Areas of Research-Department of Biological Sciences - Carnegie Mellon University

Areas of Research in Biochemistry and Biophysics

Structural Biology

  • Structure of normal and mutant human hemoglobins using multinuclear NMR spectroscopy
  • New methods to study membranes using diffuse x-ray and neutron scattering
  • Role of protein dynamics in enzymatic function using NMR methods
  • Computational models, algorithms, and data structures for simulating biological self-assembly processes, such as virus capsid assembly
  • Synthesis of peptide nucleic acids that bind to specific DNA or RNA targets

Cellular Biophysics

  • Mechanical analysis of fibroblast cytoskeletal function

Enzymology

  • Delineation of ribosome assembly pathways using biochemical methods to purify ribosome assembly intermediates
  • Investigation of the biophysical properties of the movement produced by molecular motors, such as kinesin, at the single molecule level

Imaging

  • MRI-based biophysical measurements to elucidate the of development and pathology of the central nervous system
  • Transplantation rejection in model systems using MRI
  • Development of fluorescence-based detection systems for biology and biotechnology