Molecular Biology and Genetics

Peter B. Berget
The Berget laboratory uses molecular biology techniques to engineer single chain antibody fragments to react to specific intracellular signals, thus making them into "biosensors" for networks and pathways.

Charles A. Ettensohn
The Ettensohn laboratory studies gene regulatory networks that underlie embryonic development.

Jonathan Jarvik
In the Jarvik laboratory, viral vectors are used to create mammalian cell lines expressing reporter-tagged proteins that exhibit native regulation while retaining native biochemical and structural integrity.

Adam D. Linstedt
The Linstedt group is investigating molecular mechanisms that establish and maintain the membrane-bounded compartments of the secretory and endocytic pathways. Approaches include permeabilized cell assays, biochemical reconstitutions, cell imaging techniques and molecular genetic experiments.

A. Javier López
The Lopez group employs genetic, genomic, and molecular approaches in Drosophila to characterize regulatory mechanisms for alternative splicing and how they influence development. The role of recursive splicing in the expression and evolution of large transcription units are principal areas of study.

Mark R. Macbeth
The Macbeth lab is interested is interested in RNA-protein interactions, specifically those that involve ADARs, or Adenosine deaminases that act on RNA. We use structural, biochemical and genetic methods to characterize the 3-D ADAR structure, its enzymatic mechanism, and the regulation of its activity.

Brooke M. McCartney
In the field of developmental genetics, the McCartney laboratory uses the powerful genetic tools available in Drosophila to investigate questions of signal transduction and cytoskeletal organization.

Jonathan Minden
Researchers in the Minden laboratory are using genetics and molecular biology approaches to study to role certain genes and proteins play in controlling how cells change shape during Drosophila embryogenesis. They are also using the same methods to study early protein changes during developmentally regulated cell death.

Aaron P. Mitchell
The Mitchell laboratory applies new gene disruption and overexpression strategies to identify C. albicans genes that govern pathogenesis and to understand their functional relationships, and to understand the mechanistic relationships in a fungal endosome-associated signal transduction pathway.

Russell Schwartz
The Schwartz laboratory is developing of mathematical models and computational methods for analyzing genetic polymorphism data, and applying them to problems in disease association study design.

John Woolford
The Woolford group is studying the biogenesis of ribosomes in yeast. After discovering that expression of ribosomal protein genes is coupled with assembly of ribosomes, they have been developing methods for purification and characterization of ribosome assembly intermediates as well as complexes involved in regulating ribosomal protein gene expression.

Eric Xing
Eric Xing developes statistical models and machine learning algorithms for biological network inference and characterization, cis-regulatory module decoding, regulatory evolution modeling, quantitative trait locus mapping, genome polymorphism patterning, and population genetic analysis. He is also applying these quantitative approaches to investigate the mechanisms of breast cancer development and metazoan morphagenesis.