Saadyah Averick

Education

The City University of New York, College of Staten Island, New York.
June 2009
B.S., Double major in Chemistry (Honors in the Major Cum Laude) and Biochemistry (Cum Laude)
Minor- Biology June 2009

Publications

1. Hong Y. Cho, Saadyah  Averick, Eduardo Paredes, Katarzyna Wegner, Amram Averick, Stefan Jurga, Subha Das, and Krzysztof Matyjaszewski "Star Polymers with a Cationic Core Prepared by ATRP for Cellular Nucleic Acids Delivery" Biomacromolecules ASAP DOI:10.1021/bm4003199

2. Saadyah  Averick, Bradley F. Woodman, Ryan A. Mehl, Krzysztof Matyjaszewski "Protein as Monomers: Step-Growth Polymerization of a Genetically engineered Diazide Green Fluorescent Protein" to be submitted to Proceedings of the National Academy of Sciences

3. Saadyah  Averick, Christopher G. Bazewicz, Bradley F. Woodman, Antonina Simakova, Ryan A. Mehl, and Krzysztof Matyjaszewski"Protein-Polymer Hybrids: Conducting ARGET ATRP from a Genetically Encoded Cleavable ATRP Initiator" Accepted European Polymer Journal

4. Shawon Debnath, Darin Saloum, Sukanta Dolai, Chong Sun, Saadyah Averick, Krishnaswami  Raja, and Jimmie E. Fata "Dendrimer-Curcumin Conjugate: A Water Soluble and Effective Cytotoxic Agent against Breast Cancer Cell  Lines" Accepted  to Anti-Cancer Agents in Medicinal Chemistry

5. Felisa Reyes-Ortega, Francisco Parra-Ruiz, Saadyah Averick, Gema Rodríguez, María Rosa Aguilar, Krzysztof Matyjasqewski, Julio San Román "Smart heparin-based bioconjugates synthesized by a combination of ATRP and click chemistry" Polymer Chemistry,2013, 4, 2800-2814 DOI: 10.1039/c3py00055a

6. Saadyah  Averick, Eduardo Pardes, Ainara Irastorza, Abiraman Srinivasan, Daniel J. Siegwart, Andrew J. Magenau, Hong Y. Cho, Arun R. Shrivats, Eric Hsu, Jinku Kim, Shiguang Liu, Jeffrey O. Hollinger, Subha R. Das, and Krzysztof Matyjaszewski "Preparation of Cationic Nanogels for Nucleic Acid Delivery" "Biomacromolecules, 2012, 13, 3445-3449 DOI: 10.1021/bm301166s

7. Antonina Simakova, Saadyah Averick, Dominik Konkolewicz, Krzysztof Matyjaszewski "Aqueous ARGET ATRP" Macromolecules,2012, 45, 6371-6379 DOI: 10.1021/ma301303b

8. Dominik Konkolewicz, Andrew J. D. Magenau, Saadyah Averick, Antonina Simakova, Hongkun He, and Krzysztof Matyjaszewski "ICAR ATRP with ppm Cu Catalyst in Water" Macromolecules, 2012, 45, 4461-4468 DOI:10.1021/ma300887r

9. Alper Nese, Yuanchao Li, Saadyah Averick, Yungwan Kwak, Dominik Konkolewicz, Sergei S. Sheiko, and Krzysztof Matyjaszewski "Synthesis of Amphiphilic Poly(N-vinylpyrrolidone)-b-poly(vinyl acetate) Molecular Bottlebrushes" ACS Macro Letters, 2012, 1, 227-231 DOI:10.1021/mz200134n

10. Saadyah Averick, Eduardo Paredes, Wenwen Li, Krzysztof Matyjaszewski, and Subha Das "Direct DNA Conjugation of Star Polymers for Controlled Reversible Assemblies" Langmuir, 2012, 28, 1954-1958 DOI: 10.1021/la204077v

11. Saadyah Averick, Antonina Simakova, Sangwoo Park, Dominik Konkolewicz, Andrew J. D. Magenau, Ryan A. Mehl, and Krzysztof Matyjaszewski "ATRP under Biologically Relevant Conditions: Grafting from a Protein" ACS Macro Letters,  2012, 1, 6-10 DOI: 10.1021/mz200020c

12. Sukanta Dolai, Wei Shi, Christopher Corbo, Chong Sun, Saadyah Averick, Dinali Obeysekera, Mina Farid, Alejandra Alonso, Probal Banerjee, and Krishnaswami Raja ""Clicked" Sugar-Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations" ACS Chemical Neuroscience. 2011, 2, 694-699 DOI: 10.1021/cn200088r

13. Alper Nese, Natalia Lebadeva, Gizelle Sherwood, Saadyah Averick, Yuanchao Li, Haifeng Gao, Linda Peteanu, Sergei Sheiko, and Krzysztof Matyjaszewski "Synthesis of pH Sensitive Fluorescent Molecular Brushes" Macromolecules, 2011, 44, 5905-5910 DOI: 10.1021/ma201045c

14. Saadyah Averick, Eduardo Paredes, Wenwen Li, Krzysztof Matyjaszewski, and Subha R. Das "Direct DNA Conjugation to Star Polymers for Controlled Reversible Assemblies" Bioconjugate Chemistry, 2011, 22, 2030-2037 DOI: 10.1021/bc200240q

15. Saadyah E. Averick , Andrew J. D. Magenau, Antonina Simakova, Bradley F. Woodman , Andrew Seong,  Ryan A. Mehl , and Krzysztof Matyjaszewski "Covalent Incorporated Protein-Nanogels using AGET ATRP in an Inverse Miniemulsion" Polymer Chemistry, 2011, 2, 1476-1478 DOI: 10.1039/C1PY00050K  

16. Jennifer C. Peeler, Bradley F. Woodman, Saadyah Averick, Shigeki J. Miyake-Stoner, Audrey L. Stokes, Kenneth R. Hess, Krzysztof Matyjaszewski, and Ryan A. Mehl "Genetically Encoded Initiator for Polymer Growth from Proteins" Journal of the American Chemical Society, 2010, 132, 13575-13577 DOI: 10.1021/ja104493d

17. Wei Shi, Sukanta Dolai, Saadyah Averick, Suraj S. Fernando, Jose A. Saltos, William L'Amoreaux, Probal Banerjee and Krishnaswami Raja "A General Methodology Toward Drug/Dye Incorporated Living Copolymer-Protein Hybrids: (NIRF Dye-Glucose) Copolymer-Avidin/BSA Conjugates as Prototypes" Bioconjugate Chemistry, 2009, 20, 1595-1601 DOI: 10.1021/bc900142y

18. Wei Shi, Sukanta Dolai, Samar Rizk, Afshan Hussain, Hussnain Tariq, Saadyah Averick, William L'Amoreaux, Abdeslem El Idrissi, Probal Banerjee, and Krishnaswami Raja "Synthesis of Monofunctional Curcumin Derivatives, Clicked Curcumin Dimer, and a PAMAM Dendrimer Curcumin Conjugate for Therapeutic Applications" Organic Letters, 2007, 9, 5461-5464 DOI: 10.1021/ol702370m

Presentations

• The 236th ACS National Meeting, Philadelphia, PA, USA. August 17-21, 2008.

Patents

1. WO 2009-US44371(Filed May 18, 2009); Living copolymer protein/peptide hybrids for biomedical applications, Raja, Krishnaswami; Shi, Wei; Dolai, Sukanta; Averick, Saadyah; L'Amoreaux, William; Banerjee, Probal.
2. Krishnaswami Raja, Wei Shi, Sukanta Dolai, Saadyah Averick, William  L'Amoreaux, Probal. Banerjee, Living copolymer protein/peptide hybrids for biomedical applications: PCT Appl. WO 2009140683 A1 20091119.
3. Krishnaswami Raja, Alejandra Alonso, Probal Banerjee, Sukanta Dolai, Christopher Corbo, Saadyah Averick, Amit Mogha, Shawon Debnath, (2011) Preparation of curcumin triazolyl galactosides via click chemistry as antioxidants: PCT In Appl. WO 2011106691 A2 20110901.

Awards

• 2006 Dean’s List (for 3 years)
• 2007 CSI Undergraduate Summer Research Grant
• 2008 S.T.E.A.M. Summer Research Grant
• 2008 POLYED  Undergraduate Organic Chemistry Award

Experience

9/2006-7/2009     College of Staten Island, Department of Chemistry,
Advisor: Dr. Krishnaswami Raja

• Perform synthesis and purification of organic compounds, polymers, and bioconjugates.
• Characterize organic compounds, polymers, and bioconjugates.
• Conducted biological assays of synthesized compounds.
• Oversee lab maintenance and supplies.

7/2009-Present     Carnegie Mellon University, Department of Chemistry,    
Advisor: Krzysztof Matyjaszewski

• Synthesis of hydrogels for wound repair.
• Preparation of protein-polymer hybrids by Grafting From protein initiator.
• Utilizing DNA as a method to prepare bioassemblies.