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Genomics, Proteomics, and Systems Biology |
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Ziv Bar-Joseph
Dr. Bar-Joseph's primary research is in computational
and systems biology. Machine learning and statistical algorithms are used
to study time series expression experiments and to combine high throughput
biological data sources to model biological networks.
Peter
B. Berget
The Berget laboratory is collaborating with the Robert Murphy laboratory to develop high throughput techniques to analyze the location and dynamics of GFP tagged proteins in CD-tagged mammalian cell populations.
Justin Crowley
The Crowley laboratory is interested in understanding the cues responsible
for organizing complex patterns of neural circuitry. To this end, the
lab is engaged in an exploration of circuit-specific gene expression patterns
in the developing visual system.
Dannie
Durand
The Durand group works in comparative genomics,
focusing on the evolution of genome organization and functional diversity
in vertebrates.
Charles
Ettensohn
The Ettensohn laboratory is part of a collaboration
that sequenced the genome of the purple sea urchin, Strongylocentrotus
purpuratus. The group is also generating and analyzing extensive EST databases
from this species. The information is being used to study gene regulatory
networks and morphogenetic mechanisms during embryonic development.
Jeffrey O. Hollinger
The Hollinger group investigates molecular and cellular mechanisms in bone regeneration, with particular emphasis on clinical therapies.
Jonathan
Jarvik
The Jarvik laboratory is developing high throughput
methods for trapping genes and observing reporter-tagged gene products
in mammalian cells.
A.
Javier López
The Lopez laboratory is using bioinformatic and
experimental approaches to study mechanisms of expression and evolutionary
dynamics of large introns and also developing methods for global analysis
of splicing intermediates.
Jonathan
Minden
The Minden laboratory is developing new tools
for comparative proteomics. One such method is Difference
Gel Electrophoresis (DIGE), which is sold by Amersham (GE) Biosciences.
Under current development are fluorescent gel imaging hardware and
software. In addition, the Minden group has created a new company, Proteopure, to develop
a universal protein preparation method for proteomics research.
Aaron P. Mitchell
The Mitchell laboratory focuses on gene discovery methods that assign function to the C. albicans genome sequence and identify novel regulatory networks.
Russell
Schwartz
Russell Schwartz has been involved in many projects
involving whole-genome analysis and data mining, and in addition to current
projects in those areas, he is developing computational methods for simulating
biochemistry within the cellular environment.
Nathan
Urban
In the Urban laboratory researchers adopt a systems neuroscience approach
to the study of the main and accessory olfactory systems in rodents. This
work involves the combination of a variety of physiological, computational
and behavioral techniques to answer questions about the representation
and processing of odor-evoked activity linked to the generation of olfactory
behavior.
John
Woolford
The Woolford lab is using state-of-the-art
techniques for epitope tagging genes in the yeast genome and purifying
multimolecular ribosome assembly complexes containing the tagged gene
products. Copurifying proteins are identified by mass spectrometry. Data
for populations of proteins in each pre-ribosome are being analyzed by
computational methods to build models for the assembly of ribosomes in
yeast.
Eric Xing
Eric Xing developes statistical models and machine learning algorithms for biological network inference and characterization, cis-regulatory module decoding, regulatory evolution modeling, quantitative trait locus mapping, genome polymorphism patterning, and population genetic analysis. He is also applying these quantitative approaches to investigate the mechanisms of breast cancer development and metazoan morphagenesis.
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