Carnegie Mellon University

Bin He

Professor and Head, Department of Biomedical Engineering

  • B.S., Electrical Engineering, Zhejiang University, 1982
  • M.S., Electrical Engineering, Tokyo Institute of Technology, 1985
  • Ph.D., Bioelectrical Engineering, Tokyo Institute of Technology, 1988
  • Postdoctoral Fellowship in Biomedical Engineering, Harvard University - M.I.T., 1991
Bin He

Biography

Dr. Bin He received his B.S. in Electrical Engineering from Zhejiang University in 1982, and Ph.D. in Bioelectrical Engineering from Tokyo Institute of Technology, Japan, a Nobel Prize winning campus in 1988, both with the highest honors. He completed a postdoctoral fellowship in Biomedical Engineering at Harvard University - M.I.T. After working as a Research Scientist at M.I.T., he was on the faculty of Electrical Engineering and Bioengineering at the University of Illinois at Chicago, where he was named a University Scholar by the President of the University of Illinois. From 2004-2018, he was a Professor of Biomedical Engineering and Director of Biomedical Functional Imaging and Neuroengineering Laboratory at the University of Minnesota. Later he was appointed as a Distinguished McKnight University Professor and Medtronic-Bakken Chair for Engineering in Medicine. At Minnesota, Dr. He served as Director of the NSF IGERT Neuroengineering Training Program and the NIH Neuroimaging Training Program, Director of Graduate Studies for Neuroengineering Minor, and Director of Undergraduate Studies in Biomedical Engineering. Dr. He was the Founding Director of the Center for Neuroengineering from 2007-2017, and served as the Director of the Institute for Engineering in Medicine from 2012-2017 at the University of Minnesota. In June 2017, Dr. He was named the Head of Department of Biomedical Engineering at Carnegie Mellon University, effective Feb. 1, 2018.

Dr. He's research interests include neuroengineering, functional biomedical imaging, cardiovascular engineering, and medical device. He has published over 240 articles in peer-reviewed core international journals including Neuron, Brain, Journal of Neuroscience, Proceedings of the IEEE, NeuroImage, Human Brain Mapping, Nanomedicine, Heart Rhythm, Epilepsia, Applied Physics Letters, American Journal of Physiology, Journal of Neural Engineering, and various IEEE journals, including IEEE Transactions on Biomedical Engineering, IEEE Transactions on Medical Imaging, IEEE Transactions on Neural Systems and Rehabilitation Engineering, and IEEE Reviews in Biomedical Engineering. He has also delivered over 40 plenary and keynote talks in various international conferences and workshops. Dr. He’s research has been featured by Nature, BBC, CNN, NBC, CBS, ABC, the Wall Street Journal, New York Times, Scientific American, the Economist, New Scientist, US News, NPR, among others. A video describing his work on mind controlled flying robot has been viewed ~900,000 times.

Dr. He’s research has been recognized by a number of awards. He is the recipient of the prestigious IEEE Technical Field Award of Biomedical Engineering and the Academic Career Achievement Award from the IEEE Engineering in Medicine and Biology Society (EMBS). He also received the Distinguished Service Award from IEEE EMBS, the Outstanding Research Award from the International Federation of Clinical Neurophysiology, the Established Investigator Award from the American Heart Association, and the CAREER Award from the National Science Foundation, among others. He is an elected Fellow of the International Academy of Medical and Biological Engineering, IEEE, Biomedical Engineering Society, the American Institute for Medical and Biological Engineering, among others. Dr. He serves or served as an Associate Editor or Editorial Board Member of a number of international journals in the field of biomedical engineering, and is the Editor-in-Chief of IEEE Transactions on Biomedical Engineering. He has served as the General Chair of the International Annual Conference of IEEE Engineering in Medicine and Biology Society (2009), Chair of the IEEE EMBS Forum on Grand Challenges in Neuroengineering (2010), Co-Chair of Scientific Committee of the World Congress on Medical Physics and Biomedical Engineering (2012), Chair of IEEE Life Sciences Grand Challenges Conference (2012), Chair of IEEE EMBS International Conference on Neural Engineering (2013), Chair of NSF Workshop on Mapping and Engineering the Brain (2013), and Chair of IEEE EMBS BRAIN Grand Challenges Conference (2014). He was the 2009-2010 President of IEEE Engineering in Medicine and Biology Society, consisting of 10,000+ members worldwide; and is Chair-elect of the International Academy of Medical and Biological Engineering. He has been a Member of the NIH BRAIN Multi-Council Working Group.

Dr. He has been fortunate to be associated with talented graduate and undergraduate students, and postdoctoral associates, many of whom have taken faculty positions in the US, Canada, Japan, China and Korea, and in major corporations. Many of his Ph.D. students received competitive fellowship awards from various funding agencies or the University, or paper competition awards in international conferences.

Research Interests

Dr. Bin He's major research interests are in the field of neuroengineering and biomedical imaging. His research programs are funded by NIH (NIBIB, NCCIH, NINDS, NIMH, NIDA, NHLBI, NEI, OD) and NSF, among other sponsors. The active research programs in Dr. He's lab involve functional neuroimaging of brain dynamics using high-density EEG, MEG, functional MRI, and electromagneto-acoustic imaging, brain-computer interface, and noninvasive neuromodulation using transcranial focused ultrasound, transcranial magnetic stimulation, and transcranial electrical stimulation.

Multimodal Functional Neuroimaging: Dr. He and his students have developed a unified theory for multimodal neuroimaging integrating the BOLD functional MRI and electrophysiological imaging. Hemodynamic neuroimaging, such as BOLD functional MRI, has high spatial resolution at mm scale but is very slow in time. Electrophysiological neuroimaging has high temporal resolution at ms scale but limited spatial resolution. It has been a major frontier in the functional neuroimaging research to attempt to greatly enhance spatiotemporal resolution by integrating functional MRI with electrophysiological imaging. Dr. He and colleagues have developed a rigorous theory on neurovascular coupling, which provides a principled way of integrating BOLD functional MRI signals with electrophysiological signals for event-related paradigms. The theory has been tested in human visual system and revealed a dramatic improvement in performance in imaging human visual information pathways. Dr. He and his students have further developed new algorithms to integrate fMRI and EEG/MEG signals for oscillatory brain activity. Currently, both theoretical and experimental studies are actively pursued in Dr. He's lab to further develop the high resolution spatiotemporal functional neuroimaging modality, and to study the sensory, motor and cognitive functions of the brain using EEG/fMRI.

Functional Neuroimaging of Epilepsy: Dr. He and colleagues have made significant contributions to high-resolution electrophysiological neuroimaging aiding neurosurgical planning in epilepsy patients. Due to the limited spatial resolution of scalp EEG, it is widely practiced in clinical settings that invasive intracranial recordings are obtained, by placing electrode sensors directly on the surface of or within the brain, to aid neurosurgical planning in patients with intractable epilepsy. Dr. He and his students have developed an innovative epilepsy source imaging methodology, in which causal interactions among sources are identified and imaged from noninvasive EEG recordings. Such imaging provides high spatial resolution in imaging distributed brain sources within the 3-dimensional brain volume and reveals neural interactions and connectivity embedded in the brain networks. Dr. He and colleagues have further developed an ICA based seizure imaging methodology and conducted a rigorous validation study in a group of epilepsy patients to image epileptogenic brain, and demonstrated high consistency between the imaged seizure sources and the epileptogenic zones determined by well established clinical procedures in the same patients. Active research is currently being pursued to further establish electrophysiological neuroimaging as a noninvasive tool aiding surgical planning in epilepsy patients. In addition to EEG, work is also ongoing to image and localize epileptic brain from MEG, as well as functional MRI.

Electrical Properties Imaging: An important research program in Dr. He’s lab is the development and investigation of novel approaches for noninvasive imaging of electrical properties of biological tissues, including bioimpedance imaging. Dr. He and colleagues have proposed and developed a new approach called magnetoacoustic tomography with magnetic induction (MAT-MI) by integrating ultrasound and biomagnetism, in order to obtain high resolution image of electrical impedance of biological tissue. In the MAT-MI approach, the object is placed in a static magnetic field and a pulsed magnetic field. The pulsed magnetic field induces eddy current in the object. Consequently, the object emits ultrasonic waves through the Lorentz force produced by the combination of the eddy current and the static magnetic field. The acoustic waves are then collected by the detectors located around the object for image reconstruction. MAT-MI takes the advantage of excellent contrast of electrical impedance and the high spatial resolution of ultrasound. The recent work demonstrates that the MAT-MI approach can achieve mm spatial resolution in imaging electrical impedance, which represents a significant advancement in comparison with the spatial resolution of conventional electrical impedance imaging approach, and may play a critically important role in early detection of breast cancer. Along the similar line, Dr. He and his colleagues have been developing an MR based electrical properties tomography (EPT) approach using B1 mapping of MR technology to reconstruct subject specific electrical properties distributions. EPT not only has great potential for clinical applications in cancer detection and diagnosis but also promises to provide subject specific SAR mapping, helping managing safety concerns in high or ultrahigh field MRI systems.

Brain-Computer Interface: Dr. He has made pioneering contributions to noninvasive brain-computer interface (BCI) research. This work is aimed at developing novel techniques for effectively decoding the intention of human subjects and controlling external device, which may ultimately benefit patients suffering from neurological disorders such as spinal cord injuries or stroke. Dr. He and his colleagues have developed a time-frequency-spatial approach to extract the extremely weak signals accompanying the “thought” of a human subject using an array of electrode sensors placed over the scalp. This method takes the “signatures” of each individual subject and uses them for optimal decoding of the intention of the human subject. Dr. He has proposed the concept of electrophysiological neuroimaging based BCI – an idea to estimate “virtual” intracranial signals from the noninvasive EEG recordings for substantially improving the performance of noninvasive EEG based BCI. He and his colleagues have been aggressively investigating the mechanisms associated with motor imagery based BCI by using advanced neuroimaging techniques to delineate the brain sources accompanying motor imagery. Recently, Dr. He and his students have developed a 3-dimensional continuous brain-computer interface system to allow human subjects to control the flight of a flying robot from noninvasive brain waves and to control a robotic arm in 3D space. Click the video to see the mind-controlled flying robot.

Neuromodulation: Dr. He and his colleagues are actively pursuing noninvasive neuromodulation modalities including transcranial focused ultrasound (tFUS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial alternate current stimulation (tACS). Current interest ranges from basic studies of mechanisms of tFUS, TMS and tDCS/tACS by means of dynamic brain mapping, to clinical investigations in patients with stroke and schizophrenia. Other than treatment purposes, Dr. He and his students are pursuing perturbation based imaging in which neuromodulation is used to perturb the central nervous systems and responses measured using various neuroimaging methods for better understanding of brain circuits, networks, and functions.

Selected Awards and Recognition

  • IEEE Biomedical Engineering Award, 2017

  • Fellow, Biomedical Engineering Society, 2017

  • Academic Career Achievement Award, IEEE Engineering in Medicine and Biology Society, 2015

  • Distinguished Service Award, IEEE Engineering in Medicine and Biology Society, 2014

  • Outstanding Research Award, International Federation of Clinical Neurophysiology, 2012

  • Fellow, International Academy of Medical and Biological Engineering, 2012

  • Medtronic-Bakken Chair for Engineering in Medicine, 2012

  • President, IEEE Engineering in Medicine and Biology Society (EMBS), 2009 - 2010

  • Distinguished McKnight University Professorship, 2009

  • President, International Society for Functional Source Imaging, 2007-2008

  • Fellow, American Institute of Medical and Biological Engineering, 2005

  • Fellow, IEEE, 2004

  • President, International Society of Bioelectromagnetism, 2002-2005

  • American Heart Association Established Investigator Award, 2001

  • National Science Foundation CAREER Award, 1999

  • University of Illinois University Scholar Award, 1999

Editorial Activities (active) 

Selected Conference Activities

  • International Program Committee Chair, IEEE EMBS Annual International Conference, 2020.
  • Conference Chair, IEEE EMBS BRAIN Grand Challenges Conference, 2014.
  • Conference Co-Chair, IEEE International Symposium on Biomedical Imaging, 2014.
  • Chair, NSF Workshop on Mapping and Engineering the Brain, 2013.
  • Conference Chair, Minnesota Neuromodulation Symposium, 2013-2017.
  • Conference Chair, IEEE EMBS International Conference on Neural Engineering, 2013.
  • Conference Chair, IEEE Life Sciences Grand Challenges Conference, 2012.
  • Co-Chair, Scientific Committee, World Congress on Medical Physics and Biomedical Engineering, 2012.
  • Chair, Steering Committee, IEEE EMBS Forum on Grand Challenges in Neuroengineering, 2010.
  • Conference Chair, the Annual International Conference of IEEE Engineering in Medicine and Biology Society, 2009.

Invited Plenary/Keynote Lectures since 2004

  1. Inverse Imaging: What, How, and the Impact to Health, Plenary Award Lecture, 38th Annual International Conference of IEEE EMBS, Jeju Island, August 2017.
  2. Electrophysiological Neuroimaging and Brain-Computer Interfaces, BRAIN Plenary Symposium Lecture, 38th Annual International Conference of IEEE EMBS, Orlando, August 2016.
  3. Mapping and Interfacing with the Human Brain, Plenary Lecture, IEEE International Joint Conference on Neural Networks, Vancouver, Canada, July 2016.
  4. Mapping Brain Electrophysiological Connectome, Symposium Lecture, Annual Meeting of the Organization for Human Brain Mapping, Geneva, Switzerland, June 2016.
  5. Imaging and Modulating the Human Brain, 2nd BRAIN Initiative Investigators Meeting, Bethesda, Dec 2015.
  6. Bioelectricity and the Brain: From EEG to BCI, Opening Keynote Lecture, International Conference on Basic and Clinical Multimodal Imaging, Utrecht, Netherlands, September 2015.
  7. Dynamic Seizure Imaging and Localization from EEG and High Frequency Activity, International Workshop on Seizure Prediction, Invited Workshop Lecture, Melbourne, Australia, August 2015.
  8. Noninvasive Brain-Computer Interface: Challenges and Opportunities, Symposium Lecture, 7th IEEE EMBS International Conference on Neural Engineering, Montpellier, France, April 2015.
  9. BRAIN Initiative and Dynamic Brain Mapping, Keynote Lecture, International Workshop on Brain Technology Initiative, Shanghai, China, December 2014.
  10. Mapping and Decoding Brain Dynamics in vivo, Plenary Lecture, IEEE EMBS BRAIN Grand Challenges Conference, Washington DC, November 2014.
  11. Dynamic Mapping and Interfacing with the Human Brain, Theme Keynote Lecture, IEEE EMBS Annual International Conference, Chicago, August 2014.
  12. Mind Controlled Medical Devices, Keynote Lecture, MD & M Minneapolis Conference, Minneapolis, October 2013.
  13. High-resolution dynamic neuroimaging of brain activity, NSF Workshop on Mapping and Engineering the Brain, Arlington, August 2013.
  14. Engineering the future of medicine, Plenary Lecture, Design of Medical Devices Conference, Minneapolis, April 2013.
  15. Spatio-Temporal Three-dimensional Cardiac Electric Imaging, Symposium Lecture,The 33rd Annual Scientific Sessions of the Heart Rhythm Society, Boston, May 2012. 
  16. Challenges and Opportunities in Neuroengineering: Understanding and Interfacing with the Brain, Keynote Lecture, Design of Medical Devices Conference, Minneapolis, April 2012.
  17. EEG source and connectivity imaging of epilepsy, Symposium Lecture, American Clinical Neurophysiology Society Annual Meeting, San Antonio, February 2012.
  18. Functional Neuroimaging, Keynote Lecture, Yangtze River International Conference on the Applications of Medical Imaging Physics & The 6th National Annual Meeting of Medical Imaging Physics, Hangzhou, China, October 2011.
  19. Dynamic Integration of EEG with fMRI in Event Related Paradigms and Resting States, Workshop on Multimodal Functional Neuroimaging Integrating EEG, MEG and fMRI: Why and How, 17th Annual Meeting of Organization on Human Brain Mapping, Quebec City, Canada, June 2011 (800+ attended the workshop).
  20. EEG-based Navigational Control of Virtual Helicopter in 3-D Space, DARPA Biologically-driven Navigation (BioNav) Workshop, Arlington, May 2011.
  21. Spatio-Temporal Functional Neuroimaging of Brain Activity, Plenary Lecture, 5thIEEE EMBS International Conference on Neural Engineering, Cancun, April 2011.
  22. Electrical Source and Impedance Imaging: Challenges and Opportunities, Keynote Lecture, Workshop on MR-based Impedance Imaging, Seoul, Korea, December 2010.
  23. Imaging and Interacting with the Brain: Challenges and Opportunities, Plenary Lecture, Annual Conference of Chinese Society of Biomedical Engineering, Beijing, China, December 2010.
  24. Toward High-resolution Spatio-temporal Functional Brain Imaging, Keynote Lecture, IEEE – EMBS Forum on Grand Challenges in Neuroengineering, Bethesda, May 2010.
  25. XIVth Conference on Electrical Biompedance and the 11th Conference on Biomedical Applications of Electrical Impedance Tomography, Plenary Lecture, Gainesville, April 2010.
  26. Emerging Frontiers in Biomedical Engineering and Functional Neuroimaging, Plenary Lecture, Chinese Conference on Biomedical Engineering, Chongqing, China, October 2009.
  27. Neuroengineering: Opportunities and Challenges to Reverse Engineer the Brain, Second International Conference on BioMedical Engineering and Informatics and the Second International Congress on Image and Signal Processing, Keynote Lecture, Tianjin, China, October 2009.
  28. Functional Imaging of Brain and Heart Activity. Plenary Lecture, Joint Meeting of the 7th International Symposium on Noninvasive Functional Source Imaging & 7th International Conference on Bioelectromagnetism, Rome, Italy, May 2009.
  29. Electrophysiological Sensing and Imaging of Cardiac Activity, The Xiangshan Science Conferences 346th Session, Beijing, China, April 2009.
  30. Multimodal Functional Neuroimaging Integrating fMRI and EEG, NIH Blueprint Workshop on Non-invasive Imaging of Brain Structure and Function, Washington DC, September, 2008.
  31. Multimodal Neuroimaging of Brain Activity and Connectivity, Grand Challenges in Neuroscience Workshop, Institute of Medicine of the National Academies, Washington DC, June 2008.
  32. Functional Neuroimaging of Dynamic Brain Activity, Keynote Lecture, 5thInternational Conference on Information Technology and Applications in Biomedicine, Shenzhen, China, May 2008.
  33. Electrophysiological Neuroimaging of Cortical Sources, Symposium Lecture, World Congress on Neuromodulation, Acapulco, Dec 2007.
  34. Electrophysiological Neuroimaging: Past, Present and Future, Keynote Lecture, Joint Meeting of the 6th International Symposium on Noninvasive Functional Source Imaging of Brain and Heart and the International Conference on Functional Biomedical Imaging, Hangzhou, China, October 2007.
  35. Electrophysiological Imaging of Brain and Cardiac Electrical Activity, Keynote Lecture, The 6th International Conference on Bioelectromagnetism, Aizu, October 2007.
  36. Electrocardiographic Imaging: From 2-dimension towards 3-dimension, Plenary Lecture, Joint Meeting of 5th International Conference on Bioelectromagnetism and 5thInternational Symposium on Noninvasive Functional Source Imaging within the Human Brain and Heart, Minneapolis, May 2005.
  37. From High-resolution EEG to Electrophysiological Neuroimaging, Plenary Lecture, 15th International Congress on Brain Electromagnetic Topography, Tokyo, April 2004.

Publications (Please click here for a complete list.)