Saadyah Averick - Matyjaszewski Polymer Group - Carnegie Mellon University

Saadyah Averick

Address:
Carnegie Mellon University
4400 Fifth Avenue
Mellon Institute
Pittsburgh, PA 15213
Office: MI-810
Phone: (412) 268-3208

Education

The City University of New York, College of Staten Island, New York.
June 2009
B.S., Double major in Chemistry (Honors in the Major Cum Laude) and Biochemistry (Cum Laude)
Minor- Biology June 2009

Publications

  1. Patrícia V. Mendonça, Dominik Konkolewicz, Saadyah E. Averick, Arménio C. Serra , Anatoliy V. Popov, Tamaz Guliashvili, Krzysztof Matyjaszewski and Jorge F. J. Coelho "Synthesis of cationic poly((3-acrylamidopropyl) trimethylammonium chloride) and its block copolymers by SARA ATRP in ecofriendly solvent mixtures" Polymer Chemisry, 2014,  DOI: 10.1039/C4PY00707G
  2. Patrícia V. Mendonça, Saadyah E. Averick, Dominik Konkolewicz, Arménio C. Serra, Anatoliy V. Popov, Tamaz Guliashvili, Krzysztof Matyjaszewski, and Jorge F. J. Coelho "Straightforward ARGET ATRP for the Synthesis of Primary Amine Polymethacrylate with Improved Chain-End Functionality under Mild Reaction Conditions" Macromolecules, 2014, DOI: 10.1021/ma501007j
  3. Hongkun He, Saadyah Averick, Elliot Roth, David Luebke, Hunaid Nulwala " Clickable Poly(ionic liquid)s for Modification of Glass and Silicon Surfaces" Polymer, 2014, DOI: 10.1016/j.polymer.2014.01.045
  4. Hongkun He, Brian Adzima, Mingjiang Zhong,  Saadyah Averick,  Richard Koepsel, Hironobu Murata, Alan Russell, David Luebke,  Hunaid Nulwala, and Krzysztof Matyjaszewski "Multifunctional Photo-Crosslinked Polymeric Ionic  Hydrogel Films" Polymer Chemistry, 2014DOI: 10.1039/C3PY01708G
  5. Saadyah Averick, Sourav K. Dey, Debasish Grahacharya, Krzysztof Matyjaszewski  and Subha R. Das "Solid Phase Incorporation of an ATRP Initiator for Polymer-DNA Biohybrids" Angewandte Chemie International Edition2014, DOI: 10.1002/anie.201308686
  6. Eric Hsu, Shiguang Liu, Arun Shrivats, April Watt, Shaun McBride, Saadyah Averick, Hong Y. Cho, Krzysztof Matyjaszewski, Jeffery O. Hollinger "Cationic Nanostructured Polymers for siRNA Delivery in Murine Calvarial Pre-Osteoblasts" Journal of Biomedical Nanotechnology2014, 10, 1130-1137 DOI: 10.1166/jbn.2014.1823
  7. Shawon Debnath, Darin Saloum, Sukanta Dolai, Chong Sun, Saadyah Averick, Krishnaswami  Raja, and Jimmie E. Fata "Dendrimer-Curcumin Conjugate: A Water Soluble and Effective Cytotoxic Agent against Breast Cancer Cell  Lines" Anti-Cancer Agents in Medicinal Chemistry2013, 13, 1531-1539 DOI: 10.2174/18715206113139990139
  8. Antonina Simakova, Matthew Mackenzie,  Saadyah  Averick, Sangwoo Park and Krysztof Matyjaszewski "Bioinspired Fe-Based Catalyst for Atom Transfer Radical  Polymerization" Angewandte Chemie International Edition  2013, 135,  12148-12151 DOI: 10.1002/anie.201306337
  9. Saadyah Averick, Eduardo Paredes, Sourav Dey, Krzysztof Matyjaszewski and Subha R. Das "Polymer Escorts for siRNA Delivery"  Journal of the American Chemical Society 2013135,  12508-12511 DOI: 10.1021/ja404520j
  10. Saadyah  Averick, Christopher G. Bazewicz, Bradley F. Woodman, Antonina Simakova, Ryan A. Mehl, and Krzysztof Matyjaszewski "Protein-Polymer Hybrids: Conducting ARGET ATRP from a Genetically Encoded Cleavable ATRP Initiator" European Polymer Journal 2013, 10, 2919-2924  DOI:10.1016/j.eurpolymj.2013.04.015
  11. Hong Y. Cho, Saadyah  Averick, Eduardo Paredes, Katarzyna Wegner, Amram Averick, Stefan Jurga, Subha Das, and Krzysztof Matyjaszewski "Star Polymers with a Cationic Core Prepared by ATRP for Cellular Nucleic Acids Delivery" Biomacromolecules 2013,14, 1262-1267  DOI:10.1021/bm4003199
  12. Felisa Reyes-Ortega, Francisco Parra-Ruiz, Saadyah Averick, Gema Rodríguez, María Rosa Aguilar, Krzysztof Matyjasqewski, Julio San Román "Smart Heparin-Based Bioconjugates Synthesized by a Combination of ATRP and Click Chemistry" Polymer Chemistry, 2013, 4, 2800-2814 DOI: 10.1039/c3py00055a
  13. Saadyah  Averick, Eduardo Pardes, Ainara Irastorza, Abiraman Srinivasan, Daniel J. Siegwart, Andrew J. Magenau, Hong Y. Cho, Arun R. Shrivats, Eric Hsu, Jinku Kim, Shiguang Liu, Jeffrey O. Hollinger, Subha R. Das, and Krzysztof Matyjaszewski "Preparation of Cationic Nanogels for Nucleic Acid Delivery" "Biomacromolecules2012, 13, 3445-3449 DOI: 10.1021/bm301166s
  14. Antonina Simakova, Saadyah Averick, Dominik Konkolewicz, Krzysztof Matyjaszewski "Aqueous ARGET ATRP" Macromolecules201245,  6371-6379 DOI: 10.1021/ma301303b
  15. Dominik Konkolewicz, Andrew J. D. Magenau, Saadyah Averick, Antonina Simakova, Hongkun He, and Krzysztof Matyjaszewski "ICAR ATRP with ppm Cu Catalyst in Water" Macromolecules, 2012, 45, 4461-4468 DOI:10.1021/ma300887r
  16. Alper Nese, Yuanchao Li, Saadyah Averick, Yungwan Kwak, Dominik Konkolewicz, Sergei S. Sheiko, and Krzysztof Matyjaszewski "Synthesis of Amphiphilic Poly(N-vinylpyrrolidone)-b-poly(vinyl acetate) Molecular Bottlebrushes" ACS Macro Letters, 20121, 227-231 DOI: 10.1021/mz200134n
  17. Saadyah E. Averick, Eduardo Paredes, Debasish Grahacharya, Bradley F. Woodman, Shigeki J. Miyake-Stoner, Ryan A. Mehl, Krzysztof Matyjaszewski, and Subha R. Das "A Protein-Polymer Hybrid Mediated By DNA" Langmuir, 2012, 28, 1954-1958 DOI: 10.1021/la204077v
  18. Saadyah Averick, Antonina Simakova, Sangwoo Park, Dominik Konkolewicz, Andrew J. D. Magenau, Ryan A. Mehl, and Krzysztof Matyjaszewski "ATRP under Biologically Relevant Conditions: Grafting from a Protein" ACS Macro Letters,  20121, 6-10 DOI: 10.1021/mz200020c
  19. Sukanta Dolai, Wei Shi, Christopher Corbo, Chong Sun, Saadyah Averick, Dinali Obeysekera, Mina Farid, Alejandra Alonso, Probal Banerjee, and Krishnaswami Raja ""Clicked" Sugar-Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations" ACS Chemical Neuroscience. 2011, 2, 694-699 DOI: 10.1021/cn200088r
  20. Alper Nese, Natalia Lebadeva, Gizelle Sherwood, Saadyah Averick, Yuanchao Li, Haifeng Gao, Linda Peteanu, Sergei Sheiko, and Krzysztof Matyjaszewski "Synthesis of pH Sensitive Fluorescent Molecular Brushes" Macromolecules, 2011, 44, 5905-5910 DOI: 10.1021/ma201045c
  21. Saadyah Averick, Eduardo Paredes, Wenwen Li, Krzysztof Matyjaszewski, and Subha R. Das "Direct DNA Conjugation to Star Polymers for Controlled Reversible Assemblies" Bioconjugate Chemistry, 2011, 22, 2030-2037 DOI: 10.1021/bc200240q
  22. Saadyah Averick , Andrew J. D. Magenau, Antonina Simakova, Bradley F. Woodman , Andrew Seong,  Ryan A. Mehl , and Krzysztof Matyjaszewski "Covalent Incorporated Protein-Nanogels using AGET ATRP in an Inverse Miniemulsion" Polymer Chemistry,  2011, 2, 1476-1478 DOI: 10.1039/C1PY00050K  
  23. Jennifer C. Peeler, Bradley F. Woodman, Saadyah Averick, Shigeki J. Miyake-Stoner, Audrey L. Stokes, Kenneth R. Hess, Krzysztof Matyjaszewski, and Ryan A. Mehl "Genetically Encoded Initiator for Polymer Growth from Proteins" Journal of the American Chemical Society, 2010, 132, 13575-13577 DOI: 10.1021/ja104493d
  24. Wei Shi, Sukanta Dolai, Saadyah Averick, Suraj S. Fernando, Jose A. Saltos, William L'Amoreaux, Probal Banerjee and Krishnaswami Raja "A General Methodology Toward Drug/Dye Incorporated Living Copolymer-Protein Hybrids: (NIRF Dye-Glucose) Copolymer-Avidin/BSA Conjugates as Prototypes" Bioconjugate Chemistry, 2009, 20, 1595-1601 DOI: 10.1021/bc900142y
  25. Wei Shi, Sukanta Dolai, Samar Rizk, Afshan Hussain, Hussnain Tariq, Saadyah Averick, William L'Amoreaux, Abdeslem El Idrissi, Probal Banerjee, and Krishnaswami Raja "Synthesis of Monofunctional Curcumin Derivatives, Clicked Curcumin Dimer, and a PAMAM Dendrimer Curcumin Conjugate for Therapeutic Applications" Organic Letters, 2007, 9, 5461-5464 DOI: 10.1021/ol702370m
  26. Saadyah Averick, Orsolya Karácsony, Jacob Mohin, Dr. Xin Yong, Nicholas M. Moellers, Bradley F. Woodman, Prof. Weipu Zhu, Prof. Ryan A. Mehl, Prof. Anna C. Balazs, Prof. Tomasz Kowalewski and Prof. Krzysztof Matyjaszewski "Cooperative, Reversible Self-Assembly of Covalently Pre-Linked Proteins into Giant Fibrous Structures" Angewandte Chemie International Edition2014, DOI: 10.1002/anie.201402827

Patents

  1. WO 2009-US44371(Filed May 18, 2009); Living copolymer protein/peptide hybrids for biomedical applications, Raja, Krishnaswami; Shi, Wei; Dolai, Sukanta; Averick, Saadyah; L'Amoreaux, William; Banerjee, Probal.
  2. Krishnaswami Raja, Wei Shi, Sukanta Dolai, Saadyah Averick, William  L'Amoreaux, Probal. Banerjee, Living copolymer protein/peptide hybrids for biomedical applications: PCT Appl. WO 2009140683 A1 20091119.
  3. Krishnaswami Raja, Alejandra Alonso, Probal Banerjee, Sukanta Dolai, Christopher Corbo, Saadyah Averick, Amit Mogha, Shawon Debnath, (2011) Preparation of curcumin triazolyl galactosides via click chemistry as antioxidants: PCT In Appl. WO 2011106691 A2 20110901.

Presentations

  • The 236th ACS National Meeting, Philadelphia, PA, USA. August 17-21, 2008.

Awards

  • 2006 Dean’s List (for 3 years)
  • 2007 CSI Undergraduate Summer Research Grant
  • 2008 S.T.E.A.M. Summer Research Grant
  • 2008 POLYED  Undergraduate Organic Chemistry Award

Experience

9/2006-7/2009     College of Staten Island, Department of Chemistry,
Advisor: Dr. Krishnaswami Raja

  • Perform synthesis and purification of organic compounds, polymers, and bioconjugates.
  • Characterize organic compounds, polymers, and bioconjugates.
  • Conducted biological assays of synthesized compounds.
  • Oversee lab maintenance and supplies.


7/2009-Present     Carnegie Mellon University, Department of Chemistry,    
Advisor: Krzysztof Matyjaszewski

  • Synthesis of hydrogels for wound repair.
  • Preparation of protein-polymer hybrids by Grafting From protein initiator.
  • Utilizing DNA as a method to prepare bioassemblies.