supported membrane

Biological Physics

Supramolecular Structures Lab
Lösche/Heinrich Group

Mathias Lösche


admin. assistant: Donna Thomas, 412-268-8367


1976 – 83 Undergraduate School in Physics (Ulm Univ., Germany), M.S. 1983
1983 – 86 Graduate Program in Biophysics (TU Munich, Germany), Ph.D. 1986
1986 – 88 Postdoctoral Researcher in Biophysics (UC San Diego, CA)
1988 – 94 Asst. Professor in Phys. Chem. (Univ. Mainz, Germany), Habilitation 1994
1995 Professorship (tenure) in Exp. Physics (Leipzig University, Germany)

Professional Appointments

2008 – Professor of Biomedical Engineering (by courtesy), Carnegie Mellon
2005 –  Professor of Physics, Carnegie Mellon, Physics Dept., Pittsburgh, PA
2002 – 06 Director, CNBT Consortium, NIST Cntr. f. Neutr. Res., Gaithersburg, MD
2002 – 05 Res. Professor, Dept. of Biophysics, Johns Hopkins, Baltimore, MD
1998 – 02 Head, Biomembrane Physics Group, Leipzig University, Germany
1994 – 05 Assoc. Prof. of Physics, Exp. Phys., Leipzig University, Germany
1988 – 94 Assistant Professor in Physical Chemistry, Mainz University, Germany
1986 – 88 Post-doctoral research fellow, Biophysics Dept, UCSD, La Jolla, CA


Recent Publications

P. Cizas, R. Budvytyte, R. Morkuniene, R. Moldovan, M. Broccio, M. Lösche, G. Niaura, G. Valincius, and V. Borutaite, Size-dependent neurotoxicity of β-amyloid oligomers, Arch. Biochem. Biophys. 496 (2010), 84 - 92.
ABB Website

S. Shenoy, R. Moldovan, J. Fitzpatrick, D. J. Vanderah, M. Deserno, and M. Lösche, In-plane homogeneity and lipid dynamics in tethered Bilayer Lipid Membranes (tBLMs), Soft Matter 6 (2010), 1263 - 1274.
Soft Matter Website

M. B. Smith, D. J. McGillivray, J. Genzer, M. Lösche, and P. K. Kilpatrick, Neutron reflectometry of peptide-incorporated suported hybrid bilayers, Soft Matter 5 (2010), 862 - 865.
Soft Matter Website

S. A. Holt, A. P. Le Brun, C. F. Majkrzak, D. J. McGillivray, F. Heinrich, M. Lösche, and J. H. Lakey, An ion channel containing model membrane: Structural determination by magnetic contrast variation neutron reflectometry, Soft Matter 5 (2009), 2576 - 2586.
Soft Matter Website

F. Heinrich, T. Ng, D. J. Vanderah, P. Shekhar, M. Mihailescu, H. Nanda, and M. Lösche, A new lipid anchor for sparsely-tethered bilayer lipid membranes, Langmuir 25 (2009), 4219 - 4229.
Langmuir Website

D. J. McGillivray, G. Valincius, F. Heinrich, J. W. F. Robertson, D. J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Lösche, and J. J. Kasianowicz, Structure of functional Staphylococcus aureus α-hemolysin channels in tethered bilayer lipid membranes, Biophys. J. 96 (2009), 1547 - 1553. BJ Website

G. Valincius, F. Heinrich, R. Budvytyte, D. J. Vanderah, D. J. McGillivray, Y. Sokolov, J. E. Hall, and M. Lösche, Soluble amyloid β oligomers affect dielectric membrane properties by bilayer insertion and domain formation: Implications for cell toxicity, Biophys. J. 95 (2008), 4845 – 4861. BJ Website / download BioFast preprint / download supplement

D. J. McGillivray, G. Valincius, D. J. Vanderah, W. Febo-Ayala, J. T. Woodward, F. Heinrich, J. J. Kasianowicz, and M. Lösche, Molecular-scale structural and functional characterization of sparsely tethered bilayer membranes, Biointerphases 2 (2007), 21 – 33. download paper / download supplement

J. Pittler, W. Bu, D. Vaknin, A. Travesset, D. J. McGillivray, and M. Lösche, Charge inversion at minute electrolyte concentrations, Phys. Rev. Lett. 97 (2006), 046102.

J. A. Dura, D. J. Pierce, C. F. Majkrzak, N. Maliszewskyj, D. J. McGillivray, M. Lösche, K. V. O’Donovan, M. Michailescu, U. A. Perez-Salas, D. L. Worcester, and S. H. White, AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences, Rev. Sci. Instrum. 77 (2006), 074301.

Full list of publications

Short CV for Mathias Lösche