Assistant Professor of Biological Sciences & Co-Director, M.S. in Computational Biology Program
ResearchResearch in the McManus lab focuses on understanding the genetic and molecular mechanisms of gene regulation. Gene expression is regulated at multiple levels, including transcription, splicing, and translation of mRNA, and mRNA and protein turnover. RNA folds into complex structures that could play an important role in gene regulation. We use high-throughput sequencing to identify changes in transcription, mRNA structure, and translation to identify links between the processes that control gene expression.
May, G.E.; Olson, S.; McManus, C.J.; Graveley, B.R. Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster. RNA 2011, 17(2):222-229.
McManus, C.J.; Graveley, B.R. RNA Structure and the mechanisms of alternative splicing. Curr Opin Genet Dev 2011, 21(4):373-9.
McManus, C.J.; Coolon, J.D.; Duff, M.O.; Eipper-Mains, J.; Graveley, B.R.; Wittkopp, P.J. Regulatory Divergence in Drosophila revealed by mRNA-seq. Genome Res 2010, 20(6):816-825.
McManus, C.J.; Duff, M.O.; Eipper-Mains, J.; Graveley, B.R. Global analysis of trans-splicing in Drosophila. Proc Natl Acad Sci USA 2010, 107(29):12975-12979.
McManus, C.J.; Graveley, B.R. Getting the message out. Mol Cell. 2008, 31(1):4-6.