supported membrane

Biological Physics

Supramolecular Structures Lab
Lösche/Heinrich Group

www.cmu.edu
 
     

Frank Heinrich

 

bild

Education

Universität Leipzig, Leipzig, Germany
May 2005 Dissertation (Dr. rer. nat.) in physics

Positions


June 2005 – December 2005
Postdoctoral research scientist, Johns Hopkins University, Baltimore January

2006 – 2008
Postdoctoral research scientist, Carnegie Mellon University, Pittsburgh

2008 –
Staff Member at the NIST Center for Neutron Research

2008 –
Research Scientist at the CMU Dept. of Physics

Publications

  • S. A. Holt, A. P. Le Brun, C. F. Majkrzak, D. J. McGillivray, F. Heinrich, M. Lösche, and J. H. Lakey, An ion channel containing model membrane: Structural determination by magnetic contrast variation neutron reflectometry, Soft Matter 5:2576 (2009).
  • F. Heinrich, T. Ng, D. J. Vanderah, P. Shekhar, M. Mihailescu, H. Nanda, and M. Lösche, A new lipid anchor for sparsely-tethered bilayer lipid membranes, Langmuir 25:4219 (2009).
  • D. J. McGillivray, G. Valincius, F. Heinrich, J. W. F. Robertson, D. J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Lösche, and J. J. Kasianowicz, Structure of functional Staphylococcus aureus α-hemolysin channels in tethered bilayer lipid membranes, Biophys. J. 96:1547 (2009).
  • W. Knoll, R. Naumann, M. Friedrich, J. W. F. Robertson, M. Lösche, F. Heinrich, D. J. McGil-livray, B. Schuster, P. C. Gufler, D. Pum, and U. B. Sleytr, Solid supported lipid membranes: New concepts for the biomimetic functionalization of solid surfaces, Biointerphases 3:FA125 (2008).
  • G. Valincius, F. Heinrich, R. Budvytyte, D. J. Vanderah, Y. Sokolov, J. E. Hall, and M. Lösche, Soluble amyloid β oligomers affect dielectric membrane properties by bilayer insertion and domain formation: Implications for cell toxicity, Biophys. J. 95:4845 (2008).
  • D. J. McGillivray, G. Valincius, D. J. Vanderah, W. Febo-Ayala, J. T. Woodward, F. Heinrich, J. J. Kasianowicz, and M. Lösche, Molecular-scale structural and functional characterization of sparsely tethered bilayer lipid membranes, Biointerphases 2:21 (2007).
  • J. Grybos, M. Marszalek, M. Lekka, F. Heinrich, W. Tröger, PAC studies of BSA conformational changes, Hyperfine Interactions 159:323 (2004).
  • F. Heinrich, T. Butz, Are LCAO-MO models useful estimators for electric field gradients in simple molecules?, Hyperfine Interactions 158:71 (2004).
  • Frank Heinrich, Bernd Ctortecka, Wolfgang Tröger, The Electric Field Gradient of 111Ag in Macrocyclic Crown Thioethers, Hyperfine Interactions 158:79 (2004).
  • S. Friedemann, F. Heinrich, H. Haas, W. Tröger, The nuclear quadrupole interaction of 204mPb in lead oxides, Hyperfine Interactions 159:313 (2004).

Research Support

Grant Number: 70NANB8H8009
PI: Prof. Mathias Lösche
Period of support: 05/2008 – 04/2013
Funding source: Department of Commerce MSE program

Title of grant:
Ultra-high resolution neutron reflection metrology for the analysis of protein-membrane interactions

Description of research goals:
This project is designed to push the limits of resolution in biophysical studies of artificial lipid membrane systems for biomedical research. Technical development implemented in the framework of the NCNR Expansion Initiative will enable a leap in our capabilities for structural characterization of such systems. To date, the NCNR is already among the world leaders in neutron reflection (NR) metrology for biomolecular, polymeric and magnetic thin films research. The design and commissioning of the revolutionary Chromatic Analysis Neutron Diffractometer Or Reflectometer (CANDOR) provides the basis for an enhancement of neutron flux further by about 2 orders of magnitude. Thereby, this new instrument will challenge the world’s most powerful NR instrumentation at ORNL-SNS and ILL (Grenoble). This proposal lays out a systematic plan to utilize these new capabilities in a decisive sector of application, i.e., biomedical research.