Carnegie Mellon University

Abbott Lab

Departments of Biomedical Engineering and Materials Science and Engineering


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Full Citations:

Dewal RS, Yang FT, Baer LA, Vidal P, Hernandez-Saavedra D, Seculov NP, Ghosh A, Noé F, Togliatti O, Hughes L, DeBari MK, West MD, Soroko R, Sternberg H, Malik NN, Puchulu-Campanella E, Wang H, Yan P, Wolfrum C, Abbott RD, Stanford KI. Transplantation of Committed Pre-adipocytes from Brown Adipose Tissue improves Whole-body Glucose Homeostasis. iScience. 2024 Jan 17.

Pre-print: DeBari MK, Johnston EK, Griffin MD, Scott JV, Ilzuka E, Sun W, Webster-Wood VA, Abbott RD. Human subcutaneous adipose tissue variability is driven by TGIF1, ACTA2, adipocyte density, and ancestral history of the patient. Submitted May 31, 2023 to eLife with a preprint available at

Roblin NV, DeBari MK, Shefter SL, Iizuka E, Abbott RD. Development of a More Environmentally Friendly Silk Fibroin Scaffold for Soft Tissue Applications. Journal of Functional Biomaterials. 2023 Apr 18;14(4):230.

Johnston EK, Abbott RD. Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity. Cells. 2023, 12(3), 407.

Johnston EK, Abbott RD. Adipose Tissue Development Relies on Coordinated Extracellular Matrix Remodeling, Angiogenesis, and Adipogenesis. Biomedicines. 202210(9), 2227.

DeBari MK, Ng WH, Griffin MD, Kokai LE, Marra KG, Rubin JP, Ren X, Abbott RD. Engineering a 3D Vascularized Adipose Tissue Construct using a Decellularized Lung Matrix. Biomimetics. 2021, 6(3), 52.

DeBari MK, King C, Altgold TA, Abbott RD. Silk Fibroin as a Green Material. ACS Biomater Sci Eng. 2021 Jul 14.

Kochhar D, DeBari MK, Abbott RD. The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors. Front Bioeng Biotechnol. 2021;9:697981.

DeBari MK, Niu X, Scott JV, Griffin M, Pereira SR, Cook KE, He B, Abbott RD. Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation. Adv Healthc Mater. 2021 Mar.

Abbott RD, LeBlanc S, Melville MC, Moore S, Zapanta CM. Work in progress: Incorporating interactive modules related to cell culture and plasmid design into introduction to biomedical engineering. American Society of Engineering Education. June 2020.

DeBari MK, Abbott RD. Adipose Tissue Fibrosis: Mechanisms, Models, and Importance. International Journal of Molecular Sciences. 2020 Aug; 21(17).

Griffin MD, Pereira SR, DeBari MK, Abbott RD. Mechanisms of Action, Chemical Characteristics, and Model Systems of Obesogens. BMC Biomed Eng. 2020; 2: 6.

Bender R, McCarthy M, Brown T, Bukowska J, Smith S, Abbott RD, Kaplan DL, Williams C, Wade J, Alarcon A, Wu X, Lau F, Gimble JM, Frazier TP. Human Adipose Derived Cells in Two- and Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct. Stem Cells Int. 2020; 2020: 4242130.

McCarthy M, Brown T, Alarcon A, Williams C, Ma M, Wu X, Abbott R, Gimble J, Frazier T. Fat-on-a-Chip models for research and discovery in obesity and its metabolic co-morbidities. Tissue Eng Part B Rev. 2020 Mar 26.

DeBari MK, Keyser MN, Bai MA, Abbott RD3D printing with silk: considerations and applications. Connect Tissue Res. 2018 Dec 17:1-11. 

Lightfoot-Vidal SE, Tamamoto KA, Nguyen H, Abbott RD, Cairns DM, Kaplan DL. 3D Biomaterial Matrix to Support Long Term, Full Thickness, Immuno-competent Human Skin Equivalents. Biomaterials. Accepted April 24, 2018.

Abbott RD, Borowsky FE, Alonzo C, Zieba A, Georgakoudi I, Kaplan DL. Variability in responses observed in human white adipose tissue models. J Tissue Eng Regen Med. 2018 Mar;12(3):840-847.

Wang RY*, Abbott RD*, Zieba A, Borowsky FE, Kaplan DL. Development of a Three-Dimensional Adipose Tissue Model for Studying Embryonic Exposures to Obesogenic Chemicals. Ann Biomed Eng. 2017 Jul;45(7):1807-1818.
* These authors contributed equally to this work.

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL. Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications. Stem Cell Reports. 2016 Sep 13;7(3):557-570.

Abbott RD, Wang RY, Reagan MR, Borowsky FE, Zieba A, Marra KG, Rubin JP, Ghobrial IM, Kaplan DL. The use of silk as a scaffold for mature, sustainable unilocular adipose 3D tissue engineered systems. Adv Healthc Mater. 2016 Jul;5(13):1667-77.

Abbott RD, Kaplan DL. Engineering Biomaterials for Enhanced Tissue Regeneration. Current Stem Cell Reports. 2016 Jun; 2(2):140-146.

Frazier TP, Bowles A, Lee S, Abbott R, Tucker HA, Kaplan D, Wang M, Strong A, Brown Q, He J, Bunnell BA, Gimble JM. Serially transplanted non-pericytic CD146- Adipose Stromal/Stem Cells in silk bioscaffolds regenerate adipose tissue in vivo. Stem Cells. 2016 Apr;34(4):1097-111.

Abbott RD, Kimmerling EP, Cairns DM, Kaplan DL. Silk as a Biomaterial to Support Long-Term Three-Dimensional Tissue Cultures. ACS Appl Mater Interfaces. 2016 Aug 31;8(34):21861-8.

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL. Non-invasive assessments of adipose tissue metabolism in vitro. Ann Biomed Eng. 2016 Mar;44(3):725-32.

Abbott RD, Kaplan DL. Strategies for improving the physiological relevance of human engineered tissues. Trends Biotechnol. 2015 Jul;33(7):401-7.

Abbott RD, Raja WK, Wang RY, Stinson JA, Glettig DL, Burke KA, Kaplan DL. Long term perfusion system supporting adipogenesis. Methods. 2015 Aug;84:84-9.

Tokareva OS, Glettig DL, Abbott RD, Kaplan DL. Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 2015 Oct;103(7):1390-401.

Abbott RD, Kaplan DL. 3D Tissue Engineered Systems for Regenerative Approaches, Drug Discovery, and Toxicity Screening. JoVE. 2014 Oct 16; 5517.

Bellas E, Lo TJ, Fournier EP, Brown JE, Abbott RD, Gil ES, Marra KG, Rubin JP, Leisk GG, Kaplan DL. Injectable Silk Foams for Soft Tissue Regeneration. Adv Healthc Mater. 2015 Feb 18;4(3):452-9.

Abbott RD, Purmessur D, Monsey RD, Brigstock DR, Laudier DM, Iatridis JC. Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3. J Spinal Disord Tech. 2013 May;26(3):E86-94.

Abbott RD, Koptiuch C, Iatridis JC, Howe AK, Badger GJ, Langevin HM. Stress and matrix-responsive cytoskeletal remodeling in fibroblasts. J Cell Physiol. 2013 Jan;228(1):50-7. *Highlight article

Abbott RD, Howe AK, Langevin HM, Iatridis JC. Live free or die: Stretch-induced apoptosis occurs when adaptive reorientation of annulus fibrosus cells is restricted. Biochem Biophys Res Commun. 2012 May 4;421(2):361-6.

Abbott RD, Purmessur D, Monsey RD, Iatridis JC.  Regenerative Potential of TGFβ3+Dex and Notochordal Cell Conditioned Media on Degenerated Human Intervertebral Disc Cells. J Orthop Res. 2012 Mar;30(3):482-8.

Purmessur D, Schek RM, Abbott RD, Ballif BA, Godburn KE, Iatridis JC. Notochordal tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human MSCs. Arthritis Res Ther. 2011 May 31;13(3):R81.

Barbir A, Michalek AJ, Abbott RD, Iatridis JC. Effects of enzymatic digestion on compressive properties of rat intervertebral discs.  J Biomech. 2010 Apr 19;43(6):1067-73.