supported membrane

Biological Physics

Supramolecular Structures Lab
Lösche/Heinrich Group


Jennifer C. Lee, NIH-NHLBI, Lab of Protein Conformation and Dynamics

Molecular interactions of Parkinson's α-synuclein with membranes.
Νeutron reflectometry is employed to investigate the interaction of α-synuclein with lipid membranes. In these studies, we discovered the interaction between α-synuclein and glucocerebrosidase, the enzyme deficient in Gaucher disease, to explain why mutations in GBA, the gene encoding glucocerebrosidase, is a risk factor for Parkinsonism.

Robert S. Cantor, Dartmouth College, Dept. of Chemistry

Neutrotransmitter interaction with lipid membranes.
The activity of many membrane proteins is remarkably sensitive to slight changes in the composition of the lipid bilayer in which they are embedded. An example is the (unspecific) interaction of neurotransmitters with the post-synaptic membrane which we aim to quantify in model studies.

Gintaras Valincius, Vilnius Gedimino Tech Univ, Vilnius, Lithuania

Solid Supported Tethered Membrane Systems. More ...
Mechanisms of Toxicicity of the Alzheimer's Peptide Amyloid β. More ...
Membrane Association of α-Hemolysin - Functional Toxin Pores in Tethered Membranes. More ...

Daniel C. Nelson, IBBR and U Maryland Dept. of Veterinary Medicine

Enzybiotics as antimicrobial agents.
PlyC, a bacteriophage-encoded endolysin is a potent agent for controlling intracellular Streptococci (Spy) that often result in refractory infections. We established that PlyCB interacts strongly with phosphatidylserine (PS) whereas its interaction with other lipids is weak, suggesting specificity for PS as its cellular receptor.

Siddartha Datta and Alan Rein, HIV Drug Resistance Program, National Cancer Institute, NIH, Frederick, MD

Initial steps of viral assembly: Association of retroviral Gag proteins with artificial bilayers. More ...
NIGMS-funded: R01 GM101647

Kris Dahl, Carnegie Mellon University, Biomedical Engineering

Quantification of Progerin Recruitment to Membranes: The Role of Farnesylation and Local Electrostatic Interactions in HGPS

Arne Gericke, Worcester Polytechnic Institute, Worcester, MA

Cellular control mechanisms of of the PTEN tumor suppressor: Membrane association, homodimerization and the role of disordered protein segments

Alex Ladokhin, University of Kansas Medical Center

Endosomal release of diphtheria toxin.
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