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03-738 Physical Biochemistry The physical properties of biological macromolecules and the methods used to analyze their structure and function are discussed. Topics covered include: protein architecture, folding and molecular evolution; nucleic acid structure; introduction to structure determination by X-ray crystallography and NMR; biological spectroscopy with emphasis on the biological applications of absorption, fluorescence, NMR, and CD spectroscopies; the kinetics and thermodynamics of protein-ligand interactions; enzyme catalysis; the use of hydrodynamics, chromatography and electrophoresis in the characterization of biological macromolecules; and analysis of biological molecules at the single molecule level. One weekly session will be devoted to the detailed analysis of related research publications. Fall: 12 units |
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