Carnegie Mellon University

Publications and Patents

Selected Publications

  1. T. T. Schug, R. Abagyan, B. Blumberg, T. J. Collins, D. Crews, P. L. DeFur, S. M. Dickerson, T. M. Edwards, A. C. Gore, L. J. Guillette, T. Hayes, J. J. Heindel, A. Moores, H. B. Patisaul, T. L. Tal, K. A. Thayer, L. N. Vandenberg, J. C. Warner, C. S. Watson, F. S. vom Saal, R. T. Zoeller, K. P. O’Brien, and J. P. Myers, Designing endocrine disruption out of the next generation of chemicals, Green Chem., 2013,15, 181-19, DOI: 10.1039/c2gc35055
  2. Thaddeus T. Schug, Anne F. Johnson, Linda S. Birnbaum, Theo Colborn, Louis J. Guillette, Jr David, Crews, Terry Collins, Ana M. Soto,
Frederick S. vom Saal, John A. McLachlan, Carlos Sonnenschein, and Jerrold J. Heindel, Minireview: Endocrine Disruptors: Past Lessons and Future Directions. Molecular Endocrinology 2016, DOI: 10.1210/me.2016-1096
  1. Yusuf Onundi, Bethany A. Drake, Ryan T. Malecky, Matthew A. DeNardo, Matthew R. Mills, Soumen Kundu, Alexander D. Ryabov, Evan S. Beach, Colin P. Horwitz, Michael T. Simonich, Lisa Truong, Robert L. Tanguay, L. James Wright, Naresh Singhal and Terrence J. Collins, A multidisciplinary investigation of the technical and environmental performances of TAML/peroxide elimination of Bisphenol A compounds from water. Green Chemistry 2017, 19, 4234–4262, DOI: 10.1039/c7gc01415e
    Within twelve days after the 8/2/17 publication, the paper had achieved an Altimetric Attention Score of 103, placing it in the top 1% of >8M research outputs:
  2. M. R. Mills, K. Arias-Salazar, Alice Baynes, L. Q. Shen, J. Churchley, N. Beresford, C. Gayathri, R. G. Gil, R. Kanda, S. Jobling, T. J. Collins, Removal of ecotoxicity of 17α-ethinylestradiol using TAML/ peroxide water treatment. Sci. Rep. 2015, 5, 10511: doi: 10.1038/srep10511
  3. Soumen Kundu, Arani Chanda, Sushil K. Khetan, Alexander D. Ryabov, and Terrence J. Collins, TAML Activator/Peroxide Catalyzed Facile Oxidative Degradation of the Persistent Explosives Trinitrotoluene and Trinitrobenzene in Micellar Solutions Environ. Sci. Technol. 2013, 47 (10), 5319–5326, DOI: 10.1021/es4000627
  4. Longzhu Q. Shen, Evan S. Beach, Yan Xiang, Dwight J. Tshudy, Natalya Khanina, Colin P. Horwitz, Mark E. Bier, and Terrence J. Collins, Rapid, Biomimetic Degradation of Sertraline in Water by TAML Catalytic Activation of Hydrogen Peroxide, Environ. Sci. Technol. 2011, 45 (18), 7882–7887, DOI: 10.1021/es201392k
  5. Gupta, S. S., M. Stadler, C. A. Noser, A. Ghosh, B. Steinhoff, D. Lenoir, C. P. Horwitz, K.-W. Schramm, T. J. Collins. Rapid total destruction of chlorophenol pollutants by activated hydrogen peroxide. Science 2002, 296, 326–328.
  6. J. L. Chen; S. Ravindran; S. Swift; L. J. Wright; N. Singhal, Catalytic oxidative degradation of 17α-ethinylestradiol by Fe(III)-TAML/H2O2: Estrogenicities of the products of partial, and extensive oxidation. Water research 2012, 46(19), 6309-18.
  1. Nicola Beresford, Alice Baynes, Rakesh Kanda, Matthew R. Mills, Karla Arias-Salazar, Terrence J. Collins, Susan Jobling, Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency. JOVE, September 2016, 115, e54243, 1–16:; doi:10.3791/54243
  2. Collins TJ, DeNardo, MA, Warner GR, Gordon-Wylie SW, Ellis WC, Far Superior Oxidation Catalysts Based on Macrocyclic Compounds. US Patent Filing September 25, 2016. PCT Filing at same time.
  3. Lisa Truong, Matthew A. DeNardo, Soumen Kundu, Terrence J. Collins, and Robert L. Tanguay, Zebrafish Assays as Developmental Toxicity Indicators in the Green Design of TAML Oxidation Catalysts. Green Chem. 2013, 15, 2339–2343, DOI:10.1039/C3GC40376A
  4. W. Chadwick Ellis, Camly T. Tran, Riddhi Roy, Marte Rusten, Andreas Fischer, Alexander D. Ryabov, Bruce Blumberg, and Terrence J. Collins, Designing green oxidation catalysts for purifying environmental waters. J. Am. Chem. Soc. 2010, 132, 9774-81 DOI: 10.1021/ja102524v
  1. Terrence J. Collins and Alexander D. Ryabov, Targeting of High-Valent Iron TAML Activators at Hydrocarbons and Beyond. Chemical Reviews 2017, 117 (13), pp 9140–9162,
  2. Matthew A. DeNardo, Matthew R. Mills, Alexander D. Ryabov, and Terrence J. Collins, Unifying Evaluation of the Technical Performances of Iron-Tetra-amido Macrocyclic Ligand Oxidation Catalysts. J. Am. Chem. Soc. 2016, 138 (9), 2933–2936, DOI: 10.1021/jacs.5b13087
  3. Chang W-C, Li J, Lee JL, Cronican AA, Guo Y, Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4’-Methoxycyclopenin Biosynthesis. Journal of the American Chemical Society 2016, 138: 10390-10393
  4. Ren Q, Guo Y, Mills MR, Ryabov AD, Collins TJ, On the Iron(V) Reactivity of an Aggressive Tail-Fluorinated TAML Activator. European Journal of Inorganic Chemistry 2015, 1445–1452
  5. Soumen Kundu, Jasper Van Kirk Thompson, Longzhu Q. Shen, Matthew R. Mills, Emile L. Bominaar, Alexander D. Ryabov, and Terrence J. Collins, Activation Parameters as Mechanistic Probes in the TAML Iron(V)– Oxo Oxidations of Hydrocarbons. Chem. Eur. J. 2015, 21(4), 1803-10, doi: 10.1002/chem.201405024.
  6. Maria Emelianenko, Diego Torrejon, Matthew A. DeNardo, Annika K. Socolofsky, Alexander D. Ryabov · Terrence J. Collins, Estimation of rate constants in nonlinear reactions involving chemical inactivation of oxidation catalysts. J Math Chem 2014, 52, 1460–1476, doi:10.1007/s10910-014-0322-4
  7. A. D. Ryabov, T. J. Collins, Mechanistic Considerations on the Reactivity of Green FeIII-TAML Activators of Peroxides. Adv. Inorg. Chem. 2009, 61, 471–521
  1. Mauter, M.S., Zucker, I., Perreault, F., Werber, J.R., Kim, J.H. and Elimelech, M., The role of nanotechnology in tackling global water challenges. Nature Sustainability 20181(4), 166.
  2. Gingerich, D.B., Sun, X., Behrer, A.P., Azevedo, I.L. and Mauter, M.S. Spatially resolved air-water emissions tradeoffs improve regulatory impact analyses for electricity generation. Proceedings of the National Academy of Sciences 2018114(8), 1862-1867.
  3. Churchley, J., Collins, T. & Jobling, S. Catalytic oxidation of pharmaceutical compounds in wastewater effluents. UKWIR Report 13/WW/17/14 (2013) (ISBN: 1 84057 689 8). UKWIR London. Available online at:
  4. Khetan, S. K., T. J. Collins, Human Pharmaceuticals in the Aquatic Environment: A Challenge to Green Chemistry, Chem. Rev., 2007, 107, 2319–2364.
  5. Benotti M, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA (2009) Pharmaceuticals and endocrine disrupting compounds in U.S. drinking waters. Environ Sci Technol 43: 597-603
  6. Snyder SA, Adham S, Redding AM, Cannon FS, DeCarolis J, Oppenheimer J, Wert EC, Yoon Y (2006) Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals. Desalination 202: 156-181
  1. Fernando S, Renaguli A, Milligan MS, Pagano JJ, Hopke PK, Holsen TM, Crimmins BS, Comprehensive Analysis of the Great Lakes Top Predator Fish for Novel Halogenated Organic Contaminants by GCxGC-HR-ToF. Environmental Science and Technology 2018, 52, 2909-2917.
  2. Fakouri Baygi S, Crimmins BS, Hopke PK, Holsen, TM, Comprehensive Emerging Chemical Discovery: Perfluorinated and Polyfluorinated Compounds in Lake Michigan Trout. Environmental Science and Technology 2016, 50:9460-9468.
  3. Gorkowski, K. J., Donahue, N., and Sullivan, R. C. Determination of biphasic core–shell droplet properties using aerosol optical tweezers. Environ. Sci. Process. Impacts 2018, In Press.
  1. Nicola Beresford, Alice Baynes, Rakesh Kanda, Matthew R. Mills, Karla Arias-Salazar, Terrence J. Collins, Susan Jobling, Use of a Battery of Chemical and Ecotoxicological Methods for the Assessment of the Efficacy of Wastewater Treatment Processes to Remove Estrogenic Potency. JOVE 2016, 115, 1–16:; doi:10.3791/54243
  2. Janesick AS, Dimastrogiovanni G, Vanek L, Boulos C, Chamorro-García R, Tang W, Blumberg B., On the utility of ToxCastTM and ToxPi as methods for identifying new obesogens. Environ Health Perspect 2016, 124, 1214–1226,
  3. M. R. Mills, K. Arias-Salazar, Alice Baynes, L. Q. Shen, J. Churchley, N. Beresford, C. Gayathri, R. G. Gil, R. Kanda, S. Jobling, T. J. Collins, Removal of ecotoxicity of 17α-ethinylestradiol using TAML/ peroxide water treatment. Sci. Rep. 2015, 5, 10511, doi: 10.1038/srep10511
  4. McRobb FM, Kufareva I, Abagyan R., In silico identification and pharmacological evaluation of novel endocrine disrupting chemicals that act via the ligand-binding domain of the estrogen receptor α. Toxicol Sci. 2014, 141 (1), 188-97.
  5. McRobb FM, Sahagún V, Kufareva I, Abagyan R, In silico analysis of the conservation of human toxicity and endocrine disruption targets in aquatic species. Environ Sci Technol. 2014, 48(3), 1964-72, doi: 10.1021/es404568a.
  6. Christopher D. Kassotis, Luke R. Iwanowicz, Denise M. Akob, Isabelle M. Cozzarelli, Adam C. Mumford, William H. Orem, Susan C. Nagel, Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site. Sci Total Environ 2016,
  7. Truong L, Reif DM., St. Mary L, Geier M, Truong HD, Tanguay, RL, Multi-dimensional in vivo hazard assessment using zebrafish. Toxicol. Sci. 2014, 137 (1), 212-233, doi: 10.1093/toxsci/kft235
  8. Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL, Advanced Morphological — Behavioral Test Platform Reveals Neurodevelopmental Defects in Embryonic Zebrafish Exposed to Comprehensive Suite of Halogenated and Organophosphate Flame Retardants. Toxicol. Sci. 2015, 145(1), 177–195, doi: 10.1093/toxsci/kfv044
  9. Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R et al., Concerns over use of glyphosate-based herbicides and risks associated with exposures: A consensus statement. Environmental Health: A Global Access Science Source 2016, 15(1)
  10. Richard Owen and Susan Jobling, Environmental science: The hidden costs of flexible fertility. Nature 2012, 485, 441, doi:10.1038/485441a.
  1. Chamorro-Garcia, R., Diaz-Castillo, C., Shoucri, B.M., Käch, H., Leavitt, R., Shioda, T., and Blumberg, B. Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice. Nature Communications 2017, 8(1), 2012.
  2. A. Akintonwa, O. Awodele, A. T. Olofinnade, C. Anyakora, G. O. Afolayan, H. A. B. Coker. Assessment of the Mutagenicity of Some Pharmaceutical Effluents. American Journal of Pharmacology and Toxicology 2009, 4, 144-150, doi: 10.3844/ajptsp.2009.144.150
  3. Ifegwu, OC, Anyakora, C. Polycyclic Aromatic Hydrocarbons: Part II, Urine Markers, Adv Clin Chem. 2016, 75, 159-83, doi:10.1016/bs.acc.2016.03.001.
  4. Kassotis CD, Klemp KC, Vu DC, Lin C-H, Meng C-X, Besch-Williford CL, Pinatti L, Zoeller RT, Drobnis EZ, Balise VD, Isiguzo CJ, Williams MA, Tillitt DE, Nagel SC, Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice. Endocrinology 2015, 156, 4458–4473.
  5. Baldwin, KR, Horman, B, Phillips, AL, McRitchie, SL, Watson, S, Deese-Spruill, J, Stapleton, HM, Jima, D, Sumner, S, Patisaul, HB, EDC Impact: Molecular Effects of Developmental FM 550 Exposure in Wistar Rat Placenta and Fetal Forebrain. Endocrine Connections 2018. [Invited Contribution; NIEHS extramural paper of the month]
  6. Sullivan, AW, Elsworth, CB, Stetzik, LA, Perry, A, D’Addezio, AS, Cushing, BS, Patisaul, HB, A novel model for neuroendocrine toxicology: Neurobehavioral effects of BPA. Endocrinology 2014. 155(10), 3867-3881. [cover article]
  7. Angle BM, Do RP, Ponzi D, Stahlhut RW, Drury BE, Nagel SC, Welshons WV, Besch-Williford CL, Palanza P, Parmigiani S, vom Saal FS, Taylor JA, Metabolic disruption in male mice due to fetal exposure to low but not high doses of bisphenol A (BPA): Evidence for effects on body weight, food intake, adipocytes, leptin, adiponectin, insulin and glucose regulation. Reproductive Toxicology 2013, 42, 256–268,
  8. Taylor JA, vom Saal FS, Welshons WV, Drury B, Rottinghaus G, Hunt PA, Toutain P-L, Laffont CM, VandeVoort CA, Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure. Environ Health Perspect 2011, 119:422–430, doi:10.1289/ehp.1002514
  9. Palanza P, Nagel SC, Parmigiani S, vom Saal FS, Perinatal exposure to endocrine disruptors: Sex, timing and behavioral endpoints. Current Opinion in Behavioral Sciences 2016, 7, 69-75.
  10. Wadzinski TL, Geromini K, McKinley Brewer J, Bansal R, Abdelouahab N, Langlois MF, Takser L, Zoeller RT. Endocrine disruption in human placenta: expression of the dioxin-inducible enzyme, CYP1A1, is correlated with that of thyroid hormone-regulated genes. J Clin Endocrinol Metab. 2014, 99( 12), E2735-2743.
  11. Gauger KJ, Giera S, Sharlin DS, Bansal R, Iannacone E, Zoeller RT. Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells. Environ Health Perspect. 2007, 115(11), 1623-1630.
  1. Ahern, A. T., Goldberger, L., Jahl, L., Thornton, J. and Sullivan, R. C., Production of N2O5 and ClNO2 through nocturnal processing of biomass-burning aerosol. Environ. Sci. Technol. 2018, 52(2), 550–559, doi:10.1021/acs.est.7b04386.
  2. Gorkowski, K., Donahue, N. M. and Sullivan, R. C., Emulsified and Liquid–Liquid Phase-Separated States of α-Pinene Secondary Organic Aerosol Determined Using Aerosol Optical Tweezers. Environ. Sci. Technol. 2017, 51(21), 12154–12163, doi:10.1021/acs.est.7b03250.
  3. Sullivan, R. C., Moore, M. J. K., Petters, M. D., Kreidenweis, S. M., Roberts, G. C. and Prather, K. A., Timescale for hygroscopic conversion of calcite mineral particles through heterogeneous reaction with nitric acid. Phys. Chem. Chem. Phys. 2009, 11(36), 7826, doi:10.1039/b904217b.
  1. Holt, B. D.; Arnold, A. M.; Sydlik, S. A., In It for the Long Haul: The Cytocompatibility of Aged Graphene Oxide and Its Degradation Products. Adv. Health. Mater. 2016, 5, 3056- 3066.
  2. Sydlik, S. A.; Swager, T. M. Functional Graphenic Materials via a Claisen Rearrangement. Adv. Func. Mater. 2013, 23, 1873- 1882.
  3. Qiu, Y.; Worch, J. W.; Fortney, A.; Gayathri, C.; Gil, R. R.; Noonan, K. J. T. Nickel-Catalyzed Suzuki Polycondensation for Controlled Synthesis of Ester-Functionalized Conjugated Polymers. Macromolecules 2016, 49, 4757-4762.
  4. Tsai, C.-H.; Fortney, A.; Qiu, Y.; Gil, R. R.; Yaron, D. Kowalewski, T.; Noonan, K. J. T. Conjugated Polymers with Repeated Sequences of Group 16 Heterocycles Synthesized through Catalyst-​Transfer Polycondensation. Journal of the American Chemical Society 2016, 138, 6798-6804.
  5. PCT on Smart Catalytic Membranes (135 pages): L. J. Wright, 32557 Oxidation Membrane, PCT/NZ2016/050066