supported membrane

Biological Physics

Supramolecular Structures Lab
Lösche/Heinrich Group

Mathias Lösche


admin. assistant: Amanda Bodnar, 412-268-8367

Want to chat by e-mail w/o being overheard?
Download my public GPG key


1976 – 83 Undergraduate School in Physics (Ulm Univ., Germany), M.S. 1983
1983 – 86 Graduate Program in Biophysics (TU Munich, Germany), Ph.D. 1986
1986 – 88 Postdoctoral Researcher in Biophysics (UC San Diego, CA)
1988 – 94 Asst. Professor in Phys. Chem. (Univ. Mainz, Germany), Habilitation 1994
1995 Professorship (tenure) in Exp. Physics (Leipzig University, Germany)

Professional Appointments

2008 – Professor of Biomedical Engineering (by courtesy), Carnegie Mellon
2005 –  Professor of Physics, Carnegie Mellon, Physics Dept., Pittsburgh, PA
2002 – 06 Director, CNBT Consortium, NIST Cntr. f. Neutr. Res., Gaithersburg, MD
2002 – 05 Res. Professor, Dept. of Biophysics, Johns Hopkins, Baltimore, MD
1998 – 02 Head, Biomembrane Physics Group, Leipzig University, Germany
1994 – 05 Assoc. Prof. of Physics, Exp. Phys., Leipzig University, Germany
1988 – 94 Assistant Professor in Physical Chemistry, Mainz University, Germany
1986 – 88 Post-doctoral research fellow, Biophysics Dept, UCSD, La Jolla, CA


Recent Publications

H. Nanda, F. Heinrich, and M. Lösche, Membrane association of the PTEN tumor suppressor: Neutron scattering and MD simulations reveal the structure of protein-membrane complexes, Methods (2015), in press.
download accepted manuscript

A. Kalinowski, P. N. Yaron, Z. Qin, S. Shenoy, M. J. Buehler, M. Lösche, and K. N. Dahl, Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson–Gilford progeria syndrome, Biophys. Chem. 195 (2014), 43 - 38.
download paper

R. Pulido, J. T. Barata, A. Carracedo, V. J. Sid, I. D. Chin-Sang, V. Davé, J. den Hertog, P. Devreotes, B. Eickholt, C. Eng, F. B. Furnari, M. M. Georgescu, A. Gericke, B. Hopkins, X. Jiang, S. R. Lee, M. Lösche, P. Malaney, X. Matias-Guiu, M. Molina, P. P. Pandolfi, R. Parsons, P. Pinton, C. Rivas, R. M. Rocha, M. S. Rodriguez, A. H. Ross, A. Serrano, V. Stambolic, B. Stiles, A. Suzuki, S. S. Tan, N. K. Tonks, L. C. Trotman, N. Wolff, R. Woscholski, H. Wu, and N. R. Leslie, A unified nomenclature and amino acid numbering for human PTEN, Sci. Signal. 7 (2014), pe15.

F. Heinrich and M. Lösche, Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes, Biochim. Biophys. Acta 1838 (2014), 2341 - 2349.
download paper

F. Heinrich, H. Nanda, H. Z. Goh, C. Bachert, M. Lösche, and A. D. Linstedt, Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering, J. Biol. Chem. 289 (2014), 9683 - 9691.
download paper

A. Gericke, N. R. Leslie, M. Lösche, and A. H. Ross, PI(4,5)P2-mediated cell signaling: Emerging principles and PTEN as a paradigm for regulatory mechanism, Ch. 6 in: Advances in Experimental Medicine and Biology, Vol. 991, Lipid-Mediated Membrane Targeting of Proteins, Ed.: D. G. S. Capelluto (Springer, New York, 2013), 85 - 104.
download paper

A. Kalinowski, Z. Qin, K. Coffey, R. Kodali, M. J. Buehler, M. Lösche, K. N. Dahl, Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association, Biophys. J. 104 (2013), 2246 - 2253.
download paper

R. Budvytyte, G. Valincius, G. Niaura, V. Voiciuk, M. Mickevicius, H. Chapman, H.-Z. Goh, P. Shekhar, F. Heinrich, S. Shenoy, M. Lösche, and D. J. Vanderah, Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules, Langmuir 29 (2013), 8645 - 8656.
download paper

S. Shenoy, H. Nanda and M. Lösche, Membrane association of the PTEN tumor suppressor: Electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail, J. Struct. Biol. 180 (2012), 394 - 408.
download paper

Goh H. Z., C. Tan, M. Deserno, F. Lanni, and M. Lösche, Hemifusion of giant unilamellar vesicles with planar hydrophobic surfaces: A fluorescence microscopy study, Soft Matter 8 (2012), 10877 - 10886.
download paper

S. Shenoy, P. Shekhar, F. Heinrich, M.-C. Daou, A. Gericke, A. H. Ross, and M. Lösche, Membrane association of the PTEN tumor suppressor: Molecular details of the protein-membrane complex from SPR binding studies and neutron reflection, PLoS One 7 (2012), e32591.
download paper

M. I. Lioudyno, M. Broccio, Y. Sokolov, S. Rasool, J. Wu, M. T. Alkire, V. Liu, J. A. Kozak, P. R. Dennison, C. G. Glabe, M. Lösche, and J. E. Hall, Effect of synthetic Aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance, PLoS One 7 (2012), e35090.
download paper

P. N. Yaron, B. D. Holt, P. A. Short, M. Lösche, M. F. Islam, and K. N. Dahl, Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration, J. Nanobiotechn. 9 (2011), 45-1 - 15.
download paper

P. Shekhar, H. Nanda, M Lösche, and F. Heinrich, Continuous distribution model for the investigation of complex molecular architectures near interfaces with scattering techniques, J. Appl. Phys. 110 (2011), 102216-1 - 12.
download paper

H. Nanda, S. Datta, F. Heinrich, M. Lösche, J. E. Curtis, A. Rein, S. Krueger, Electrostatic interactions and binding orientation of HIV-1 matrix, studied by neutron reflectivity, Biophys. J. 99 (2010), 2516 - 2524.
BJ Website / download paper / download supplement

P. Cizas, R. Budvytyte, R. Morkuniene, R. Moldovan, M. Broccio, M. Lösche, G. Niaura, G. Valincius, and V. Borutaite, Size-dependent neurotoxicity of β-amyloid oligomers, Arch. Biochem. Biophys. 496 (2010), 84 - 92.
ABB Website

S. Shenoy, R. Moldovan, J. Fitzpatrick, D. J. Vanderah, M. Deserno, and M. Lösche, In-plane homogeneity and lipid dynamics in tethered Bilayer Lipid Membranes (tBLMs), Soft Matter 6 (2010), 1263 - 1274.
Soft Matter Website

M. B. Smith, D. J. McGillivray, J. Genzer, M. Lösche, and P. K. Kilpatrick, Neutron reflectometry of peptide-incorporated suported hybrid bilayers, Soft Matter 5 (2010), 862 - 865.
Soft Matter Website

S. A. Holt, A. P. Le Brun, C. F. Majkrzak, D. J. McGillivray, F. Heinrich, M. Lösche, and J. H. Lakey, An ion channel containing model membrane: Structural determination by magnetic contrast variation neutron reflectometry, Soft Matter 5 (2009), 2576 - 2586.
Soft Matter Website

F. Heinrich, T. Ng, D. J. Vanderah, P. Shekhar, M. Mihailescu, H. Nanda, and M. Lösche, A new lipid anchor for sparsely-tethered bilayer lipid membranes, Langmuir 25 (2009), 4219 - 4229.
Langmuir Website

D. J. McGillivray, G. Valincius, F. Heinrich, J. W. F. Robertson, D. J. Vanderah, W. Febo-Ayala, I. Ignatjev, M. Lösche, and J. J. Kasianowicz, Structure of functional Staphylococcus aureus α-hemolysin channels in tethered bilayer lipid membranes, Biophys. J. 96 (2009), 1547 - 1553. BJ Website

G. Valincius, F. Heinrich, R. Budvytyte, D. J. Vanderah, D. J. McGillivray, Y. Sokolov, J. E. Hall, and M. Lösche, Soluble amyloid β oligomers affect dielectric membrane properties by bilayer insertion and domain formation: Implications for cell toxicity, Biophys. J. 95 (2008), 4845 – 4861. BJ Website / download BioFast preprint / download supplement

D. J. McGillivray, G. Valincius, D. J. Vanderah, W. Febo-Ayala, J. T. Woodward, F. Heinrich, J. J. Kasianowicz, and M. Lösche, Molecular-scale structural and functional characterization of sparsely tethered bilayer membranes, Biointerphases 2 (2007), 21 – 33. download paper / download supplement

J. Pittler, W. Bu, D. Vaknin, A. Travesset, D. J. McGillivray, and M. Lösche, Charge inversion at minute electrolyte concentrations, Phys. Rev. Lett. 97 (2006), 046102.

J. A. Dura, D. J. Pierce, C. F. Majkrzak, N. Maliszewskyj, D. J. McGillivray, M. Lösche, K. V. O’Donovan, M. Michailescu, U. A. Perez-Salas, D. L. Worcester, and S. H. White, AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences, Rev. Sci. Instrum. 77 (2006), 074301.

Full list of publications

Short CV for Mathias Lösche