Facilities-The Pittsburgh NMR Center for Biomedical Research - Carnegie Mellon University

Facilities

MRI Equipment

Bruker BioSpec AV1 4.7 Tesla/40 cm

Bruker AVANCE AV1 4.7-Tesla/40-cm

The 4.7 Tesla system has been the workhorse of the NMR Center. It was originally installed in 1986, and the imaging console has been continuously updated and is currently interfaced with a Bruker AVANCE AVI spectrometer driven by a LINUX workstation and Bruker ParaVision 5.1 imaging software.

System Features

Four receiver channels

Two RF transmitter channels

1 kW RF amplifier

Copely 200A/300V gradient amplifiers

Actively Shielded Gradient Sets

30 cm diameter Magnex gradient set (40 mT/m, 250 μs risetime)

15 cm diameter ACUSTAR gradient set (180 mT/m, 120 μs risetime)

12 cm diameter Bruker BGA-12 gradient set (400 mT/m, 100 μs risetime)

RF Coils

Commercial-built proton imaging probes with 20 cm, 15 cm 72 mm, and 36 mm diameters

Active decoupling for 2-coil operation

Commercial and lab-built surface and array coils 


Bruker BioSpec AV3 7.0 Tesla/21 cm

Bruker AVANCE AV3 7.0-Tesla/21-cmThe 7.0 T/21 cm magnet is shielded with 7 tones of iron plate to reduce the extent of the fringe field. The imaging console is a Bruker AVANCE AVIII spectrometer with four receiver channels driven by a LINUX workstation and Bruker ParaVision 5.1 imaging software.

System Features

Four receiver channels

Two RF transmitter channels

1 kW RF amplifier

Copley 200A/300V gradient amplifiers

Actively Shielded Gradient Sets

12-cm diameter Bruker BGA-12S2 gradient set (480 mT/m, 100 μs risetime) with integrated shims and a 10A shim power supply.

RF Coils

Commercial proton and multinuclear imaging probes with 72 mm and 36 mm diameters

Active decoupling for 2-coil operation

Commercial and lab-built surface and array coils


Bruker AVANCE 500WB 11.7 Tesla/8.9 cm

Bruker AVANCE 500WB 11.7-Tesla/8.9-cm The 11.7 Tesla system has a vertical 89 mm actively shielded superconducting magnet. The magnet is interfaced to a Bruker AVANCE DRX spectrometer driven by a LINUX workstation and Bruker ParaVision 4.0 imaging software.

The system has a micro gradient set with a maximum gradient strength of 1000 mT/m and has a wide variety of RF probes for imaging fixed samples as wells as mice and rats in vivo.

MRS Equipment

Bruker MiniSpec 0.47 Tesla

Bruker MiniSpec 0.47 Tesla The Bruker MiniSpec is available for routine relaxation measurements. The instrument consists of 10 cm and 18 cm RF probes, a temperature controller, a 300W RF amplifier and software for fully automated determination of T1 and T2 relaxation times in tissue samples, cell suspensions, and contrast agents.


High Resolution NMR Spectrometers: 7.0, 11.7, 14.0 Tesla

High Resolution NMR Spectrometers: 7.0-, 11.7-, 14.0-Tesla The NMR Center has access to four high resolution Bruker AVANCE DRX NMR spectrometers. The magnetic field strengths correspond to proton resonance frequencies of 300 MHz, 500 MHz and 600 MHz. These instruments have four RF channels and are routinely used for high resolution protein NMR spectroscopy and NMR spectroscopy of Biological samples and metabolites.