Professor of Physics, Professor of Biomedical Engineering; NIST Associate
EducationPh.D., Technical University of Munich
In the past few decades, biology has revolutionalized our understanding of how living matter organizes itself to achieve the most astounding feat on the planet: Create intricate, organized structures that self-replicate and continuously develop further - despite the dictum of entropy which inequitably favors disorder over order. Are living systems therefore somehow miraculously exempt from the laws of Physics? - No, they have "learned" to exploit loopholes in the dictate of entropy in truly stunning ways! Biological Physics is a fascinating branch of "mainstream Physics" that tries to solve the underlying puzzles.
Our work in Experimental Biophysics focuses on the functional, structural and dynamic characterization of biomimetic membranes (that is, artifical and lipid bilayer systems that are simpler than complex biological membranes but capture their fundamental Physics aspects). For example, we use surface-sensitive x-ray and neutron scattering alongside with electrochemical and advanced optical techniques to identify, characterize, and optimize membrane models in which we study the association of proteins with lipid bilayers. Microscopy techniques are used to assess their in-plane fluidity, dynamics, and 2D morphology. With this set of tools, we investigate experimentally the physical principles of membrane self-assembly and functionality. We also study the molecular origins of disease, through quantification of the membrane interactions of proteins and peptides, such as neurotransmitters, toxins or tumor suppressor proteins. These studies contribute to a deeper understanding of disease mechanisms, cellular attack through pathogens and the self-assembly of viral particles, such as HIV, in affected cells.
- Yang Shen, Marilia Barros, Tarek Vennemann, D, Travis Gallagher, Yizhou Yin, Sara B. Linden, Ryan D. Heselpoth, Dennis J. Spencer, David M. Donovan, John Moult, Vincent A. Fischetti, Frank Heinrich, Mathias Lösche, and Daniel C. Nelson, PlyC, a bacteriophage endolysin that is internalized by epithelial cells and retains bacteriolytic activity against intracellular streptococci, eLife 5, e13152 (2016)
- Marilia Barros, Frank Heinrich, Siddhartha A. K. Datta, Alan Rein, Ioannis Karageorgos, Hirsh Nanda, Mathias Lösche, Membrane binding of HIV-1 matrix protein: Dependence on bilayer composition and protein lipidation, J. Virol. 90, 4544 (2016)
- Robert A. Dick, Marilia Barros, Danni Jin, Mathias Lösche, Volker M. Vogt, Membrane binding of the Rous sarcoma virus Gag protein is cooperative and dependent on the SPA domain, J. Virol. 90, 2473 (2016)
- Frank Heinrich, Srinivas Chakravarthy, Hirsh Nanda, Antonella Papa, Pier Paolo Pandolfi, Alonzo H. Ross, Rakesh K. Harishchandra, Arne Gericke, Mathias Lösche, The PTEN tumor suppressor forms homodimers in solution, Structure 23, 1952 (2015)
- Frank Heinrich, Mathias Lösche, Zooming in on disordered systems: Neutron reflection studies of proteins associated with fluid membranes, Biochim. Biophys. Acta 1838, 2341 (2014)
- Rima Budvytyte, Gintaras Valincius, Gediminas Niaura, Vladislava Voiciuk, Mindaugas Mickevicius, Hilary Chapman, Haw-Zan Goh, Prabhanshu Shekhar, Frank Heinrich, Sishharth S. Shenoy, Mathias Lösche, David J. Vanderah, Structure and properties of tethered bilayer lipid membranes with unsaturated anchor molecules, Langmuir 29, 8645 (2013)
- Siddharth S. Shenoy, Hirsh Nanda, Mathias Lösche, Membrane association of the PTEN tumor suppressor: Electrostatic interaction with phosphatidylserine-containing bilayers and regulatory role of the C-terminal tail, J. Struct. Biol. 180, 394 (2012)
- Prabhanshu Shekhar, Hirsh Nanda, Mathias Lösche, Frank Heinrich, Continuous distribution model for the investigation of complex molecular architectures near interfaces with scattering techniques, J. Appl. Phys. 110, 102216 (2011)
- Peter N Yaron, Brian D Holt, Philip A Short, Mathias Lösche, Mohammad F Islam, Kris Dahl, Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration, J. Nanobiotech. 9, 45 (2011)
- Stephen A. Holt, Anton P. Le Brun, Charles F. Majkrzak, Duncan J. McGillivray, Frank Heinrich, Mathias Lösche, Jeremy H. Lakey, An ion-channel-containing model membrane: structural determination by magnetic contrast neutron reflectometry, Soft Matter 5, 2576 (2009)