Alex John London
Professor of Philosophy
Director, The Center for Ethics and Policy
BioAlex John London is Professor of Philosophy and Director of The Center for Ethics and Policy at Carnegie Mellon University. Professor London is an elected Fellow of the Hastings Center and recipient of the Distinguished Service Award from the American Society of Bioethics and Humanities (ASBH) and a New Directions Fellowship from the Andrew W. Mellon Foundation.
Professor London's research focuses on foundational ethical issues in human-subjects research, issues of social justice in the trans-national context, and on methodological issues in theoretical and applied ethics. His papers have appeared in Mind, Science, The Lancet, PLoS Medicine, Statistics In Medicine, The Hastings Center Report, and numerous other journals and collections. He is co-editor of Ethical Issues in Modern Medicine, one of the most widely used textbooks in medical ethics.
In 2012 he joined the Working Group on the Revision of the CIOMS 2002 International Ethical Guidelines for Biomedical Research Involving Human Subjects and in 2011 he was appointed to the Steering Committee on Forensic Science Programs for the International Commission on Missing Persons (ICMP). Since 2007 he has served as a member of the Ethics Working Group of the HIV Prevention Trials Network. He has testified before the Presidential Commission for the Study of Bioethical Issues and has been commissioned to write papers for the Centers for Disease Control and Prevention (CDC) and the Institute of Medicine (IOM). He has served as an ethics expert in consultations with numerous national and international organizations including U.S. National Institutes of Health, the World Health Organization (here, and here), the World Medical Association (here, and here) and the World Bank.
Professor London is an affiliated faculty member of the Center for Bioethics and Health Law at the University of Pittsburgh and was previously a Visiting Scholar at the Harvard University Program in Ethics and Health. Before joining Carnegie Mellon in 2000, he was a post-doctoral fellow at the University of Minnesota's Center for Bioethics and he received his PhD in Philosophy from the University of Virginia.
MultimediaTestimony before the 13th Meeting of the Presidential Commission for the Study of Bioethical Issues
Science Podcast: DNA Identification After Conflict or Disaster
NPR All Things Considered: "After Disasters, DNA Science is Helpful, But Often Too Pricey"
The PDFs of these papers are intended for personal academic use only and should not be distributed in any way.
|Athanasiou E, London AJ, Zollman KJS. (2015) "Dignity and the Value of Rejecting Profitable but Insulting Offers." Mind. (forthcoming).|
|Jonathan Kimmelman and Alex John London, “The Structure of Clinical Translation: Efficiency, Information, and Ethics,” Hastings Center Report 45 (2015): 1–7. DOI: 10.1002/hast.433.
|Ethical Issues In Modern Medicine, 8th edition. Bonnie Steinbock, Alex John London, John D. Arras. McGraw Hill, 2012.|
|DNA Identification After Conflict or Disaster. Alex John London, Lisa S. Parker, Jay D. Aronson. Science 13 September 2013: Vol. 341 no. 6151 pp. 1178-1179 DOI: 10.1126/science.1238085
|Schenker Y, Arnold R, London AJ. 2014. "The Ethics of Advertising for Healthcare Services." American Journal of Bioethics 14 (3): 34-43. (Link)|
|Schenker Y, London AJ. Risks of Imbalanced Information on US Hospital Websites. JAMA Intern Med. Published online January 12, 2015. doi:10.1001/jamainternmed.2014.7400|
|"Placebo use in vaccine trials: Recommendations of a WHO expert panel” (2014) Annette Rid, Abha Saxena, Abdhullah H. Baqui, Anant Bhan, Julie Bines, Marie-Charlotte Bouesseau, Arthur Caplan, James Colgrove, Ames Dhai, Rita Gomez-Diaz, Shane K. Green, Gagandeep Kang, Rosanna Lagos, Patricia Loh, Alex John London, Kim Mulholland, Pieter Neels, Punee Pitisuttithum, Samba Cor Sarr, Michael Selgelid, Mark Sheehan, et al. Vaccine 32(37): 4708-4712 (PDF)|
Ethics of Research Regulation and Oversight
|London AJ. (2013) Justification, Coherence and Consistency of Provisions in the Revised Declaration of Helsinki. World Medical Journal 59(5): 188-192.
|London AJ. 2012. A Non-Paternalistic Model of Research Ethics and Oversight:Assessing the Benefits of Prospective Review. Journal of Law, Medicine, and Ethics 40(4):930-944. DOI: 10.1111/j.1748-720X.2012.00722.x
|Rethinking Research Ethics: The Case of Postmarketing Trials. Alex John London, Jonathan Kimmelman, Benjamin Carlisle. Science 4 May 2012: Vol. 336 no. 6081 pp. 544-545 DOI: 10.1126/science.1216086
|Beyond Access vs. Protection in Trials of Innovative Therapies. Alex John London, Jonathan Kimmelman, and Marina Elena Emborg
Science 14 May 2010: 829-830.
|London AJ, Borasky DA Jr, Bhan A, for the Ethics Working Group of the HIV Prevention Trials Network (2012) Improving Ethical Review of Research Involving Incentives for Health Promotion. PLoS Med 9(3):
e1001193. doi:10.1371/journal.pmed.1001193 [PDF]
|Kimmelman J, London AJ (2011) Predicting Harms and Benefits in Translational Trials: Ethics, Evidence, and Uncertainty. PLoS Med 8(3): e1001010. doi:10.1371/journal.pmed.1001010 [PDF]|
Risk in Clinical Research, Equipoise, and the Integrative Approach
|Reasonable Risks In Clinical Research: A Critique and a Proposal for the Integrative Approach. Alex John London (2006) Statistics In Medicine 25:2869-2885. DOI: 10.1002/sim.2634.
[PDF of published article from Wiley InterScience]
[PDF of unpaginated pre-print]
|Two Dogmas of Research Ethics and the Integrative Approach to Human-Subjects Research. Alex John London (2007) Journal of Medicine and Philosophy 32 (2): 99-116. DOI:10.1080/03605310701255727
|Clinical Equipoise: Foundational Requirement or Fundamental Error? Alex John London (2007) in Bonnie Steinbock (ed.) The Oxford Handbook of Bioethics. New York: Oxford University Press: 571-596.
|Equipoise and the Criteria for Reasonable Action. Evans EL & London AJ. (2006) Journal of Law Medicine and Ethics 34 (2): 441-450.
|The Moral Foundations of Equipoise and Its Role in International Research. Alex John London (2006) The American Journal of Bioethics 6(4):48-50.
|Threats to the Common Good: Biochemical Weapons and Human Subjects Research. Alex John London (2003). The Hastings Center Report 33(5): 17-25.
Ethics of International Research
|London AJ and Zollman K.Z. (2010). Research at the Auction Block: Problems for the Fair Benefits Approach to International Research. The Hastings Center Report 40(4):34-45.
|London AJ and Kimmelman J. (2008). Justice in Translation: From Bench to Bedside in the Developing World. The Lancet 372 (9632): 82-85.
|London AJ. (2008). Responsiveness to Host Community Health Needs. in Ezekiel J. Emanuel, Christine Grady, Robert Crouch, Reidar Lie, Franklin Miller, and David Wendler eds., The Oxford Textbook of Clinical Research Ethics. (New York: Oxford University Press) pp. 737-744.
|London AJ. (2005). Justice and the Human Development Approach to International Research. The Hastings Center Report 35(1): 24-37.
|London AJ. (2001). "Equipoise and International Human-Subjects Research." Bioethics 15(4) 4: 312-332.
|London AJ. (2000). "The Ambiguity and the Exigency: Clarifying 'Standard of Care' Arguments in International Research."Journal of Medicine and Philosophy 25(4): 379-397.
Ethical Issues in Innovation: Surgery and Movement Disorders
|Kimmelman J, London AJ, Ravina B, Ramsay T, Bernstein M, Fine A, Stahnisch F, Emborg ME. (2009). "Launching Invasive, First-in-Human Trials Against Parkinson’s Disease: Ethical Considerations". Movement Disorders. [Abstract]|
|London AJ. (2006). "Sham Surgery and Reasonable Risk" in David Benatar ed. Cutting to the Core: Exploring the Ethics of Contested Surgeries. New York: Rowman & Littlefield Publishers, Inc. 211-228.
|London AJ. (2006).“Cutting Surgical Practice at the Joints: Individuating and
Assessing Surgical Procedures.” in Angelique M. Rietsma and Jonathan D. Moreno eds., Ethical Guidelines for Innovative Surgery. (Hagerstown, MD: University Publishing Group) 19-52.
|London AJ, Kadane JB. (2002). "Placebos That Harm: Sham Surgery Controls in Clinical Trials." Statistical Methods in Medical Research 11(5): 413-428.
(This paper was a finalist for the 2002 Mark S. Ehrenreich Prize in health care ethics.)
|London AJ, Kadane JB (2003). “Sham Surgery and Genuine Standards of Care: Can the Two be Reconciled?” The American Journal of Bioethics 3 (4): 61-64.
[PDF] from Project Muse
|London AJ. (2001). "The Maltese Conjoined Twins: Two Views of Their Separation." The Hastings Center Report 31; 1: 48-52.
Methodology and Moral Psychology in Theoretical and Applied Ethics
|London AJ. (2001). "Moral Knowledge and the Acquisition of Virtue in Aristotle's Nicomachean and Eudemian Ethics." The Review of Metaphysics 54(3): 500-531.
|London AJ. (2001). "The Independence of Practical Ethics." Theoretical Medicine and Bioethics 22(2): 87-105.
|London AJ. (2000). "Amenable to Reason: Aristotle's Rhetoric and the Moral Psychology of Practical Ethics." Kennedy Institute of Ethics Journal 10(4): 287-305.
|London AJ. (1998). "Virtue and Consequences: Hobbes on the Value of the Moral Virtues." Social Theory and Practice 24; 1:1-23.
Selected Past Lectures
Apr. 25, 2012. “Ethical Challenges in Research Involving Financial Incentives In Resource Scarce Environments,” Invited Plenary, U.S. Government Evidence Summit: Enhancing Provision and Use of Maternal Health Services through Financial Incentives, Washington, DC.
Apr. 12, 2012. “Transparency in Solar Radiation Management Research and Development,” Workshop on Managing Knowledge About How to Perform Solar Radiation Management, American Association for the Advancement of Science, Washington DC.
Dec. 15, 2011. “Responsiveness, Access, and Partnerships for Inquiry,” Conference on Post Trial Access to Trial Drugs: Legal, Ethical, and Practical Issues, Broucher Foundation, Geneva Switzerland.
Nov. 11, 2011. “Rethinking the Role of IRBs” Research Ethics: Reexamining Key Concerns, Wake Forest University.
Oct. 25, 2011. “Ethical Issues and Institutions of DNA Identification,” International Commission on Missing Persons (ICMP), Steering Committee on Forensic Sciences Programs, Sarajevo, Bosnia Herzegovina.
Oct. 6, 2011. “Incentives and the Ethics of Influencing Patient Behavior in HIV Prevention” Grand Rounds, Columbia University HIV Center for Clinical and Behavioral Studies.
Jul. 24, 2011. “The Integrative Approach to Clinical Trials of Charged Particle Radiotherapy” Institute for Science and Ethics and the Particle Therapy Cancer Research Institute, Oxford University.
Jul. 15, 2011. "Fair Benefits and Placebo Controls” The World Medical Association Expert Conference on The Ethics of Placebo Controls in Clinical Trials, Sao Paulo, Brazil.
Jun. 6, 2011. “Ethical Issues in Behavioral Economics and Combination Prevention” Invited Plenary, HIV Prevention Trials Network Annual Meeting, Washington DC.
Jan. 11, 2011. “Human Rights and Human-Subjects Research: Beyond the IRB” AAAS Science and Human Rights Coalition Meeting, Washington DC.
Nov. 9, 2010. "Research and Global Health: Some Considerations of Justice” Yale University seminar on Global Health Ethics, Politics and Economics.
Oct. 4, 2010. "Assessing the Scope, Limits, and Value of Clinical Equipoise.” The Arkansas Medical Society Distinguished Lecture.
July 23, 2010. "Ethics and Clinical Trial Design.” Combination Biomedical HIV Prevention Modalities Workshop: Research Design and Ethical Considerations, sponsored by the National Institutes of Allergy and Infectious Disease and the U.S. Department of Health and Human Services, Rockville.
Feb. 17, 2010. "Research in a Public Health Crisis: The Integrative Approach to Managing the Moral Tensions.” Public Health Preparedness Summit, Atlanta GA.
Nov. 14, 2009. Is Research Morally Special: Justice, Respect, and Reasonable Regulation.” Invited plenary presentation at the annual meeting of Public Responsibility In Medicine and Research (PRIMR). (I gave 3 additional talks at this meeting as well).
Oct. 18, 2009. "Some Problems for the Principle of Permissible Exploitation.” American Society for Bioethics and Humanities.
June 10, 2009. “Research vs. Surveillance and Other Public Health Practices: Definitions and Respective Ethical and Procedural Implications” World Health Organization, Geneva.
May 27, 2009. “Gene Therapy Research in the Developing World: Some Considerations of Justice” American Society of Gene Therapy (invited paper).
April 11, 2009. “Market Forces and Fair Benefits: Some Problems for Procedural Approaches to Justice in International Research” American Philosophical Association, Pacific Meeting.
November 23, 2008. “Clinical Research in A Public Health Crisis: The Integrative Approach Managing Uncertainty and Mitigating Conflict” Seton Hall Law School.
September 25, 2008. “Responsiveness to Host Community Health Needs: Clarifying the Requirement” University of North Carolina at Chapel Hill Medical School.
March 24th 2008. “Why and How are Considerations of Justice Relevant to the Conduct of International Medical Research?” Michigan State University.
November 11th 2007. “Uncertainty, Utility, and Ethics in First-in-Human Trials” Workshop on First-In Human Trials in Parkinson’s Disease, McGill University.
October 10, 2007. “From Equipoise to the Integrative Approach” A Conference in Honor of Benjamin Freedman, McGill University.
July 11th 2007. "A Primer on Justice and the Human Development Approach to International Research" University of Maryland Medical Center, the Middle East training program of the Fogarty International Center of the National institutes of Health.
Feb. 20th 2007. “Ensuring that International Research is Responsive to Host Community Health Needs: Clarifying the Requirement” Duke University Medical Center.
Feb 19th 2007. “Reasonable Risk in Clinical Research” Duke University Philosophy Department.
November 7-8th 2006. “Reasonable Risk in Clinical Research” and “The Responsiveness to Host Community Health Needs Requirement” for the training program in Buenos Aires, Argentina of the Fogarty International Center of the National institutes of Health.
August 6th 2006. “Responsiveness to Host Community Health Needs” 8th World Congress of Bioethics, International Association of Bioethics, Beijing, China.
October 27th 2006. “Community Benefits In International Research” the American Society for Bioethics and Humanities Annual Meeting, Denver, Colorado.
May 23rd 2006. “Lack of Global Access to Care and Therapy: An Ethicist’s View” XXVII International Congress of the World Federation of Hemophilia, Vancouver, Canada.
March 27th 2006. “Equipoise Without the Duty of Personal Care” The Johns Hopkins University School of Public Health.
February 3rd 2006.“Ethical and Methodological Issues in the Transition of Stem Cell Research into Humans: Is There a Conflict Between the ‘Best’ Science and the ‘Best’ Ethics?” Stem Cell Network Workshop on Model Systems & Parkinson’s Disease, Dalhousie University.
December 29th 2005. American Philosophical Association. " Justice in the Belmont Report and the Social Division of Labor."
November 14-15 2005. Panelist "Scientific and Ethical Issues in the Design of Clinical Trials with Usual Care Comparison Arms," sponsored by the National Institutes of Health Clinical Research Policy Analysis and Coordination Program.
October 21st 2005. American Society for Bioethics and Humanities: The Belmont Report: The 25th Anniversary
- Tom Beauchamp, Georgetown University, "The Belmont Report: Some Second Thoughts."
- Ruth Macklin, Albert Einstein College of Medicine, " The Belmont principle of justice: An idea whose time has come."
- Alex John London, Carnegie Mellon University , " Justice in the Belmont Report and the Social Division of Labor."
- Jodi Halpern, Berkeley University, " Rrespect for Persons: How emotions influence the ability to consent to research"
- Franklin G. Miller, National Institutes of Health, " The Ethical Significance of Distinguishing Clinical Research and Medical Care"
Moderator: Rosamond Rhodes, Mount Sinai School of Medicine
August 2nd 2005: “Responsiveness to Host Community Health Needs: Clarifying the Requirement” Johns Hopkins University School of Public Health and Berman Bioethics Institute.
February 18th 2005. "Justice and the Human Development Appraoch to International Research." Georgetown University, Kennedy Institute of Ethics.
October 28, 2004. "Is Wide Reflective Equilibrium a Paper Crown on Bioethics Arguments?" 6th Annual American Society for Bioethics and Humanities Meeting, Philadelphia PA.
Oct. 23-24, 2003. "Discussing Benefits and Burdens" and "Equipoise and Microbicide Trials." International Consultation on Ethical Issues in the Clinical Testing of Microbicides. Washington, DC.
June 25th, 2003: "Going Beyond Reasonable Availability" and "Responsibility of Researchers to the Community" Harvard School of Public Health.
December 10th, 2002: "Sham Surgery Controls in Clinical Trials" Harvard Medical School.
Central APA session on International Research Ethics: Friday, May 4 (9:00-12:00).
Chair: Jeff Kahn, PhD, Director of the Center for Bioethics, University of Minnesota
Speaker: Eric M. Meslin, PhD, Executive Director, National Bioethics Advisory Commission.
Speaker: Alex John London, PhD, Assistant Professor, Carnegie Mellon University
Title: "Equipoise In International Research"
Speaker: Douglas P. Lackey Baruch College, CUNY.
Central APA Group Session: Society for Bioethics and Classical Philosophy: Saturday, May 5 (12:00 - 2:00).
Chair: Alex London (Carnegie Mellon University)
Speaker: Norman O. Dahl (University of Minnesota)
Title: Phronesis in Bioethics
Speaker: Mark Kuczewski (Stritich School of Medicine, Loyola University of Chicago)
Title: Professionalism in Medicine and Character Ethics