborah Makin |
Dissecting the CTD Code of RNA Polymerase II: Phosphorylation of Ser7 Across Protein-coding Genes Tietjen JR, et al. Chemical-genomic dissection of the CTD code. Nat. Struct. Mol. Biol. 17: 1154-1161, 2010. |
|
|
Ezgi Kunttas-Tatli |
Testing Interactions between APC2 and Armadillo in Wnt Signaling |
|
9/29 |
Sailatha Ravi |
DNA Packaging Role of phi-29 Homomeric Ring ATPase Moffitt et al., Intersubunit coordination in a homomeric ring ATPase, Nature, 2009. |
|
|
Suchitra Ramachandran |
Information is Wealth: Midbrain Dopamine Neurons Signal Preference for Advance Information about Upcoming Rewards Bromberg-Martin E and Hikosaka O. Midbrain Dopamine Neurons Signal Preference for Advance Information about Upcoming Rewards. Neuron, 63(1):119-126, 2009 July 16. |
|
10/6 |
Simran Saini |
Staph vs. Staph: A New Way to Attack Staphylococcus aureus Iwase et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature, 2010. |
|
|
Gregory Smith |
Codon Pair Bias: A Powerful Tool in Rational Influenza Vaccine Design Mueller, S. et al. Live attenuated influenza virus vaccines by computer-aided rational design. Nature Biotechnology 28, 723-726, 2010. |
|
10/13 |
Amanda Soohoo |
With Curves like Those, I'll Go Inside: How Membrane Curvature Proteins Nucleate Endocytosis Henne et. al. FCHo Proteins Are Nucleators of Clathrin-Mediated Endocytosis. Science 328, June 2010. |
|
|
Ritika Tewari |
Early to Late Endosome Transition Dmitry Poteryaev,Sunando Datta,Karin Ackema, Marino Zerial and Anne Spang.Identification of the Switch in Early-to-Late Endosome Transition. Cell 141, 497–508, 30 Apr 2010. |
|
10/20 |
Idil Ulengin |
To be or not to be Translocated: A Quality Control Pathway that Regulates Translocation during ER Stress Leads to Neurodegeneration Rane NS et al. Reduced translocation of Nascent Prion protein during Er stress contributes to Neurodegeneration. Developmental Cell, 15:359-370, 2008. |
|
|
Phu Van |
Targeted Proteomics with Selected Reaction Monitoring Picotti P, Bodenmiller B, Mueller L, Domon B, Aebersold R.Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics. Cell, 138(4)795-806, 2009. |
|
10/27 |
Rachel Vistein |
Hanging in the Balance: CDK5 and Calcineurin Regulate the Exocytosis of Presynaptic Vesicles Kim SH and Ryan TA. CDK5 Serves as a Major Control Point in Neurotransmitter Release. August 2010. |
|
|
Mingrui Zhang |
Rescuing Vision in Retinitis Pigmentosa Patients Busskamp et al. Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa. Science (329), 413-417, 2010. |
|
11/3 |
Shantanu Bhattacharyya |
NMR Structure of Single Chain Antibody Fragment M8 |
|
|
Russell Schwartz, Ph.D. |
How a Few Years of Work Can Save You a Millisecond Shaw DE, Maragakis P, Lindorff-Larsen K, Piana S, Dror RO, Eastwood MP, Bank JA, Jumper JM, Salmon JK, Shan Y, Wriggers W. Atomic-Level Characterization of the Structural Dynamics of Proteins. Science:341-346, 15 October 2010. |
|
11/10 (12:30 - 1:40 p.m.) |
Rotation 1 Presentations |
Shanna Bowersox Effects of Chronic Morphine on Trafficking of the mu Opioid Receptor Advisor: Puthenveedu Ting Liu Two Small GTPases & One Big Question- Recycling Study of β2 Adrenergic Receptors Zhongling Sun Characterizing Neuronal Diversity in the Neocortex Advisor: Barth Madhumitha Ramesh Correlations in Intrinsic Properties between Sister and Non-sister Mitral Cells Advisor: Urban John Pettersson Osmotic Suppression of Giant Genome Phage λ Ejection Advisor: Evilevitch Han Lai Human Papillomavirus (HPV) Capsid Formation Advisor: Schwartz Sahil Sangani NMR Structure of Single-chain Antibody (ScFv) K7 Advisor: Rule |
|
11/11 (12:30 - 1:40 p.m., Mellon Institute Social Room) |
Rotation 1 Presentations |
Yi Wang Altering Dye Binding with Directed Mutagenesis of a Fluorogen Activating Peptide Advisor: Bruchez Elizabeth Ransey Progress in Detection of 5HTR2A Internalization in Live Cells Using FAP-based Biosensor Technology Advisor: Jarvik Salini Konikkat The Role of DNA Replication and Cell Division in Re-wiring Developmental Gene Regulatory Networks Advisor: Ettensohn Jigarkumar Desai Adenomatous Polyposis Coli(APC): Understanding the Mode of Regulation of its Activity in a Cell-cycle Dependent Manner in the Drosophila Syncytial Blastoderm Advisor: McCartney Eugenio Gallo A Rapid and Systematic Approach for Detecting Protein-protein Interactions in Candida Albicans Advisor: Mitchell Olivia Molinar RNA Recognition by DNA Nanotags: A New Approach to Fluorescent Labeling of RNA Advisor: Armitage Karen Kormuth Expression and Purification of RNA Debranching Enzyme Advisor: Macbeth |
|
11/17 |
Shantanu Ganguly |
Quorum Sensing in Candida albicans Biofilms |
|
|
John Holleran |
Cell Surface Detection of Proteins Implicated in Cystic Fibrosis |
|
11/24 |
No Journal Club - Thanksgiving Week |
|
|
12/1 |
Elmer Ker |
Toward Spatial Control of Complex Tissues using Growth Factor Patterns and Fiber Alignment |
|
|
Aaron Mitchell, Ph.D. |
Septins Skore |