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New
Courses
03-450 Cellular and Genetic Mechanisms of Development
Spring: 9 units
Beginning Spring 2006
The development of a single fertilized egg into
a complex multi-cellular organism is an amazing biological phenomenon
that we are only beginning to understand. This course will explore
our current understanding of the cellular and genetic mechanism
that underlie this fundamental process. Focus will be on experimental
approaches taken in model systems (C. elegans, Drosophila, mouse,
etc.) to unravel the mysteries of development. Topics to be covered
will include, but not limited to, aspect of signal transduction
pathway and their consequences, cell cycle regulation, and molecular
control of differential gene expression as they relate to developmental
processes using examples form the primary literature. The course
will be lecture based and include student presentations of current
topics from the literature.
Prerequisites: 03-330 and 03-350
03-744 Membrane Trafficking
Spring: 9 units
While the focus of this course is to analyze
membrane/protein traffic along both the biosynthetic and endocyctic
pathways, our general goal is to teach students how to read and
interpret the literature. In particular, we emphasize the conclusions
and discuss their validity. The course is updated each year to include
topics in which new and interesting developments have occurred.
Emphasis is placed on how membrane traffic is regulated and where
applicable how it is disrupted or subverted during disease processes.
The course is of general interest to students, fellows, and faculty
interested in cell biology, immunology, neurobiology, pharmacology
and virology.
Prerequisites: 03-240 and permission of instructor
03-871 Structural Biophysics
Fall: 12 units
This is an intermediate level course directed at providing a comprehensive
survey of the major biophysical techniques used for characterizing
the structure and dynamics of biological macromolecules. Topics
include optical spectroscopy, fluorescence spectroscopy, Electron
spin resonance, Nuclear magnetic resonance, and X-ray diffraction.
Sufficient theoretical information is provided such that the student
will be able to critically read the current literature. Applications
of these techniques in the current literature are discussed in class.
In addition, an in-depth understanding of the application of the
various techniques to a single biological system is attained by
analysis of a case study at the end of the semester.
Prerequisites: permission of instructor
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