Markus Deserno-Dept of Physics - Carnegie Mellon University

Markus Deserno

Associate Professor, Physics

Office: Wean Hall 6319
Phone: 412-268-4401
Fax: 412-681-0648

Education

Ph.D., Max-Planck-Institute for Polymer Research

Research

Biological systems belong to the most fascinating and mysterious entities to be found in our universe, and yet their functioning ultimately rests entirely on very well known laws of nature. In order to understand how biological systems work we do not need to discover previously unknown bits of physics and chemistry; the task is rather to piece the puzzle together and learn how simple laws can explain complex phenomena. Biological Physics is thus a synthetic science, much like Statistical Physics, from whose arsenal of methods it frequently and heavily borrows.

In my research I look at various exciting problems in Biological Physics, dealing, among other things, with lipid membranes, proteins, viruses, or DNA. In all cases I am most interested in phenomena that occur on length scales larger than atomic resolution (i.e., I'm not looking at the specific chemistry) but smaller than whole cells. On these scales many fundamental physical concepts have a big impact on biology, among them thermal fluctuations, cooperativity, self-assembly, or elasticity. For instance, due to their surfactant-like nature individual lipid molecules in an aqueous environment spontaneously aggregate into membranes, which span laterally over scales many orders of magnitude larger than their thickness. These quasi-two-dimensional fluid surfaces resist bending, a continuum elastic concept, but since the associated moduli are only about one order of magnitude bigger than thermal energy, membranes can exhibit large thermal undulations that can very substantially affect their behavior.

In my research I use both theoretical and computational techniques. On the theoretical side I use tools from continuum elastic descriptions, differential geometry, density functional theories, and statistical thermodynamics. On the computational side I mostly use what is known as "coarse-grained simulations". This means that the physical system is not represented on the computer in atomic detail. Rather, a much smaller number of degrees of freedom is used to describe a lipid or a protein. Giving up chemical resolution implies that questions dependent on it cannot be addressed. However, on sufficiently large length scales such detail hardly matters, and the physical properties relevant at this scale, for instance the bending rigidity of a membrane, can be accounted for very appropriately.

The benefits to be reaped from these simplified theoretical and computational descriptions are twofold: First, one can study much larger systems on much longer time scales with much better statistics, and thus access a new arena for physical questions. Second, if a highly simplified model still manages to capture key aspects of the situation at hand, chances are that we have identified the key bits of physics that matter. In other words, we might just have understood something deep about our system that would not be immediately obvious when looking at the original hugely more complicated situation.

Selected Publications

  • Christoph Globisch, Venkatramanan Krishnamani, Markus Deserno, Christine Peter, Optimization of an Elastic Network Augmented Coarse Grained Model to Study CCMV Capsid Deformation, PLoS ONE 8(4), e60582 (2013)
  • Mingyang Hu, Djurre H. de Jong, Siewert J. Marrink, Markus Deserno, Gaussian curvature elasticity determined from global shape transformations and local stress distributions: a comparative study using the MARTINI model, Faraday Discussions 161, 365 (2012)
  • Goh Haw Zan, Cheemeng Tan, Markus Deserno, Frederick Lanni, Mathias Lösche, Hemifusion of giant unilamellar vesicles with planar hydrophobic surfaces: a fluorescence microscopy study, Soft Matter 8, 10877 (2012)
  • Mingyang Hu, John J. Briguglio, Markus Deserno, Determining the Gaussian Curvature Modulus of Lipid Membranes in Simulations, Biophysical Journal 102, 1403 (2012)
  • Tristan Bereau, Christoph Globisch, Markus Deserno, Christine Peter, Coarse-Grained and Atomistic Simulations of the Salt-Stable Cowpea Chlorotic Mottle Virus (SS-CCMV) Subunit 26–49: β-Barrel Stability of the Hexamer and Pentamer Geometries, Journal of Chemical Theory and Computation 8, 3750 (2012)
  • Goh Haw Zan, Cheemeng Tan, Markus Deserno, Frederick Lanni, Mathias Lösche, Hemifusion of giant unilamellar vesicles with planar hydrophobic surfaces: a fluorescence microscopy study, Soft Matter 8, 10877 (2012)
  • C. Yolcu, I. Z. Rothstein, M. Deserno, Effective field theory approach to Casimir interactions on soft matter surfaces, EPL (Europhysics Letters) 96, 20003 (2011)
  • Benedict J. Reynwar, Markus Deserno, Membrane-mediated interactions between circular particles in the strongly curved regime, Soft Matter 7, 8567 (2011)
  • Tristan Bereau, Michael Bachmann, Markus Deserno, Interplay between Secondary and Tertiary Structure Formation in Protein Folding Cooperativity, Journal of the American Chemical Society 132, 13129 (2010)
  • Siddharth Shenoy, Radu Moldovan, James Fitzpatrick, David J. Vanderah, Markus Deserno, Mathias Lösche, In-plane homogeneity and lipid dynamics in tethered bilayer lipid membranes (tBLMs), Soft Matter 6, 1263 (2010)
  • Zun-Jing Wang, Markus Deserno, A Systematically Coarse-Grained Solvent-Free Model for Quantitative Phospholipid Bilayer Simulations, The Journal of Physical Chemistry B 114, 11207 (2010)
  • Markus Deserno, Mesoscopic Membrane Physics: Concepts, Simulations, and Selected Applications, Macromolecular Rapid Communications 30, 752 (2009)
  • Teemu Murtola, Alex Bunker, Ilpo Vattulainen, Markus Deserno, Mikko Karttunen, Multiscale modeling of emergent materials: biological and soft matter, Physical Chemistry Chemical Physics 11, 1869 (2009)
  • Tristan Bereau, Markus Deserno, Generic coarse-grained model for protein folding and aggregation, The Journal of Chemical Physics 130, 235106 (2009)
  • Benedict J. Reynwar, Gregoria Illya, Vagelis A. Harmandaris, Martin M. Müller, Kurt Kremer, Markus Deserno, Aggregation and vesiculation of membrane proteins by curvature-mediated interactions, Nature 447, 461 (2007)
  • Ira Cooke, Kurt Kremer, Markus Deserno, Tunable generic model for fluid bilayer membranes, Physical Review E 72, 011506 (2005)