What psychological and neural mechanisms support human perception, learning, memory, language, problem-solving and social behaviors? Carnegie Mellon has been at the forefront in studying these questions for over five decades. Our research and training programs strongly interdisciplinary with an emphasis on the precise specification of the mechanisms underlying mental processes and behaviors, often incorporating neuroscientific data and computational models. Another hallmark of our programs is their integration across different levels of analysis: from structural and functional properties of neural circuits to fine-grained analysis of behavior, and from psychological models and large-scale simulations to intelligent artificial systems. We utilize a wide variety of methods to characterize behavior in normal and brain-damaged populations of children and adults, structural imaging, functional neuroimaging (including EEG, MEG, MRI and fNIRS), and computational modeling and simulation. We have helped to build science-based cognitive tutors, to understand how learning works across many different systems, to foster the creation of health neuroscience, and to put our findings into real-world practice in both the translational and commercial domains.