Service Systems Executive Speaker Series and Working Group
Speaker: Lucila Ohno-Machado,
Founding Chief of New Division of Biomedical Informatics, UC San Diego School of Medicine
Title: Computational challenges in evaluating predictions related to direct-to-consumer genomics
Controversy about the usefulness of certain direct-to-consumer genomics tests have prevented their wide dissemination. Some concerns originate from the fact that it is very difficult to validate predictions, given the relative paucity of reliable associated phenotype data. In this talk, I will describe how efforts to create large clinical data repositories across diverse populations can mitigate this problem. I will discuss techniques for validation of predictions in different data sets. I will also discuss on why it is not simple to de-identify data to make it available for research without compromising patient privacy. Finally, I will describe the work being developed in iDASH, a new National Center for Biomedical Computing focused on integrating data for analysis, anonymization, and sharing.
The University of California, San Diego Health Sciences has appointed Lucila Ohno-Machado, MD, PhD, chief of its new Division of Biomedical Informatics in the Department of Medicine. Ohno-Machado works closely with physicians at the UC San Diego Medical Center, with various academic departments at the university, as well as with scientists at the San Diego Supercomputer Center and the California Institute for Telecommunications and Information Technology (Calit2) at UC San Diego.
“The new division serves as a hub for quantitative biomedical faculty and students at UC San Diego, allowing like-minded scientists to share ideas, resources, and experiences,” said Ohno-Machado.
Dr. Ohno-Machado brings a diversity of experience to this position that will be extremely important for UC San Diego as we develop the infrastructure that will allow us to both learn more about the cause of various diseases, and to analyze our medical practices,” said Kenneth Kaushansky, MD, MACP, Helen M. Ranney Distinguished Professor and Chair of the Department of Medicine.
Before joining UCSD, Ohno-Machado was director of the Harvard-MIT-Tufts-Boston University training program in biomedical informatics as well as director of the Decision Systems Group, a biomedical informatics research unit in the Department of Radiology at Brigham and Women’s Hospital in Boston. She holds a medical degree from the University of São Paulo in Brazil, and received her PhD degree in Medical Information Sciences and Computer Science from Stanford University, where she was a research fellow in medicine from 1991 to 1996.
She then went to Brigham and Women’s Hospital in Boston, serving as an instructor, assistant professor, and associate professor in the Department of Radiology and the Division of Health Sciences and Technology at Harvard-MIT. There, she developed and taught new graduate courses in the computer science department. She is an elected fellow of the American College of Medical Informatics and of the American Institute for Medical and Biological Engineering. Besides her UCSD responsibilities, she is associate editor of the Journal of the American Medical Informatics Association, and will also serve as associate editor of the Journal of Biomedical Informatics starting 2010. She chairs the scientific program committee for the 2009 American Medical Informatics Association Annual Symposium.