Carnegie Mellon University ———
Mellon College of Science  ›  Computational Cancer Research  ›  Faculty  ›  Siyang Zheng

Siyang Zheng

Associate Professor, Electrical and Computer Engineering Biomedical Engineering

Address:
Scott Hall 4N211
Electrical and Computer Engineering, CE
Carnegie Mellon University
5000 Forbes Avenue
Pittsburgh, PA 15213

Email

Siyang Zheng
We have been developing micro/nano technologies for cancer diagnosis and therapeutics with a multidisciplinary approach. The goals are making the technologies available for research and clinical translation. On the diagnostic side, we have invented several devices and materials to enable liquid biopsy for minimal invasive cancer diagnosis by developing technologies to (1) isolate and analyze circulating tumor cells (CTCs) from peripheral blood of cancer patients; and (2) isolate extracellular vesicles (EVs) from blood plasma and other body fluids of cancer patients and detect cancer associated biomarkers. On the therapeutic side, we are interested in developing nanomaterials and/or nanomaterial-integrated microdevices for new cancer therapies. For example, we developed a nanoparticle platform to deliver therapeutic proteins into cancer cells systemically. We are exploring EVs as an active agent to deliver drugs and/or enhance therapeutic efficacy.

Highlighted Publications

G. Cheng, X. Han, and S.-Y. Zheng, Magnetically driven nanotransporter assisted intracellular delivery and autonomous release of proteins. ACS Applied Materials & Interfaces, 12: 41096-41104, (2020).

Y. Wan, M. Maurer, H.-Z. He, Y.-Q. Xia, W.-L. Zhang, S.-J. Hao, N. S. Yee, and S.-Y. Zheng, Enrichment of Extracellular Vesicles with Lipid Nanoprobe Functionalized Nanostructured Silica. Lab on a Chip, 19(14): 2346-2355, (2019).

Y. Wan, B. Liu, H. Lei, B. Zhang, Y. Wang, H. Huang, S. Chen, Y. Feng, L. Zhu, Y. Gu, Q. Zhang, H. Ma, and S.-Y. Zheng, Nanoscale extracellular vesicle-derived DNA is superior to circulating cell free DNA for mutation detection in early-stage non-small cell lung cancer. Annals of Oncology, 29(12): 2379-2383, (2018).

Y. Xia, Y. Wan, S. Hao, M. Nisic, R. A. Harouaka, Y. Chen, X. Zou, and S.-Y. Zheng, Nucleus of circulating tumor cell determines its translocation through biomimetic microconstrictions and its physical enrichment by microfiltration. Small, 14(44): e1802899, (2018).

W. Li, Z. Wang, S. Hao, L. Sun, M. Nisic, G. Cheng, C. Zhu, Y. Wan, L. Ha, and S.-Y. Zheng, Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. Nanoscale, 10, 3744-3752, (2018).

W. Li, L. Sun, Y. Xia, S.-J. Hao, G. Cheng, Z. Wang, Y. Wan, C. Zhu, H. He, and S.-Y. Zheng, Pre-occupation of empty carriers decreases endo/lysosome escape and reduces the protein delivery efficiency of mesoporous silica nanoparticles. ACS Applied Materials & Interfaces, 10, 5340-5347, (2018).

S.-J. Hao, Y. Wan, Y.-Q. Xia, X. Zou, and S.-Y. Zheng, Size-based separation methods of circulating tumor cells. Advanced Drug Delivery Reviews, 125, 3-20, (2018).

S. Hao, L. Ha, G. Cheng, Y. Wan, Y. Xia, D. M. Sosnoski, A. M. Mastro, and S.-Y. Zheng, A spontaneous 3D bone-on-a-chip for bone metastasis study of breast cancer cells. Small, 14, 1702787, (2018).

Y. Wan, L. Wang, C. Zhu, Q. Zheng, G. Wang, J. Tong, Y. Fang, Y.-Q. Xia, G. Cheng, X. He, and S.-Y. Zheng, Aptamer conjugated extracellular nanovesicles for in vivo targeted drug delivery. Cancer Research, 78, 798-808, (2018).

W. Li, Z. Wang, S.-J. Hao, H. He, Y. Wan, C. Zhu, L. Sun, G. Cheng, & S.-Y. Zheng, Mitochondria-targeting polydopamine nanoparticles to deliver doxorubicin for overcoming drug resistance. ACS Applied Materials & Interfaces, 9, 16793–16802, (2017).

Y.-T. Yeh, R. A. Harouaka, & S.-Y. Zheng, Evaluating a novel dimensional reduction approach for mechanical fractionation of cells using a tandem flexible micro spring array (tFMSA). Lab on a Chip, 17 (4), 691-701 (2017).

M.-D. Zhou, S. Hao, A. J. Williams†, R. A. Harouaka, B. Schrand, S. Rawal, Z. Ao, R. Brennaman, E. Gilboa, B. Lu, S. Wang, J. Zhu, R. Datar, R. Cote, Y.-C. Tai*, and S.-Y. Zheng*, Separable bilayer microfiltration device for viable label-free enrichment of circulating tumour cells, Scientific Reports, 4: 7392, 1-10, (2014).

R. A. Harouaka, Z. Kang, S.-Y. Zheng, L. Cao, Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications, Pharmacology and Therapeutics, vol.141, pp. 209-221, (2014).

R. A. Harouaka, M. Nisic, S.-Y. Zheng, Circulating tumor cell enrichment based on physical properties, Journal of Laboratory Automation, vol. 18, pp. 455-468, (2013).

S. Zheng, H. K. Lin, B. Lu, A. Williams, R. H. Datar, R. J. Cote RJ, Y.-C. Tai, 3D Microfilter Device for Viable Circulating Tumor Cell (CTC) Enrichment from Blood, Biomedical Microdevices, vol.13, pp. 203-213, (2011).

H. K. Lin*, S. Zheng*, A. J. Williams, M. Balic, S. Groshen, H. I. Scher, M. Fleisher, W. Stadler, R. H. Datar, Y.-C. Tai, R. J. Cote, Portable filter-based microdevice for detection and characterization of circulating tumor cells, Clinical Cancer Research, vol 16, pp. 5011-5018, (2010).

S. Zheng, H. Lin, J.-Q. Liu, M. Balic, R. Datar, R. J. Cote, and Y.-C. Tai, Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells, Journal of Chromatography A, vol. 1162, pp. 154-161, (2007).

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