Carnegie Mellon University



  • Nmezi, Xu, Fu, Armiger, Bey, Powell, Ma, Sullivan, Tu, Chen, Young, Stolz, Dahl, Liu, Padiath

            A concentric model predicts district roles for the A and B type lamins in the spatial organization and stability of the nuclear lamina

            Proceedings of the National Academy of Science USA accepted


  • Whitefield DB, Spagnol ST, Armiger TJ, Lan L, Dahl KN (2018)

            Quantifying site-specific chromatin mechanics and DNA damage response

            Scientific Reports 8(1):18084

  • Gonzalez-Cruz RD, Dahl KN, Darling EM (2018)

            The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype

            Frontiers in Cell and Developmental Biology 6:151

  • Armiger TJ, Lampi MC, Reinhart-King CA, Dahl KN (2018)

            Determining mechanical features of modulated epithelial monolayers using subnuclear     particle tracking

            Journal of Cell Science 131(12)

  • Gao Y, Tan J, …Chen X, Leger B, Xu J, Spagnol ST, Dahl KN, Levine AS, Liu Y, Lan L (2018)

            SIRT6 facilitates directional telomere movement upon oxidative damage.

            Scientific Reports 8(1):5407


  • Jin S, Wijesekara P, Boyer PD, Dahl KN, Islam MF (2017)

            Length-dependent intracellular bundling of single-wall carbon nanotubes influences          retention

            Journal of Materials Chemistry B, 5: 6657-6665

  • Dauson E, Gregory K, Oppenheim I, Dahl KN (2017)

            Human blood cell separation using bulk acoustic waves in a machined PMMA      microchannel

            IEEE International Ultrasonics Symposium

  • Gao Y, Li C, Wei L, Teng Y, Nakajima S, Ma H, Spagnol ST, Leger B, Liu Y, Wan Y, Dahl K,

            Levine A, Chen X, Xu J, Lan L (2017)

  • SSRP1 cooperates with PARP and XRCC1, facilitating single strand break repair through chromatin priming
  • Cancer Research 77(10):2674-2685  
  • Holt BD, Roginskaya V, Van Houten B, Islam MF, Dahl KN (2017)

            Dispersed single wall carbon nanotubes do not impact mitochondria structure or function,

            but technical issues during analysis could yield incorrect results

            Journal of Materials Chemistry B 5: 369-374


  • Armiger TJ, Spagnol ST, Dahl KN (2016)

            Nuclear mechanical resilience but not stiffness is modulated by αII-spectrin

            Journal of Biomechanics 49(16):3983-3989

  • Boyer PD, Ganesh S, Qin Z, Holt BD, Buehler MJ, Islam MF, Dahl KN (2016)
  • Delivering single-walled carbon nanotubes to the nucleus using engineered nuclear protein domains
  • ACS Applied Materials & Interfaces 8(5):3524-34
  • Dahl KN and Luxton GWG (2016)

            A Special Topic on Nuclear Mechanobiology

            Cellular and Molecular Bioengineering  9(2):203-206

  • Spagnol ST, Armiger JA, Dahl KN (2016)

            Mechanobiology of Chromatin and the Nuclear Interior

            Cellular and Molecular Bioengineering  9(2):268-76

  • Boyer BD, Shams H, Baker SL, Mofrad MRK, Islam MF, Dahl KN (2016)
  • Enhanced intracellular delivery of small molecules and drugs via non-covalent ternary dispersions of single wall carbon nanotubes
  • Journal of Materials Chemistry B 4: 1324-1330
  • Spagnol ST, Dahl KN (2016)
  • Spatially resolved quantification of chromatin condensation through differential local rheology in cell nuclei fluorescence lifetime imaging
  • PLoS One 11(1):e0146244


  • Spagnol ST, Lin W, Booth EA, Ladoux B, Lazarus HM, Dahl KN (2015)
  • Early passage dependence of mesenchymal stem cell mechanics influences cellular invasion and migration
  • Annals of Biomedical Engineering 44(7):2123-31
  • Holt BD, Shawky JH, Dahl KN, Davidson LA, Islam MF (2015)

            Distribution of single-wall carbon nanotubes in the Xenopus laevis embryo after    microinjection

  • Journal of Applied Toxicology 36(4):568-78
  • Booth EA, Spagnol ST, Alcoser TA, Dahl KN (2015)
  • Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

            Soft Matter 11(32):6412-8

  • Holt BD, Dahl KN, Islam MF (2015)

            Differential sub-cellular processing of single-wall carbon nanotubes via interfacial             modifications

            Journal of Materials Chemistry B 3:6274-84

  • Dahl KN and Buehler MJ (2015)

            Nucleus Mechanics

            Chapter in Cellular and Molecular Biomechanics, ed. Bradley Layton

  • Holt BD, Law J, Boyer PD, Wilson L, Dahl KN, Islam MF (2015)
  • Sub-cellular partitioning and analysis of Gd3+-loaded ultra-short single-walled carbon nanotubes
  • ACS Applied Materials & Interfaces 7(27):14593-602
  • Holt BD, Shawky JH, Dahl KN, Davidson LA, Islam MF (2015)
  • Developing xenopus embryos recover by compacting and expelling single-wall carbon     nanotubes
  • Journal of Applied Toxicology 36(4):579-85
  • Ganesh S, Qin Z, Spagnol ST, Biegler MT, Coffey K, Kalinowski A, Buehler MJ, Dahl KN         (2015)

            The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A

            Nucleus 6(3):203-11


  • Ribeiro AJ, Khanna P, Sukumar A, Dong C, Dahl KN (2014)
  • Nuclear stiffening inhibits migration of invasive melanoma cells.
  • Cellular and Molecular Bioengineering 7(4):544-551
  • Kalinowski A, Yaron PN, Qin Z, Shenoy S, Buehler MJ, Lösche M, Dahl KN (2014)
  • Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome
  • Biophysical Chemistry 195:43-8
  • Spagnol S, Weltz JA, Xue Y, Dahl KN (2014)
  • Mechanical coupling of the endothelial cytoskeleton and nucleus with VEGF stimulation
  • Cellular and Molecular Bioengineering 7(2): 225-230
  • Booth-Gauthier EA, Spagnol ST, Dahl KN (2014)

            Mechanobiology of the endothelial nucleus

            Chapter in Mechanobiology of the Endothelium, ed. Helim Aranda-Espinoza

  • Spagnol S, Dahl KN (2014)
  • Active cytoskeletal force and chromatin condensation independently modulate intranuclear network fluctuations
  • Integrative Biology 6: 523-531
  • Shams H, Holt BD, Mahboobi SH, Jahed Z, Islam MF, Dahl KN, Mofrad MR (2014)
  • Actin reorganization through dynamic interactions with single-wall carbon nanotubes.
  • ACS Nano 8(1): 188-97


  • Kalinowski A, Qin Z, Coffey K, Kodali R, Buehler MJ, Lösche M, Dahl KN (2013)
  • Calcium Causes a Conformational Change in Lamin A Tail Domain that Promotes Farnesyl-Mediated Membrane Association.
  • Biophysical Journal 104(10):2246-53
  • Booth-Gauthier EA, Du V, Ghibaudo M, Rape AD, Dahl KN, Ladoux B (2013)
  • Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates
  • Integrative Biology 5(3) 569-77


  • Booth-Gauthier EA, Alcoser TA, Yang G, Dahl KN (2012)
  • Force induced changes in subnuclear movement and rheology
  • Biophysical Journal 103 (12): 2423-31
  • Boyer PD, Holt BD, Islam MF, Dahl KN (2012)
  • Decoding membrane- versus receptor-mediated delivery of single-walled carbon nanotubes into macrophages using modifications of nanotube surface coatings and cell activity

            Soft Matter 9: 758-764           

  • Holt BD, McCorry MC, Boyer PD, Dahl KN, Islam MF (2012)

            Not all protein-mediated single-wall carbon nanotube dispersions are equally bioactive

            Nanoscale 4(23): 7425-34

  • Dahl KN, Ribeiro AJS (2012)

            Biophysics of nuclear organization and dynamics

            Chapter 7.9 in Comprehensive Biophysics, ed. Edward H. Egelman

  • Holt BD, Shams H, Horst TA, Basu S, Rape AD, Wang Y-L, Rohde GK, Mofrad M, Islam MF,
  • Dahl KN (2012)
  • Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin
  • Journal of Functional Biomaterials 3(20): 298-417
  • Holt BD, Dahl KN, Islam MF (2012)
  • Cells take up and recover from protein-stabilized single-wall carbon nanotubes with two distinct rates.
  • ACS Nano 6(4):3481-90
  • Ribeiro AJS, Tottey S, Taylor RWE, Bise R, Kanade T, Badylak SF, Dahl KN (2012)
  • Mechanical characterization of adult stem cells from bone marrow and perivascular          niches
  • Journal of Biomechanics 45(7):1280-7
  • Wren NJ, Zhong Z, Schwartz R, Dahl KN (2012)

            Modeling nuclear blebs in a nucleoskeleton of independent filament networks

            Cellular and Molecular Bioengineering 5(1):73-81


  • Choi S, Wang W, Ribeiro AJS, Kalinowski A, Gregg A, Opreska P, Niedernhofer LJ, Rohde       GK, Dahl KN (2011)
  • Multi-space computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders
  • Nucleus  2(6):570-9
  • Yaron PN, Holt BD, Short PA, Losche PM, Islam MF, Dahl KN (2011)
  • Single wall carbon nanotube uptake into cells by endocytosis not membrane penetration
  • Journal of Nanobiotechnology 9:45
  • Qin Z, Kalinowski A, Dahl KN, Buehler MJ (2011)
  • Structure and stability of the lamin A tail domain and HGPS mutant
  • Journal of Structural Biology 175(3): 425-33
  • Dahl KN, Kalinowski A (2011)

            Nucleoskeleton mechanics

            Journal of Cell Science “at a glance” 124(5):675-8

  • Holt BD, Dahl KN, Islam MF (2011)
  • Quantification of uptake and localization of bovine serum albumin-stabilized single-wall carbon nanotubes in different human cell types
  • Small 7(16): 2348-55
  • Zhong Z, Booth-Gauthier EA, Dahl KN (2011)

            aII spectrin stabilizes stress fibers and actin-membrane interactions

            Cellular and Molecular Bioengineering 4(1):106-115


  • Holt BD, Short PA, Rape AD, Wang YL, Islam MF, Dahl KN (2010)

            Carbon nanotubes reorganize actin structures in cells and ex vivo

            ACS Nano 4(8):4872-8

  • Zhong Z, Chang SA, Kalinowski A, Wilson KL, Dahl KN (2010)
  • Stabilization of the spectrin-like domains of nesprin-1alpha by the evolutionarily conserved "adaptive" domain
  • Cellular and Molecular Bioengineering 3(2):139-150
  • Zhong Z, Wilson KL, Dahl KN (2010)
  • Beyond lamins other structural components of the nucleoskeleton.
  • Methods in Cell Biology 98:97-119
  • Dahl KN, Kalinowski A, Pekkan K (2010)
  • Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics.
  • Microcirculation.17(3):179-91           
  • Ribeiro AS, Dahl KN (2010) 

            The nucleus as a central structure in defining the mechanical properties of stem cells.

            IEEE Engineering Medicine and Biology Society; 1:831-4.

Older than 2010

  • Dahl KN, Booth-Gauthier EA, Ladoux B (2009)

            In the middle of it all: Mutual mechanical regulation between the nucleus and the cytoskeleton

            Journal of Biomechanics 43(1):2-8

  • Philip JT and Dahl KN(2008)
  • Nuclear mechanotransduction: response of the lamina to extracellular stress implications in aging

            Journal of Biomechanics 41(15):3164-70

  • Dahl KN, Ribeiro AJS, Lammerding J (2008)

            Nuclear shape, mechanics, and mechanotransduction.

            Circulation Research 102(11):1307-18

  • Rohde GK, Ribeiro AJS, Dahl KN, Murphy RF (2008)
  • Deformation-based nuclear morphometry: Capturing nuclear shape variation in HeLa       cells
  • Cytometry A; 73(4):341-50
  • Lammerding J, Dahl KN, Discher DE, Kamm RD (2007)

            Nuclear mechanics and methods

            Methods in Cell Biology 83: 269-94

  • Pajerowski JD, Dahl KN, Zhong FL, Sammak PJ, Discher DE (2007)
  • Physical plasticity of the nucleus in stem cell differentiation
  • Proceedings of the National Academy of Science USA; 104:15619-24
  • Dahl KN, Scaffidi P, Islam MF, Yodh AG, Wilson KL, Misteli T (2006)
  • Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome
  • Proceedings of the National Academy of Science USA; 103(27):10271-6
  • Subramanian S, Tsai R, Sen S, Dahl KN, Discher DE (2006)
  • Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)-Major differences between mouse and man and implications for signaling
  • Blood Cells, Molecules and Diseases; 36(3):364-72
  • Dahl KN, Engler AJ, Pajerowski JD and Discher DE (2005)
  • Power-law rheology of isolated nuclei with deformation mapping of nuclear sub-  structures
  • Biophysical Journal; 89: 2855-2864
  • Dahl KN, Kahn SM, Wilson KL and Discher DE (2004)
  • The nuclear envelope lamina network has elasticity and incompressibility suggestive of a molecular shock absorber.

            Journal of Cell Science; 117:4779-4786 with Editor’s Highlight and

            Research highlight in October 7, 2004 issue of Nature

  • Dahl KN, Parthasarathy R, Westhoff CM, Layton DM and Discher DE (2004) 

            Protein 4.2 is critical to the CD47-membrane skeleton attachment in the human red cell. 

            Blood 2004; 103:1131-1136 

  • Dahl KN, Westhoff CM, and Discher DE (2003)
  • Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual co-localization with Rh protein complexes.

            Blood; 101:1194-1199

  • Subramanian A, Ma H, Dahl KN, Zhu J and Diamond SL (2002)
  • Adenovirus or HA-2 fusogenic peptide-assisted lipofection increases cytoplasmic levels of plasmid in nondividing endothelium with little enhancement of transgene expression.
  • The Journal of Gene Medicine; 4: 75-83