The Abbott lab at Carnegie Mellon University works at the interface of materials science and regenerative medicine. We investigate how the 3D microenvironment affects tissue development and disease. Our current research focuses on adipose tissue engineering strategies, silk biomaterials and non-invasive tissue assessments to study obesity and it's link to type II diabetes. For more information about what we do, check out our current research projects, publications, and outreach events. To join our team please contact us!
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Professor Abbott is featured on "My Future Tech Podcast!"
5/2023 Prof. Abbott receives an NSF Early CAREER Award titled "3D Printing High Lipid Content Cultivated Meat to Minimize Livestock Environmental Impacts."
4/2023 Prof. Abbott is quoted in the article "What is 3D printed Meat?" on Builtin.
4/2023 Lindsey becomes a New Harvest fellow!
2/2023 Prof. Abbott gives a seminar at the University of Toledo.
1/2023 Lindsey is chosen for the prestigious Presidential Fellowship from CMU!
11/2022 Lindsey gives her first presentation in the "Best Papers Session" at the International Federation of Adipose Tissue Science and Therapeutics Annual Conference.
11/2022 Prof. Abbott provides an “Introduction and Overview of the Field” for the panel “Adipose Tissue Models and Microphysiological Systems” at the International Federation of Adipose Tissue Science and Therapeutics Annual Conference.
11/2022 Prof. Abbott gives a talk and is featured on a panel titled "Spotlight on Inclusive Teaching: Enhancing Diversity, Equity, and Belonging in Course Design and Delivery" at CMU.
10/2022 Prof. Abbott gives a seminar at the University of Maryland titled "Adipose tissue engineering for regenerative applications and disease modelling."
9/2022 The lab was awarded a prize in the Catalyst Phase of the National Academy of Medicine Healthy Longevity Global Competition. This funding will be used to explore tailoring tissue engineering approaches to the aging population.
7/2022 We received notice of award for our NSF grant titled: "Advanced biomanufacturing of scalable, perfusable, pre-vascularized adipose tissues." With this funding, we will expand our research repurposing decellularized lung tissues to create a vascularized adipose tissue graft.
Pre-print: DeBari MK, Johnston EK, Griffin MD, Scott JV, Ilzuka E, Sun W, Webster-Wood VA, Abbott RD. Human subcutaneous adipose tissue variability is driven by TGIF1, ACTA2, adipocyte density, and ancestral history of the patient. Submitted May 31, 2023 to eLife with a preprint available at biorxiv.org.
Roblin NV, DeBari MK, Shefter SL, Iizuka E, Abbott RD. Development of a More Environmentally Friendly Silk Fibroin Scaffold for Soft Tissue Applications. Journal of Functional Biomaterials. 2023 Apr 18;14(4):230.
Johnston EK, Abbott RD. Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity. Cells. 2023, 12(3), 407.
Johnston EK, Abbott RD. Adipose Tissue Development Relies on Coordinated Extracellular Matrix Remodeling, Angiogenesis, and Adipogenesis. Biomedicines. 2022, 10(9), 2227.
DeBari MK, Ng WH, Griffin MD, Kokai LE, Marra KG, Rubin JP, Ren X, Abbott RD. Engineering a 3D Vascularized Adipose Tissue Construct using a Decellularized Lung Matrix. Biomimetics. 2021, 6(3), 52.
DeBari MK, King C, Altgold TA, Abbott RD. Silk Fibroin as a Green Material. ACS Biomater Sci Eng. 2021 Jul 14.
Kochhar D, DeBari MK, Abbott RD. The Materiobiology of Silk: Exploring the Biophysical Influence of Silk Biomaterials on Directing Cellular Behaviors. Front Bioeng Biotechnol. 2021;9:697981.
DeBari MK, Niu X, Scott JV, Griffin M, Pereira SR, Cook KE, He B, Abbott RD. Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation. Adv Healthc Mater. 2021 Mar.
Abbott RD, LeBlanc S, Melville MC, Moore S, Zapanta CM. Work in progress: Incorporating interactive modules related to cell culture and plasmid design into introduction to biomedical engineering. American Society of Engineering Education. June 2020.