The Herpes Virology Group

Carnegie Mellon University, Department of Physics
Principal Investigator: Prof. Alex Evilevitch

http://www.cmu.edu/physics/index.html
 

   NEWS & Events


Links

Virus Particle Explorer

Peter Rand - Osmotic Pressure Data

Key References in Physical Virology

1. Principles of Virus Symmetry

a) Caspar, D. L., and A. Klug. "Physical principles in the construction of regular viruses." Cold Spring Harb Symp Quant Biol 27 (1962): 1-24.

b) Liddington, R. C., Y. Yan, J. Moulai, R. Sahli, T. L. Benjamin, and S. C. Harrison. "Structure of simian virus 40 at 3.8-A resolution." Nature 354 (1991): 278-84.

2. Virus Crystallography and Cryo-EM

a) Wikoff, W. R., L. Liljas, R. L. Duda, H. Tsuruta, R. W. Hendrix, and J. E. Johnson. "Topologically linked protein rings in the bacteriophage HK97 capsid." Science 289 (2000): 2129-33.

b) Wu, L., P. Lo, X. Yu, J. K. Stoops, B. Forghani, and Z. H. Zhou. "Three-dimensional structure of the human herpesvirus 8 capsid." J Virol 74 (2000): 9646-54.

3. Capsid Assembly

a) Conway, J. F., R. L. Duda, N. Cheng, R. W. Hendrix, and A. C. Steven. "Proteolytic and conformational control of virus capsid maturation: the bacteriophage HK97 system." J Mol Biol 253 (1995): 86-99.

b) Prevelige, P. E., Jr., D. Thomas, and J. A. King. "Nucleation and growth phases in the polymerization of coat and scaffolding subunits into icosahedral procapsid shells." Biophys J 64, no. 3 (1993): 824-35.

c) Flint S.J., Enquist L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, Chapter “Packaging the nucleic acid genome”, pp 109-112.

d) Flint S.J., Enquist L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, Chapter “Viruses with envelopes”, pp 114-121.

4. Nucleic Acid Packaging and Ejection

a) D'Souza, V., and M. F. Summers. "Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus." Nature 431, no. 7008 (2004): 586-90.

b) Evilevitch A., Lavelle L, Knobler C.M., Raspaud E, Gelbart  W.M. “Osmotic pressure inhibition of DNA ejection from phage” PNAS , 2003, 100 (16)-9292-5.

c) Smith, D. E., S. J. Tans, S. B. Smith, S. Grimes, D. L. Anderson, and C. Bustamante. "The bacteriophage straight phi29 portal motor can package DNA against a large internal force." Nature 413 (2001): 748-52.

d) Flint S.J., Enquicst L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, Chapter “Mechanism of Entry”, pp 156-170.

e) Flint S.J., Enquicst L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, Chapter “Transport of the viral genome into the nucleus”, pp 172-176.

5. Virus Exit and Release

a) Grundling, A., D. L. Smith, U. Blasi, and R. Young. "Dimerization between the holin and holin inhibitor of phage lambda." J Bacteriol 182, no. 21 (2000): 6075-81.

b) von Schwedler, U. K., M. Stuchell, B. Muller, D. M. Ward, H. Y. Chung, E. Morita, H. E. Wang, T. Davis, G. P. He, D. M. Cimbora, A. Scott, H. G. Krausslich, J. Kaplan, S. G. Morham, and W. I. Sundquist. "The protein network of HIV budding." Cell 114, no. 6 (2003): 701-13.

c) Koester S., Evilevitch A., Jeembaeva M., Weitz D. “Influence of internal capsid pressure on viral infection by phage lambda”, Biophys J. 2009 Sep 16;97(6):1525-9.

6. Virus Recognition and Attachment

a) Modis, Y., S. Ogata, D. Clements, and S. C. Harrison. "Structure of the dengue virus envelope protein after membrane fusion." Nature 427, no. 6972 (2004): 313-9.

b) Steinbacher, S., U. Baxa, S. Miller, A. Weintraub, R. Seckler, and R. Huber. "Crystal structure of phage P22 tailspike protein complexed with Salmonella sp. O-antigen receptors." Proc Natl Acad Sci U S A 93, no. 20 (1996): 10584-8.

7. Virus Entry

a) Bubeck, D., D. J. Filman, N. Cheng, A. C. Steven, J. M. Hogle, and D. M. Belnap. "The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes." J Virol 79, no. 12 (2005): 7745-55.

b) Leiman, P. G., P. R. Chipman, V. A. Kostyuchenko, V. V. Mesyanzhinov, and M. G. Rossmann. "Three-dimensional rearrangement of proteins in the tail of bacteriophage T4 on infection of its host." Cell 118, no. 4 (2004): 419-29.

8. Virus Structures in the Cell

a) Bakkes, P. J., B. W. Faber, H. van Heerikhuizen, and S. M. van der Vies. "The T4-encoded cochaperonin, gp31, has unique properties that explain its requirement for the folding of the T4 major capsid protein." Proc Natl Acad Sci U S A 102, no. 23 (2005): 8144-9.

b) Heath, C. M., M. Windsor, and T. Wileman. "Aggresomes resemble sites specialized for virus assembly." J Cell Biol 153, no. 3 (2001): 449-55.

9. Human Immunodeficiency Virus

a) Baldwin, C. E., R. W. Sanders, Y. Deng, S. Jurriaans, J. M. Lange, M. Lu, and B. Berkhout. "Emergence of a drug-dependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor." J Virol 78, no. 22 (2004): 12428-37

b) Sticht, J., M. Humbert, S. Findlow, J. Bodem, B. Muller, U. Dietrich, J. Werner, and H. G. Krausslich. "A peptide inhibitor of HIV-1 assembly in vitro." Nat Struct Mol Biol 12, no. 8 (2005): 671-7.

10. Virus Nanotechnology

a) Mao, C., D. J. Solis, B. D. Reiss, S. T. Kottmann, R. Y. Sweeney, A. Hayhurst, G. Georgiou, B. Iverson, and A. M. Belcher. "Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires." Science 303, no. 5655 (2004): 213-7.

b) Meunier, S., E. Strable, and M. G. Finn. "Crosslinking of and coupling to viral capsid proteins by tyrosine oxidation." Chem Biol 11, no. 3 (2004): 319-26.

11. RNA Virus Genome Replication and mRNA Production

a) Flint S.J., Enquicst L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, pp 186-212.

12. Transcription Strategies: DNA templates

a) Flint S.J., Enquist L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, pp 254-295.

13. Genome Replication Strategies: DNA Viruses

a) Flint S.J., Enquist L.W., Racaniello V. R., Skalka A. M. “Principles of virology”, pp 298-337.