Jeffrey O. Hollinger
Professor, Biological Sciences and Biomedical Engineering
Director, Bone Tissue Engineering Center
125A Smith Hall
Department of Biological Sciences
Carnegie Mellon University
4400 Fifth Avenue
Pittsburgh, PA 15213
D.D.S., Ph.D., University of Maryland
ResearchThe primary focus for our work is on bone regeneration therapies consisting of biomaterials and soluble signaling molecules. The biomaterials are biodegradable, biocompatible polymers (e.g., polyurethanes, hydrogels) and the signaling molecules include bone morphogenetic protein, platelet derived growth factor and DNA plasmids encoding transcriptional factors runx-2 and osx. The center is using step wise synthesis protocols to control polymer chemical and physical properties as well as grafting bioactive motifs (e.g., 3 to 5 amino acid signals) into the polymer chain backbone to enhance biological activity. Candidate bone therapies are assessed systematically in molecular and cell biology assays and transitioned to pre-clinical animal models such as rats and rabbits. Outcome in animal models is determined by quantitative histomorphometry and biomechanics.
Sasaki A, Mueller R, Gong X, Sipe R, Buck D and Hollinger JO. Mast cells: an unexpected finding in the modulation of cutaneous wound repair by charged beads. Journal of Plastic Reconstructive Surgery, 111(4):1226-1453, 2003.
Zhang JY, Doll BA,Beckman EJ and Hollinger JO. Three-dimensional biocompatible ascorbic acid-containing scaffold for bone tissue engineering. Journal of Tissue Engineering, 9(6):1143-1157, 2003.
Zhang J, Doll BA, Beckman EJ and Hollinger JO. A biodegradable polyurethane-ascorbic acid scaffold for bone tissue engineer. J. Biomed. Mater. Res. 67A(2):389-400, 2003.
Jadlowiec JA, Celil A and Hollinger JO. Bone tissue engineering: recent advances and promising therapeutics agents. Expert Opin. Biol. Ther, 3(3):409-423, 2003.
Hu Y, Winn SR, Krajbich I and Hollinger JO. Pourus polymer scaffolds surface modified with RGD enhance bone cell attachment and differentiation in vitro. J. Biomed. Mat. Res, 64A:583-590, 2003.
Bidic S, Calvert J, Marra K, Kumta P, Campbell P, Mitchell R, Wigginton W, Hollinger JO, Weiss L and Mooney M. Rabbit calvarial wound healing by means of seeded caprotite scaffolds. J. Dent. Res, 82(2): 2003.
Zhang J, Beckman E, Hu J, Yang GG, Agarwal S and Hollinger JO. Synthesis, biodegradability, and biocompatibility of lysine diisocyanate-glucose polymers. J. Tis. Eng, 8(5):771-785, 2002.
Doll BA, Tegtmeier F, Koch H, Acarturk O and Hollinger JO. Evidence of cellular and molecular decline in bone healing with age. Operative Techniques in Orthopaediacs. F.H. Fu, Ed, 12(2):72-77, 2002.
Azari K, Doctor J, Doll B and Hollinger JO. Bone morphogenetic proteins: a review for cranial and maxillofacial surgery. Oral and Maxillo. Surg. Clin. of N.A., 4:1-14, 2002.
Orban J, Marra K and Hollinger JO. Composition options for tissue-engineered bone. Tissue Engineering, 8(4):529-540, 2002.