Projects-Engineering Research Accelerator - Carnegie Mellon University

Bioengineering Technologies Projects

Tissue Engineering Technologies

BioprintingPhil Campbell, Lee Weiss
Inkjet-based bioprinted patterns of growth factors and other signaling molecules are used to drive stem cell populations toward multiple fates, in vitro and in vivo, in spatial registration to these patterns. The printed patterns can be used for basic biological discovery, and eventually patterns could also be used directly as tissue engineered therapies.

Non-Invasive Imaging of Tissue Engineered Construct Remodeling In VivoPhil Campbell, Marcel Bruchez, and Byron Ballou
Fluorescent toolsets are being developed to non-invasively follow the fate of implanted stem cells and remodeling of implanted scaffolds in animals. The goal is to use these toolsets for biological discovery to aid therapy design.

Computer Vision-Based Cell TrackingPhil Campbell, Lee Weiss, and Takeo Kanade, in collaboration with Intel Corporation
A real-time, automated computer vision-based cell tracking system is being developed to measure the spatiotemporal histories of each individual cell within populations of cells in vitro. The goals are to use this system to enable high-throughout analysis of cell fates in response to microenvironmental niches, and for on-line process monitoring of stem cell expansion cultures.

Biodegradable ElectronicsLee Weiss, Phil Campbell, Jeyanandh Paramesh, and Gary Fedder
This is a new, exploratory initiative where electronic circuits embedded in scaffold materials are being developed that will degrade in and be resorbed by the body (including the electronics) after they are no longer needed. Power and data communication is provided by RF telemetry. The initial target application is an implantable electrical stimulator to stimulate bone tissue growth and repair.

Blood Plasma-Based PlasticsPhil Campbell and Lee Weiss
Biodegradable plastics are being made from platelet-rich plasma. These implantable bioactive materials are being investigated for use in the treatment of a wide range of injuries. This technology was recently been spun-off into a start-up company Carmell Therapeutics.

Cardiovascular Biomechanics and Medical Devices

Quantification of Regional Cardiovascular Deformation from Dynamic CT DataIsabella Verdinelli, Artur Dubrawski
Combining a tag-less tracking approach and a probabilistic method to optimize the position of the tracked points at each consequent cardiac phase, we compute deformation maps for heart and vascular structures from dynamic CT images.

Mechanics of the Left Atrium: Implications for Atrial Fibrillation
Non linear dynamic models for the left atrium, obtained from high speed CT images, are used to investigate the effects of mechanical stresses on atrium function.

Stress-Modulated Remodeling of a Non-Homogeneous Body
The stress–modulated remodeling of a vessel wall when local variations in the mechanical properties of the material exist is studied by means of a numerical approach.

Biomechanical Studies of Abdominal Aortic Aneurysm Weakening
The risk of rupture of abdominal aortic aneurysms and its progression with time is studied by means of a novel risk of rupture index.

BioMEMs

Microminiature, Implantable, Wireless Strain Gage ArraysGary Fedder, Phil Campbell, Lee Weiss
In particular, intarosseous (embedded within bone) sensors are being developing for a range of application, including: as a tool to gain new knowledge about bone regeneration and remodeling at the micro-scale and to aid in the development and verification of new graft materials; to provide improved and timely information in real-time for clinical management of osteogenic disease and trauma; and, to monitor bionic interfaces in envisioned smart prosthesis.

Molecular BiosensorsAlan Rosenbloom, Alan Waggoner
By engineering natural proteins such as antibodies, enzymes and signaling proteins, a whole generation of sensor molecules that change colors or light up during crucial intra-cellular event can be used to study processes in living cells. These new technologies will be applied in multiple areas of biology and medicine to understand the basic mechanisms of development and disease, and to microchip-based real-time critical care monitoring.