Carnegie Mellon University

Department of Physics

Mellon College of Science

Stephanie A. Tristram-Nagle

Research Professor Emerita

Biological Physics Experiment
Wean Hall 6415

lab website 

Prof. Stephanie Tristram-Nagle

Education & Professional Experience

PhD: UC Berkeley (1981)

Professional Societies:
American Physical Society, Biophysical Society, Association for Women in Science, AAAS

Honors and Awards:
Biophysical Society Avanti Award in Lipids (2003)

Curriculum ViTA

Research Professor, Carnegie Mellon University, 2008–16
Associate Research Professor, Carnegie Mellon University, 2005–08
Senior Research Biologist, Carnegie Mellon University, 1998–2005
Research Biologist, Carnegie Mellon University, 1986–98
Post-doctoral Research: Carnegie Mellon University, 1982–86

Research Interests

Stephanie Tristram-Nagle (emerita) actively performs research into lipid membrane structure, properties and thermodynamics. Her lab explores the structure of biological phospholipids, lipid/peptide and lipid/cholesterol mixtures using oriented samples on substrates or large unilamellar vesicles using X-ray diffuse scattering with a Rigaku rotating anode and CCD detector here at CMU, and with synchrotron radiation at the Cornell High Energy Synchorotron Source (CHESS). Her current focus is on the interaction of antimicrobial peptides with bacterial membrane mimics. The X-ray data yield not only structure, such as lipid area and membrane thickness, but also the bending and compression moduli of the membranes. Tristram-Nagle collaborates with MD simulators to compare experimental with simulated results. Her lab also measures lipid volumes with an Anton-Paar 5000M densitometer and D2O-H2O mixtures.


Selected Publications

J. F. Nagle, M. Jablin, S. Tristram-Nagle, Sugar Does Not Affect the Bending and Tilt Moduli of Simple Lipid Bilayers. Chem. Phys. Lipids 196, 76 (2016)

J. F. Nagle, K. Akabori, B. W. Treece, S. Tristram-Nagle, Determination of Mosaicity in Oriented Stacks of Lipid BilayersSoft Matter 12, 1884 (2016)

S. Tristram-Nagle, Use of X-Ray and Neutron Scattering Methods with Volume Measurements to Determine Lipid Bilayer Structure and Number of Water Molecules/Lipid. In Membrane HydrationSubcellular Biochemistry, Vol. 71, pp. 17-43. Ed. E. A. Disalvo, Springer (2015)

Chris Neale, Kun Huang, Angel García, Stephanie Tristram-Nagle, Penetration of HIV-1 Tat47–57 into PC/PE Bilayers Assessed by MD Simulation and X-ray ScatteringMembranes 5, 473 (2015) 

Yunyan Qiu, Jacob Mohin, Chia-Hua Tsai, Stephanie Tristram-Nagle, Roberto R. Gil, Tomasz Kowalewski, Kevin J. T. Noonan, Stille Catalyst-Transfer Polycondensation Using Pd-PEPPSI-IPr for High-Molecular-Weight Regioregular Poly(3-hexylthiophene)Macromolecular Rapid Communications 36, 840 (2015) 

Kiyotaka Akabori, Kun Huang, Bradley W. Treece, Michael S. Jablin, Brian Maranville, Arthur Woll, John F. Nagle, Angel E. Garcia, Stephanie Tristram-Nagle, HIV-1 Tat membrane interactions probed using X-ray and neutron scattering, CD spectroscopy and MD simulationsBiochimica et Biophysica Acta (BBA) - Biomembranes 1838, 3078 (2014)

Alexander L. Boscia, Bradley W. Treece, Dariush Mohammadyani, Judith Klein-Seetharaman, Anthony R. Braun, Tsjerk A. Wassenaar, Beate Klösgen, Stephanie Tristram-Nagle, X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranesChemistry and Physics of Lipids 178, 1 (2014) 

Alexander L. Boscia, Kiyotaka Akabori, Zachary Benamram, Jonathan A. Michel, Michael S. Jablin, Jonathan D. Steckbeck, Ronald C. Montelaro, John F. Nagle, Stephanie Tristram-Nagle, Membrane Structure Correlates to Function of LLP2 on the Cytoplasmic Tail of HIV-1 gp41 ProteinBiophysical Journal 105, 657 (2013) 

Kelsey M. Hallinen, Stephanie Tristram-Nagle, John F. Nagle, Volumetric stability of lipid bilayersPhysical Chemistry Chemical Physics 14, 15452 (2012)

Jianjun Pan, Frederick A. Heberle, Stephanie Tristram-Nagle, Michelle Szymanski, Mary Koepfinger, John Katsaras, Norbert Kučerka, Molecular structures of fluid phase phosphatidylglycerol bilayers as determined by small angle neutron and X-ray scatteringBiochimica et Biophysica Acta (BBA) - Biomembranes 1818, 2135 (2012)

Mohit Raghunathan, Yuriy Zubovski, Richard M. Venable, Richard W. Pastor, John F. Nagle, Stephanie Tristram-Nagle, Structure and Elasticity of Lipid Membranes with Genistein and Daidzein Bioflavinoids Using X-ray Scattering and MD SimulationsThe Journal of Physical Chemistry B 116, 3918 (2012)

Anthony R. Braun, Eva Sevcsik, Pamela Chin, Elizabeth Rhoades, Stephanie Tristram-Nagle, Jonathan N. Sachs, α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in MembranesJournal of the American Chemical Society 134, 2613 (2012)

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ORCID  Researcher ID